Development of procedures to prepare nanogel particles whose pKa value can be reversibly shifted and application of the materials for energy conversion

• Project/Area Number: 15H05486
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Kyushu University
• Principal Investigator: Hoshino Yu 九州大学, 工学研究院, 准教授 (40554689)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000); Fiscal Year 2017: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2016: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: ナノゲル / プロトンインプリント / pKa / 温度応答性 / 温度差電池 / pKa変化 / ナノ粒子 / pKa制御 / 温度応答ゲル / ゲル粒子

Outline of Final Research Achievements

In this project procedures to prepare temperature responsive nanogel particles whose pKa value can be reversibly shifted in response to temperature change has been studied. We found that pKa value of carboxylic acids in the nanogel particles can be tuned by polymerization pH, amount of hydrophobic monomers and cross-linking degree. Thermo-electrochemical cells was developed using nanogel particles as electrolyte. The cells showed Seebeck coefficient of －6.2 mV K－1 by using the combination of proton-coupled electron transfer chemicals and the nanogel particles.

Research Products

• [Int'l Joint Research] University of California, Irvine(米国)
• [Journal Article] Wide-range pKa tuning of proton imprinted nanoparticles for reversible protonation of target molecules via thermal stimuli (2017)
  • Author(s): Hoshino Yu、Miyoshi Takaaki、Nakamoto Masahiko、Miura Yoshiko
  • Journal Title: J. Mater. Chem. B Volume: 5 Issue: 46 Pages: 9204-9210
  • DOI: 10.1039/c7tb02107k
  • Peer Reviewed
• [Journal Article] Design and Preparation of Thermo-Responsive Vinylamine-Containing Microgel Particles for Reversible Absorption of Carbon Dioxide (2017)
  • Author(s): M. Yue, K. Imai, Y. Miura, Y. Hoshino
  • Journal Title: Polymer Journal Volume: 49
  • NAID: 40021272574
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effects of Hydrophobic Modifications and Phase Transitions of Polyvinylamine Hydrogel Films on Reversible CO2 Capture Behavior: Comparison between Copolymer Films and Blend Films for Temperature‐Responsive CO2 Absorption (2017)
  • Author(s): M. Yue, K. Imai, C. Yamashita, Y. Miura, Y. Hoshino
  • Journal Title: Macromol. Chem. and Phys Volume: 218 Issue: 8
  • DOI: 10.1002/macp.201600570
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Design of Synthetic Polymer Nanoparticles that Facilitate Resolubilization and Refolding of Aggregated Positively Charged Lysozyme (2016)
  • Author(s): Masahiko Nakamoto, Tadashi Nonaka, Kenneth J Shea, Yoshiko Miura, Yu Hoshino
  • Journal Title: Journal of the American Chemical Society Volume: 138 Issue: 13 Pages: 4282-4285
  • DOI: 10.1021/jacs.5b12600
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Minimization of Synthetic Polymer Ligands for Specific Recognition and Neutralization of a Toxic Peptide (2015)
  • Author(s): Haejoo Lee, Yu Hoshino, Yusuke Wada, Yuka Arata, Atsushi Maruyama, Yoshiko Miura
  • Journal Title: Journal of the American Chemical Society Volume: 137 Issue: 34 Pages: 10878-10881
  • DOI: 10.1021/jacs.5b05259
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Tuning pKa of Bronsted Acids in Temperature-Responsive Hydrogel Particles by Proton- and Ion-Imprinting Strategy (2018)
  • Author(s): Yu Hoshino
  • Organizer: 255th ACS National Meeting & Exposition
  • Int'l Joint Research / Invited
• [Presentation] Design of Synthetic Polymer Nanoparticles that Function as Molecular Chaperones (2017)
  • Author(s): Yu Hoshino
  • Organizer: Asian International Symposium-Natural Products Chemistry, Chemical Biology/Biofunctional Chemistry and Biotechnology-
