| Budget Amount *help |
¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
We tried to establish a novel synthetic biological systems to control metabolic fates of cells in time scales of seconds to minutes. For the purpose, we applied two independent approaches; (1) controlling the substrate or co-factor concentrations, or (2) controlling the enzymatic functions by small molecule-induced protein oligomerization. Through both approaches, we were able to confirm that the controlling metabolic activity by small molecules will be powerful techniques to understand cellular metabolism or controlling diseases caused by the metabolic malfunctions.
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