Identification of "central command" pathways in health and heart failure
| Project/Area Number |
15H05367
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Tottori University |
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Principal Investigator |
KOBA Satoshi 鳥取大学, 医学部, 准教授 (40565743)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 交感神経 / 光遺伝学 / 運動 / セントラルコマンド / 交感神経活動 / 心不全 / 延髄 / 視床下部 / 中脳 / グルタミン酸 / ラット / 自律神経 |
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| Outline of Final Research Achievements |
Via in vivo optogenetic experiments and neural tracings combined with immunohistochemistry, we identified central efferent pathways underlying sympathetic adjustments to exercise. A central efferent pathway responsible for excessive sympathoexcitation in heart failure was also found.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は，CC関連脳部位を「線」で結びつけるという新しい試みから，１９世紀からの学術課題である「運動時交感神経調節の中枢メカニズムの解明」を大きく進めた．また，「脳機能制御」という心疾患に対する未来医療の創出に向けた萌芽となり得る．
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Report
(4 results)
Research Products
(25 results)
