Identification of "central command" pathways in health and heart failure

• Project/Area Number: 15H05367
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Tottori University
• Principal Investigator: KOBA Satoshi 鳥取大学, 医学部, 准教授 (40565743)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 交感神経 / 光遺伝学 / 運動 / セントラルコマンド / 交感神経活動 / 心不全 / 延髄 / 視床下部 / 中脳 / グルタミン酸 / ラット / 自律神経

Outline of Final Research Achievements

Via in vivo optogenetic experiments and neural tracings combined with immunohistochemistry, we identified central efferent pathways underlying sympathetic adjustments to exercise. A central efferent pathway responsible for excessive sympathoexcitation in heart failure was also found.

Academic Significance and Societal Importance of the Research Achievements

本研究は，CC関連脳部位を「線」で結びつけるという新しい試みから，１９世紀からの学術課題である「運動時交感神経調節の中枢メカニズムの解明」を大きく進めた．また，「脳機能制御」という心疾患に対する未来医療の創出に向けた萌芽となり得る．

Research Products

• [Journal Article] Angiotensin II, oxidative stress, and sympathetic nervous system hyperactivity in heart failure (2018)
  • Author(s): Satoshi Koba
  • Journal Title: Yonago Acta Medica Volume: 印刷中
  • NAID: 130007613079
  • Peer Reviewed
• [Journal Article] Distribution of Fos-immunoreactive cells in the ventral part of rat medulla following voluntary treadmill exercise (2017)
  • Author(s): Kumada Nao、Koba Satoshi、Hanai Eri、Watanabe Tatsuo
  • Journal Title: Auton Neurosci Volume: 208 Pages: 80-87
  • DOI: 10.1016/j.autneu.2017.09.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role played by periaqueductal gray neurons in parasympathetically mediated fear bradycardia in conscious rat (2016)
  • Author(s): Koba, S., Inoue, R. & Watanabe, T.
  • Journal Title: Physiological Reports Volume: 4 Issue: 12 Pages: e12831-e12831
  • DOI: 10.14814/phy2.12831
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Central command: brain control of the circulation during exercise. (2016)
  • Author(s): Satoshi Koba
  • Journal Title: 自律神経 Volume: 53 Pages: 118-121
  • Peer Reviewed
• [Journal Article] Exercise pressor reflex in health and diseases: Animal studies (2015)
  • Author(s): Satoshi Koba
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 4 Issue: 2 Pages: 151-160
  • DOI: 10.7600/jpfsm.4.151
  • NAID: 130005073626
  • ISSN: 2186-8123, 2186-8131
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ホワイトノイズ音曝露によって発現上昇するラット脳内Fosタンパク質の観察 (2015)
  • Author(s): 井上崚、木場智史、渡邊達生
  • Journal Title: 米子医学雑誌 Volume: 66(2/3) Pages: 47-51
  • NAID: 120005614452
  • Peer Reviewed
• [Presentation] Central neural circuitries underlying sympathetic adjustments to exercise (2018)
  • Author(s): Satoshi Koba
  • Organizer: 第95回日本生理学会大会
  • Invited
• [Presentation] Are PVN‐RVLM neurons involved in sympathetic dysfunction in heart failure? (2018)
  • Author(s): Eri Hanai, Satoshi Koba, Nao Kumada, Tatsuo Watanabe
  • Organizer: 第95回日本生理学会大会
• [Presentation] Central neural mechanisms underlying sympathetic hyperactivity in heart failure (2018)
  • Author(s): Satoshi Koba
  • Organizer: 第95回日本生理学会大会
  • Invited
• [Presentation] Blood pressure regulation by neurons projecting from the mesencephalic locomotor region to the rostral ventrolateral medulla in rats (2018)
