Elucidation of phase behavior of viscous polymer droplet covered with viscous membrane
| Project/Area Number |
15H05463
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
YANAGISAWA Miho 東京農工大学, 工学(系)研究科(研究院), 特任准教授 (50555802)
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| Research Collaborator |
WATANABE Chiho
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 高分子混雑 / 細胞モデル / 分子拡散 / 膜変形 / 粘弾性 / ミクロ閉じ込め / 異常拡散 / 閉じ込め / 膜界面 / 拡散 / 混み合い / 高分子拡散 / ベシクル |
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| Outline of Final Research Achievements |
Non-equilibrium phenomena such as abnormal diffusion have been reported in living cells and cell membrane models. As a factor of the non-equilibrium phenomenon, we assumed that the dense polymer becomes viscoelastic and behaves differently from bulk when confining high concentration polymer solution in the microspace. In this study, we aimed to elucidate the non-equilibrium phenomenon due to the interaction between membrane and polymer by analyzing molecular diffusion and membrane fluctuation using a cell model confining a polymer solution. As a result, a non-equilibrium phenomenon such as (i) abnormal molecule diffusion, (ii) membrane deformation of the cell membrane model due to internal viscosity, for example, was observed when a highly crowded polymer was confined in the microspace.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] DNA cytoskeleton for stabilizing artificial cells2017
Author(s)
Kurokawa Chikako、Fujiwara Kei、Morita Masamune、Kawamata Ibuki、Kawagishi Yui、Sakai Atsushi、Murayama Yoshihiro、Nomura Shin-ichiro M.、Murata Satoshi、Takinoue Masahiro、Yanagisawa Miho
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 114
Issue: 28
Pages: 7228-7233
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Liposome stabilized with cytoskeleton of DNA gel2017
Author(s)
Chikako Kurokawa, Kei Fujiwara, Masamune Morita, Ibuki Kawamata, Yui Kawagishi, Atsushi Sakai, Yoshihiro Murayama, Shin-ichiro M. Nomura, Satoshi Murata, Masahiro Takinoue, Miho Yanagisawa
Organizer
International Symposium on Fluctuation and Structure out of Equilibrium 2017 (SFS2017)
Related Report
Int'l Joint Research
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