| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
In this research, we aimed at the construction of "supramolecular enzyme" by precise arrangement of multiple functional groups including peptides in a crystalline channel of metal-macrocycle framework (MMF) with shape sorting capability. Specifically, we have achieved (1) development of a size-specific heterogeneous catalyst by arranging acid compounds in the channel, (2) control of photoreaction pathways based on the specific spatial effect of MMF, (3) face-selective adsorption of a prochiral compound on the chiral channel surface, and (4) simultaneous arrangement of two different peptides in the channel with the aid of specific anchor residues.
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