Assessment of sarcopenia using electrical properties of skeletal muscle
| Project/Area Number |
15H05363
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
Yamada Yosuke 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 栄養代謝研究部, 研究員 (60550118)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | サルコペニア / 骨格筋量 / 身体機能 / 筋力 / 生体電気インピーダンス法 / 筋内組成 / 老年学 / スポーツ科学 / 骨格筋 / 老化 / 生体電気インピーダンス / 分光法 / フレイル / 身体活動 / 運動介入 |
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| Outline of Final Research Achievements |
Sarcopenia is defined as age-related loss of skeletal muscle mass and function. Skeletal muscle, in addition to being comprised of a heterogeneous muscle fiber population, also includes extracellular components that do not contribute to positive tensional force production. Here we test segmental bioelectrical impedance spectroscopy (S-BIS) to assess muscle intracellular mass and composition. S-BIS can evaluate electrical properties that may be related to muscle force production. We found that S-BIS measures was more sensitive than traditional methods. Indices of extracellular (noncontractile) and cellular (contractile) compartments in skeletal muscle tissues were determined using the S-BIS measures. Our finding underscores the value of S-BIS to measure muscle composition and suggests that S-BIS should be highly informative in skeletal muscle physiology.
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| Academic Significance and Societal Importance of the Research Achievements |
サルコペニアは、高齢者のフレイルや介護予防の観点から世界的に注目を集めている。現在の国際的な診断基準では、筋量の指標として、二重X線エネルギー吸収法(DXA)や核磁気共鳴画像法(MRI)・X 線CTなどの画像法を推奨している。しかし、これらの装置は、大型で可搬性がなく、多くの介護予防施設等で測定することができない。本研究で用いている部位別生体電気インピーダンス分光(S-BIS)法は、小型・軽量で測定が容易であり、現場で簡便に多数の人の測定が可能である。今回、S-BIS法によるサルコペニア評価ができることが明らかになったことで、健診現場や介護予防教室、ディサービスなどで利用が大いに期待される。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Energy requirement assessment and water turnover in Japanese college wrestlers using the doubly labeled water method.2017
Author(s)
H Sagayama, E Kondo, K Shiose, Yosuke Yamada, K Motonaga, S Ouchi, A Kamei, T Osawa, K Nakajima, H Takahashi, Y Higaki, H Tanaka
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 印刷中
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of 12-wk, short-intermittent, low-intensity, slow-jogging on skeletal muscle, fat infiltration and fitness in older adults: randomized controlled trial.2017
Author(s)
M Ikenaga, Yosuke Yamada, Y Kose, K Morimura, Y Higaki, A Kiyonaga, H Tanaka, Nakagawa Study Group
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Journal Title
European Journal of Applied Physiology
Volume: 117
Issue: 1
Pages: 7-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Timed Up and Go test, atrophy of medial temporal areas and cognitive functions in community-dwelling older adults with normal cognition and mild cognitive impairment2016
Author(s)
Yujiro Kose, Masahiro Ikenaga, Yosuke Yamada, Kazuhiro Morimura, Noriko Takeda, Shinji Ouma, Yoshio Tsuboi, Tatsuo Yamada, Misaka Kimura, Akira Kiyonaga, Yasuki Higaki, Hiroaki Tanaka, for the Nakagawa Study Group
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Journal Title
Experimental Gerontology
Volume: 85
Pages: 81-87
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical application of radial magnetic resonance imaging for evaluation of rotator cuff tear.2015
Author(s)
H Honda, T Morihara, Y Arai, M Horii, H Ito, R Furukawa, Y Kida, T Sukenari, K Ikoma, R Oda, Yosuke Yamada, H Fujiwara, T Kubo
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Journal Title
Orthopaedics & Traumatology: Surgery & Research
Volume: 101
Issue: 6
Pages: 715-719
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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