Neural basis for value-based decision making and physiological needs

• Project/Area Number: 15H05374
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Basic / Social brain science
• Research Institution: University of Tsukuba
• Principal Investigator: Yamada Hiroshi 筑波大学, 医学医療系, 助教 (70453115)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000); Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000); Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 脳 / 価値判断 / 線条体 / 神経科学 / 脳・神経 / 動機付け / 意志決定 / 霊長類 / 神経生理学 / 神経経済学 / 神経 / 欲求 / 判断

Outline of Final Research Achievements

The neuronal activity underlying the value-based decision makings depends on the satiety state of animals. I investigated the neural basis for this function during three years: H27-H29. I recorded the neuronal activity from the striatum, which are thought to play crucial roles in this process, and analyzed the data, that brought the following two conclusions.
First, neurons in the ventral striatum showed stronger value modulation with a shorter latency of their responses compared to dorsal striatum one.
Second neurons in the ventral striatum reflect expected values of rewards in contrast to the dorsal striatum neurons, which reflect probability or magnitudes of rewards, individually.I will publish this result soon, while I have seven publications as a part of this research project during the three years.

Research Products

• [Journal Article] Free choice shapes normalized value signals in medial orbitofrontal cortex (2018)
  • Author(s): Yamada Hiroshi, Louie Kenway, Tymula Agnieszka, Glimcher Paul W.
  • Journal Title: Nat Commun. Volume: 9 Issue: 1 Pages: 162-162
  • DOI: 10.1038/s41467-017-02614-w
  • NAID: 120007134541
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hunger enhances consistent economic choices in non-human primates (2017)
  • Author(s): Yamada Hiroshi
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 2394-2394
  • DOI: 10.1038/s41598-017-02417-5
  • NAID: 120007134460
  • Peer Reviewed / Open Access
• [Journal Article] Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events. (2017)
  • Author(s): Yamanaka K, Hori Y, Minamimoto T, Yamada H, Matsumoto N, Enomoto K, Aosaki T, Graybiel AM, Kimura M.
  • Journal Title: J Neural Transm (Vienna). Volume: 21 Issue: 3 Pages: 1-13
  • DOI: 10.1007/s00702-017-1713-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Representation of afferent signals from forearm muscle and cutaneous nerves in the primary somatosensory cortex of the macaque monkey (2016)
  • Author(s): Hiroshi Yamada, Hiroaki Yaguchi, Saeka Tomatsu, Tomohiko Takei, Tomomichi Oya, Kazuhiko Seki
  • Journal Title: PLOS ONE Volume: 11 (10) Issue: 10 Pages: e0163948-e0163948
  • DOI: 10.1371/journal.pone.0163948
  • NAID: 120007129308
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristics of fast-spiking neurons in the striatum of behaving monkeys. (2016)
  • Author(s): Yamada H, Inokawa H, Hori Y, Pan X, Matsuzaki R, Nakamura K, Samejima K, Shidara M, Kimura M, Sakagami M, Minamimoto T.
  • Journal Title: Neurosci Res. Volume: 105 Pages: 2-18
  • DOI: 10.1016/j.neures.2015.10.003
  • NAID: 120007135484
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles of the Lateral Habenula and Anterior Cingulate Cortex in Negative Outcome Monitoring and Behavioral Adjustment in Nonhuman Primates. (2015)
  • Author(s): Kawai, T., Yamada, H., Sato, N., Takada, M., & Matsumoto, M.
  • Journal Title: Neuron Volume: 88 Issue: 4 Pages: 792-804
  • DOI: 10.1016/j.neuron.2015.09.030
  • NAID: 120005997651
  • Peer Reviewed / Open Access
• [Presentation] サル線条体・ドーパミン細胞による特異的な長期的将来報酬表現 (2017)
  • Author(s): 榎本一紀、山田 洋、松本直幸、 井之川仁、 春野雅彦、木村實
  • Organizer: 第７回社会神経科学研究会
• [Presentation] ヒト判断機能の霊長類モデル動物の検討 ～サルの脳を調べる意義とは～ (2017)
  • Author(s): 山田洋
  • Organizer: 第７回社会神経科学研究会
  • Invited
• [Presentation] 神経経済学：ヒト判断機能の霊長類モデル動物を用いた研究 (2017)
  • Author(s): 山田洋
  • Organizer: 第233回つくばブレインサイエンス・セミナー
  • Invited
• [Presentation] Context dependent Value Representations in Monkey ventromedial Prefrontal Cortex Neurons (2015)
  • Author(s): Yamada Hiroshi
  • Organizer: TSUKUBA GLOBAL SCIENCE WEEK
  • Place of Presentation: つくば国際会議場（茨城県）
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Remarks] 筑波大学 研究者総覧
  • URL: http://trios.tsukuba.ac.jp/researcher/0000003502