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Symmetry breaking of sequence information and emergence of genetic information in templated ligation system

Research Project

Project/Area Number 15H05460
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Mathematical physics/Fundamental condensed matter physics
Research InstitutionTohoku University

Principal Investigator

Toyabe Shoichi  東北大学, 工学研究科, 准教授 (40453675)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords生命の起源 / 鋳型ライゲーション / 生物物理 / 統計力学 / DNA / パターン形成 / 非平衡
Outline of Final Research Achievements

The emergence of molecular species, which can stably keep and replicate its genetic information, is central to the origin of life. However, the mechanism leading to such emergence remains unknown. Here, on the basis of our previously proposed mechanism for the spontaneous emergence of molecular-species-like structure in templated ligation reaction, we investigated the detailed conditions for this emergence and the interaction between multiple molecular species. In addition, control of information replication error in the templated ligation was achieved.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results)

  • [Presentation] 鋳型ライゲーションにおける一本鎖DNA特異的切断による頻度依存的情報選択2018

    • Author(s)
      畑和樹,間木靖裕,鳥谷部祥一
    • Organizer
      日本物理学会第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DNAの鋳型複製における頻度依存的情報選択の条件検証2018

    • Author(s)
      間木靖裕,鳥谷部祥一
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Symmetry breaking of sequence information in templated ligation, The Origin of Life - Synergy among the RNA, Protein, and Lipid Worlds -2017

    • Author(s)
      S. Toyabe
    • Organizer
      The Origin of Life - Synergy among the RNA, Protein, and Lipid Worlds -
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Emergence of genetic information in information-polymer soup2017

    • Author(s)
      S. Toyabe
    • Organizer
      第55回 日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Experimental demonstration of information retention against diffusional mixing in templated ligation2017

    • Author(s)
      K. Hata, Y. Magi, S. Toyabe
    • Organizer
      第55回 日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Polymerization and information selection in template-directed ligation of information polymers2017

    • Author(s)
      Y. Magi, S. Toyabe
    • Organizer
      第55回 日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Symmetry Breaking of Sequence Information and Emergence of Hypercycles in Information-polymer Soup2016

    • Author(s)
      Shoichi Toyabe
    • Organizer
      Statphys-Taiwan 2016
    • Place of Presentation
      台湾中央研究所(台湾)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sequence Hypercycles by Competitive Ligation2016

    • Author(s)
      Shoichi Toyabe and Dieter Braun
    • Organizer
      Statphys26
    • Place of Presentation
      Lyon (フランス)
    • Year and Date
      2016-07-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emergence of genetic information in information-polymer soup2016

    • Author(s)
      Shoichi Toyabe and Dieter Braun
    • Organizer
      Molecular Origins of Life
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ライゲーションが切り拓く遺伝情報と分子種の起源2016

    • Author(s)
      鳥谷部祥一
    • Organizer
      「冥王代生命学の創成」+「ゆらぎと構造の協奏」合同 研究会
    • Place of Presentation
      田町CIC(東京都・港区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 遺伝情報はいかに生まれうるのか2015

    • Author(s)
      鳥谷部祥一
    • Organizer
      山田研究会
    • Place of Presentation
      ラフォーレ修善寺(静岡県修善寺)
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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