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Development of high-resolution visualization method of single-ion tracks for precision irradiation of nucleus

Research Project

Project/Area Number 15H05432
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Quantum beam science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology (2017-2018)
Kanazawa University (2015-2016)

Principal Investigator

Omichi Masaaki  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 先端機能材料研究部, 主任研究員(定常) (10625453)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2015: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords荷電粒子 / 高分子 / 架橋反応 / 飛跡検出 / 架橋剤 / グラフト重合 / 粒子線 / グラフト重合反応 / 高分子架橋反応 / 電子線 / イオンビーム / 細胞 / クラスターイオン / ナノ構造体
Outline of Final Research Achievements

Prompt determination of spatial points of single-ion tracks plays a key role in high-energy particle induced-cancer therapy and gene/plant mutations. We develop a simple and safe method for the visualization of single ion-track with high resolution by exposing the irradiated polyacrylic acid (PAA) and N, N'-methylene bis acrylamide blend films to water vapor. This method require no etching and could easily distinguish each scar of the charged particle, even in the case of highly dense ion tracks. Furthermore, the scar peaks of different kind ion tracks are separated very easily, even if in the high fluence.

Academic Significance and Societal Importance of the Research Achievements

これまでの粒子線飛跡検出技術はエッチング工程が必要であった。しかし、エッチング工程は強アルカリなどの危険な薬品を使う必要があり、ドラフトなどの特殊な設備が必要であり、照射試験後すぐに測定を行うことが難しかった。本手法では、高分子架橋反応を利用することでエッチング工程に関わる問題がなく、照射試験後すぐに測定を行うことができる。本提案は粒子線の精密照射の最も中核となる飛跡検出技術の開発であり、その成果は医学、生物、化学など多岐にわたるため、その意義は非常に大きい。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (8 results)

All 2019 2018 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Fabrication of Au nanoparticles on poly(vinylpyrrolidone) nanowires exhibiting reversible frequency change of localized surface plasmon resonance2018

    • Author(s)
      S. Tsukuda, S. Seki, M Omichi, M. Sugimoto, A. Idesaki, T. Sekino, T. Omata
    • Journal Title

      AIP Advances

      Volume: 8 Issue: 1 Pages: 015314-015314

    • DOI

      10.1063/1.5001553

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anisotropic swelling of hydrogel nanowires based on poly(vinylpyrrolidone) fabricated by single-particle nanofabrication technique2016

    • Author(s)
      S. Tsukuda, M. Omichi, M. Sugimoto, A. Idesaki, V. S. Padalkar, S. Seki
    • Journal Title

      J. Polym. Sci. Polym. Phys.

      Volume: 54 Issue: 19 Pages: 1950-1956

    • DOI

      10.1002/polb.24100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fabrication of Thermoresponsive Nanoactinia Tentacles by a Single Particle Nanofabrication Technique2015

    • Author(s)
      Masaaki Omichi, Hiromi Marui, Vikas Sudam Padalkar, Akifumi Horio, Satoshi Tsukuda, Masaki Sugimoto, Shu Seki
    • Journal Title

      Langmuir

      Volume: 31 Issue: 42 Pages: 11692-11700

    • DOI

      10.1021/acs.langmuir.5b02962

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Observation of polyethylene lamella layer on radiation grafted materials2018

    • Author(s)
      Natuki Hayashi, Masaaki Omichi, and Seko Noriaki
    • Organizer
      The 12th SPSJ International Polymer Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高分子架橋反応を利用したイオントラックの可視化2016

    • Author(s)
      大道正明、高橋憲司、櫻井庸明、杉本雅樹、関 修平
    • Organizer
      第59回放射線化学討論会
    • Place of Presentation
      国立研究開発法人 量子科学技術研究開発機構 高崎量子応用研究所
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
  • [Book] High-Energy Charged Particles: Their Chemistry and Use as Versatile Tools for Nanofabrication2015

    • Author(s)
      Seki Shu, Sakurai Tsuneaki, Omichi Masaaki, Saeki Akinori, Sakamaki Daisuke
    • Total Pages
      74
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 液体中の気体を脱気する方法、脱気容器及び化合物を反応させる方法2019

    • Inventor(s)
      大道正明、植木悠二、瀬古典明、前川康成
    • Industrial Property Rights Holder
      国立研究開発法人 量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-019684
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 反応溶液、エマルション重合方法、エマルション重合用添加剤及びエマルション重合用の添加剤キット2019

    • Inventor(s)
      大道正明、瀬古典明、前川康成
    • Industrial Property Rights Holder
      国立研究開発法人 量子科学技術研究開発機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-019705
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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