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Neural basis for value-based decision making and physiological needs

Research Project

Project/Area Number 15H05374
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Basic / Social brain science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Yamada Hiroshi  筑波大学, 医学医療系, 助教 (70453115)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords脳 / 価値判断 / 線条体 / 神経科学 / 脳・神経 / 動機付け / 意志決定 / 霊長類 / 神経生理学 / 神経経済学 / 神経 / 欲求 / 判断
Outline of Final Research Achievements

The neuronal activity underlying the value-based decision makings depends on the satiety state of animals. I investigated the neural basis for this function during three years: H27-H29. I recorded the neuronal activity from the striatum, which are thought to play crucial roles in this process, and analyzed the data, that brought the following two conclusions.
First, neurons in the ventral striatum showed stronger value modulation with a shorter latency of their responses compared to dorsal striatum one.
Second neurons in the ventral striatum reflect expected values of rewards in contrast to the dorsal striatum neurons, which reflect probability or magnitudes of rewards, individually.I will publish this result soon, while I have seven publications as a part of this research project during the three years.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015 Other

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Free choice shapes normalized value signals in medial orbitofrontal cortex2018

    • Author(s)
      Yamada Hiroshi, Louie Kenway, Tymula Agnieszka, Glimcher Paul W.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 162-162

    • DOI

      10.1038/s41467-017-02614-w

    • NAID

      120007134541

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hunger enhances consistent economic choices in non-human primates2017

    • Author(s)
      Yamada Hiroshi
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 2394-2394

    • DOI

      10.1038/s41598-017-02417-5

    • NAID

      120007134460

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.2017

    • Author(s)
      Yamanaka K, Hori Y, Minamimoto T, Yamada H, Matsumoto N, Enomoto K, Aosaki T, Graybiel AM, Kimura M.
    • Journal Title

      J Neural Transm (Vienna).

      Volume: 21 Issue: 3 Pages: 1-13

    • DOI

      10.1007/s00702-017-1713-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Representation of afferent signals from forearm muscle and cutaneous nerves in the primary somatosensory cortex of the macaque monkey2016

    • Author(s)
      Hiroshi Yamada, Hiroaki Yaguchi, Saeka Tomatsu, Tomohiko Takei, Tomomichi Oya, Kazuhiko Seki
    • Journal Title

      PLOS ONE

      Volume: 11 (10) Issue: 10 Pages: e0163948-e0163948

    • DOI

      10.1371/journal.pone.0163948

    • NAID

      120007129308

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of fast-spiking neurons in the striatum of behaving monkeys.2016

    • Author(s)
      Yamada H, Inokawa H, Hori Y, Pan X, Matsuzaki R, Nakamura K, Samejima K, Shidara M, Kimura M, Sakagami M, Minamimoto T.
    • Journal Title

      Neurosci Res.

      Volume: 105 Pages: 2-18

    • DOI

      10.1016/j.neures.2015.10.003

    • NAID

      120007135484

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of the Lateral Habenula and Anterior Cingulate Cortex in Negative Outcome Monitoring and Behavioral Adjustment in Nonhuman Primates.2015

    • Author(s)
      Kawai, T., Yamada, H., Sato, N., Takada, M., & Matsumoto, M.
    • Journal Title

      Neuron

      Volume: 88 Issue: 4 Pages: 792-804

    • DOI

      10.1016/j.neuron.2015.09.030

    • NAID

      120005997651

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] サル線条体・ドーパミン細胞による特異的な長期的将来報酬表現2017

    • Author(s)
      榎本一紀、山田 洋、松本直幸、 井之川仁、 春野雅彦、木村實
    • Organizer
      第7回社会神経科学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト判断機能の霊長類モデル動物の検討 ~サルの脳を調べる意義とは~2017

    • Author(s)
      山田洋
    • Organizer
      第7回社会神経科学研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経経済学:ヒト判断機能の霊長類モデル動物を用いた研究2017

    • Author(s)
      山田洋
    • Organizer
      第233回つくばブレインサイエンス・セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Context dependent Value Representations in Monkey ventromedial Prefrontal Cortex Neurons2015

    • Author(s)
      Yamada Hiroshi
    • Organizer
      TSUKUBA GLOBAL SCIENCE WEEK
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 筑波大学 研究者総覧

    • URL

      http://trios.tsukuba.ac.jp/researcher/0000003502

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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