  • Author(s): Nao Kumada, Satoshi Koba, Eri Hanai, Naoya Kataoka, Kazuhiro Nakamura, Tatsuo Watanabe
  • Organizer: 第95回日本生理学会大会
• [Presentation] 中脳歩行誘発野から延髄吻側腹外側野への投射神経刺激による昇圧反応 (2017)
  • Author(s): 熊田奈桜，木場智史，花井映里，渡邊達生
  • Organizer: 第69回日本生理学会中国四国地方会
• [Presentation] Effect of optogenetic inhibition of PVN-RVLM neurons on sympathetic nerve activity in anesthetized rats with heart failure (2017)
  • Author(s): Eri Hanai, Satoshi Koba, Nao Kumada, Tatsuo Watanabe
  • Organizer: ISAN 2017 - International Society for Autonomic Neuroscience
  • Int'l Joint Research
• [Presentation] Effect of glutamate receptor blockade in RVLM on PVN stimulation-elicited sympathoexcitation in anesthetized rats (2017)
  • Author(s): Satoshi Koba, Eri Hanai, Nao Kumada, Naoya Kataoka, Kazuhiro Nakamura, Tatsuo Watanabe
  • Organizer: ISAN 2017 - International Society for Autonomic Neuroscience
  • Int'l Joint Research
• [Presentation] Optogenetic stimulation of PVN-RVLM neurons increases sympathetic nerve activity in anesthetized rats (2017)
  • Author(s): Satoshi Koba, Eri Hanai, Nao Kumada, Naoya Kataoka, Kazuhiro Nakamura, Tatsuo Watanabe
  • Organizer: Experimental Biology 2017
  • Int'l Joint Research
• [Presentation] 視床下部後部から視床下部室傍核への中枢経路は運動によって活性化する (2017)
  • Author(s): 花井映里、木場智史、渡邊達生
  • Organizer: 第93回日本生理学会大会
• [Presentation] 運動によって活性化するカテコールアミン作動性神経の延髄腹側野における分布 (2017)
  • Author(s): 熊田奈桜、木場智史、渡邊達生
  • Organizer: 第93回日本生理学会大会
• [Presentation] 運動時交感神経活性の中枢経路の探索 (2017)
  • Author(s): 花井映里、熊田奈桜、木場智史、渡邊達生
  • Organizer: 第12回環境生理プレコングレス
• [Presentation] 心不全における運動時交感神経調節の異常と酸化ストレス (2016)
  • Author(s): Satoshi Koba
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2016-03-22
• [Presentation] Caudal lateral/ventrolateral periaqueductal gray projects to the rostral ventrolateral medulla in rats (2016)
  • Author(s): Momone Kato, Satoshi Koba, Ryo Inoue, Tatsuo Watanabe
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2016-03-22
• [Presentation] Does voluntary exercise uniformly increase Fos protein expression within paraventricular hypothalamic nucleus subdivisions in rats? (2016)
  • Author(s): Eri Hanai, Satoshi Koba, Tatsuo Watanabe
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2016-03-22
• [Presentation] 視床下部後部から視床下部室傍核への中枢経路は運動によって活性化する (2016)
  • Author(s): 花井映里、木場智史、渡邊達生
  • Organizer: 第68回日本生理学会中国四国地方会
• [Presentation] 運動トレーニングと循環中枢回路 (2016)
  • Author(s): 木場智史、花井映里、熊田奈桜
  • Organizer: LE2016
  • Invited
• [Presentation] Central efferent projections to medulla for autonomic adjustments to exercise in rats (2016)
  • Author(s): Satoshi Koba, Momone Kato, Eri Hanai, Ryo Inoue, Tatsuo Watanabe
  • Organizer: Experimental Biology 2016
  • Int'l Joint Research
• [Presentation] セントラルコマンド：運動時の循環系の中枢制御 (2015)
  • Author(s): 木場智史
  • Organizer: 第68回日本自律神経学会大会
  • Place of Presentation: ウインクあいち(名古屋市)
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] Central command regulation of sympathetic nerve activity in health and heart failure (2015)
  • Author(s): Satoshi Koba
  • Organizer: The 11th WORLD CONGRESS of the International Society for ADAPTIVE MEDICINE
  • Place of Presentation: 米子コンベンションセンター(米子市)
  • Year and Date: 2015-05-27
  • Int'l Joint Research / Invited