The prospective study of development for preventing dementia

• Project/Area Number: 15H05369
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: DOI Takehiko 国立研究開発法人国立長寿医療研究センター, 予防老年学研究部, 室長 (60589026)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000); Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 身体活動 / フレイル / 認知機能 / MCI / 身体機能 / 知的活動 / 加齢・老化 / 高齢者 / 活動 / MRI / 身体活動量

Outline of Final Research Achievements

The purpose of study was to examine factors related to improvement of cognition. This study investigated the relationship, focused on physical and cognitive activity, using magnetic resonance imaging measures with 4 years follow-up. Physical function and physical activity were associated with improvement of cognition. A cross-sectional analysis at baseline revealed these association. Furthermore, continued enhancement of physical activity would contribute to the improvement.

Research Products

• [Int'l Joint Research] Albert Einstein College of Medicine(米国)
• [Int'l Joint Research] Albert Einstein College of Medicine(米国)
• [Journal Article] Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People. (2017)
  • Author(s): Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H.
  • Journal Title: J Am Med Dir Assoc Volume: 18 Issue: 7 Pages: 603-607
  • DOI: 10.1016/j.jamda.2017.02.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Conversion and Reversion Rates in Japanese Older People With Mild Cognitive Impairment (2017)
  • Author(s): Shimada Hiroyuki、Makizako Hyuma、Doi Takehiko、Lee SungChul、Lee Sangyoon
  • Journal Title: Journal of the American Medical Directors Association Volume: 18 Issue: 9 Pages: 808.e1-808.e6
  • DOI: 10.1016/j.jamda.2017.05.017
  • Peer Reviewed
• [Journal Article] Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability. (2017)
  • Author(s): Doi T, Shimada H, Makizako H, Tsutsumimoto K, Verghese J, Suzuki T.
  • Journal Title: J Alzheimers Dis Volume: 59 Issue: 1 Pages: 77-84
  • DOI: 10.3233/jad-170195
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Subjective Memory Complaints are Associated with Incident Dementia in Cognitively Intact Older People, but Not in Those with Cognitive Impairment: A 24-Month Prospective Cohort Study. (2017)
  • Author(s): Tsutsumimoto K, Makizako H, Doi T, Hotta R, Nakakubo S, Makino K, Shimada H, Suzuki T.
  • Journal Title: Am J Geriatr Psychiatry Volume: 25 Issue: 6 Pages: 607-616
  • DOI: 10.1016/j.jagp.2016.12.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gray matter volume and dual-task gait performance in mild cognitive impairment (2016)
  • Author(s): Doi T, Blumen HM, Verghese J, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T.
  • Journal Title: Brain Imaging Behav Volume: 印刷中 Issue: 3 Pages: 887-898
  • DOI: 10.1007/s11682-016-9562-1
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study (2015)
  • Author(s): Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T.
  • Journal Title: J Am Med Dir Assoc Volume: 16 Issue: 12 Pages: 1082-1086
  • DOI: 10.1016/j.jamda.2015.07.007
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Effects of Cognitive Leisure Activity Programs on Cognition in MCI: A Rancomized Controlled Trial (2017)
  • Author(s): Doi T, Verghese J, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T, Shimada H.
  • Organizer: The 21st IAGG World Congress of Gerontology & Geriatrics
  • Int'l Joint Research
• [Presentation] 軽度認知機能障害と歩行速度低下により認知症の発症リスクは増加するか？ (2017)
  • Author(s): 土井剛彦, 牧迫飛雄馬, 堤本広大, 中窪翔, 牧野圭太郎, 堀田亮, 鈴木隆雄, 島田裕之
  • Organizer: 第52回日本理学療法学術大会
• [Presentation] 認知症予防を目指した戦略 (2017)
  • Author(s): 土井剛彦
  • Organizer: 第52回日本理学療法学術大会
  • Invited
• [Presentation] 身体活動と認知症―mild cognitive impairmentに着目して― (2017)
  • Author(s): 土井剛彦, 牧迫飛雄馬, 島田裕之
  • Organizer: 第59回日本老年医学会学術集会
  • Invited
• [Presentation] 地域在住高齢者における身体活動と認知機能～Mild cognitive impairmentに着目して～ (2017)
  • Author(s): 土井剛彦
  • Organizer: 第20回日本運動疫学会学術総会
  • Invited
• [Presentation] Motoric cognitive risk syndrome and risk of Alzheimer’s disease (2016)
  • Author(s): Doi T, Shimada H, Makizako H, Tsutsumimoto K, Verghese J, Suzuki T
  • Organizer: 2016 Alzheimer's Association International Conference
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-07-27
  • Int'l Joint Research
• [Presentation] Motoric Cognitive Risk Syndromeと新規要介護認定発生との関係 (2016)
  • Author(s): 土井剛彦, 島田裕之, 牧迫飛雄馬, 堤本広大, 中窪翔, 堀田亮, 牧野圭太郎, Joe Verghese, 鈴木隆雄.
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2016-06-10