  • Place of Presentation: 慶応大学
  • Year and Date: 2017-03-18
  • Int'l Joint Research / Invited
• [Presentation] タンパク質を模倣したナノゲル粒子のpKa制御と機能開発 (2017)
  • Author(s): 星野友
  • Organizer: 日本化学会第97 春季年会特別企画講演生命化学が先導する分子機能創成の最先端：生体機能・生体分子を超えるためのアプローチ
  • Place of Presentation: 慶応大学
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] Tuning pKa Value of Bronsted Acids in Hydrogel Nanoparticles by Ion Imprinting Strategy (2017)
  • Author(s): Yu Hoshino, Toshiki Jibiki, Takaaki Miyoshi, Masaaki Nakamoto Yoshiko Miura
  • Organizer: Gelsympo 2017
  • Place of Presentation: 日大
  • Year and Date: 2017-03-07
  • Int'l Joint Research
• [Presentation] Thermo-Electrochemical Cell Development by Using Temperature Responsive Nanogel (2017)
  • Author(s): Benshuai Guo, Fan Gao, Teppei Yamada, Yoshiko Miura, Yu Hoshino
  • Organizer: The 15th Pacific Polymer Conference
  • Int'l Joint Research
• [Presentation] Improvement of reversible salt absorption efficiency of temperature responsive gel particle composite membrane (2017)
  • Author(s): Mitsunori Moribe, Naoki Gondo, Masahiko Nakamoto, Yu Hoshino and Yoshiko Miura
  • Organizer: 2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers(18th) and Fibers(16th)
  • Int'l Joint Research
• [Presentation] Effect of Composition of Gel Particles on the Immobilization of Carbonic Anhydrase (2017)
  • Author(s): Ryutaro Honda, Tomohiro Gyobu, Hideto Shimahara, Yoshiko Miura, Yu Hoshino
  • Organizer: 2017 Kyushu-Seibu/Pusan-Gyeongnam Joint Symposium on High Polymers(18th) and Fibers(16th)
  • Int'l Joint Research
• [Presentation] タンパク質を模倣したナノゲル粒子の 分子認識機能設計 (2017)
  • Author(s): 星野友
  • Organizer: 第１６２回 東海高分子研究会講演会
  • Invited
• [Presentation] タンパク質の様な動的機能を有する 合成ナノ粒子の設計 (2017)
  • Author(s): 星野友
  • Organizer: 高分子学会関西支部若手会
  • Invited
• [Presentation] タンパク質を模倣した ナノゲルの機能設計 (2017)
  • Author(s): 星野友
  • Organizer: ゲルワークショップ イン 松山
  • Invited
• [Presentation] Thermo-Electrochemical Cell Development by Using Temperature Responsive Nanogel (2017)
  • Author(s): Benshuai Guo, Fan Gao, Teppei Yamada, Yoshiko Miura and Yu Hoshino
  • Organizer: 第66回高分子討論会
• [Presentation] 低温排熱により再生可能な脱塩用ナノゲル膜の塩 収着量の大容量化 (2017)
  • Author(s): 森部 十徳、権藤 直樹、仲本 正彦、星野 友、三浦 佳子
  • Organizer: 第66回高分子討論会
• [Presentation] 炭酸脱水酵素固定化ゲル粒子の開発 (2017)
  • Author(s): 本田 竜 太朗、行部 智洋、島原 秀登、星野 友、三浦 佳子
  • Organizer: 第66回高分子討論会
• [Presentation] 両イオン性ゲル粒子における タンパク質を模倣した可逆的なpKa制御 (2017)
  • Author(s): 地曵 俊紀, 仲本 正彦, 星野 友, 三浦 佳子
  • Organizer: 第66回高分子討論会
• [Presentation] タンパク質の様な動的機能を有する ハイドロゲルナノ粒子の設計 ~汎用性モノマーを用いた分子認識材料の設計~ (2017)
  • Author(s): 星野友
  • Organizer: 高分子同友会
  • Invited
• [Presentation] 温度応答性ゲル粒子からなる可逆脱塩材料の設計 (2017)
  • Author(s): 森部十徳, 権藤直樹, 仲本正彦, 星野友, 三浦佳子
  • Organizer: 第54回化学関連支部合同九州大会
• [Presentation] pKa の異なるゲル粒子を積層させた薄膜のCO2 透過流束の律速段階の検討 (2017)
  • Author(s): 本田竜太朗、行部智洋、渡邉猛、今村和史、山下知恵、谷口育雄、星野友、三浦佳子
  • Organizer: 第54回化学関連支部合同九州大会
• [Presentation] Tuning pKa of Bronsted acids in stimuli responsive nanogel particles by proton- and ion-imprinting strategy for reversible capture of target molecules (2017)
  • Author(s): Yu Hoshino
  • Organizer: Affinity 2017
  • Int'l Joint Research
• [Presentation] 低温排熱の高効率回収を実現する ゲル相転移駆動型の温度差電池の開発 (2017)
  • Author(s): 星野 友、郭本帥、高帆、山田鉄兵、君塚信夫、三浦佳子
  • Organizer: 第66回高分子学会年次大会
• [Presentation] Development of Protein-Mimic Nanoparticles for Effective CO2 Separation (2017)
  • Author(s): Yu Hoshino
  • Organizer: 23rd iCeMS International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Design of Synthetic Polymer Nanoparticles with Dynamic Functions as Enzymes (2016)
  • Author(s): Yu Hoshino, Masahiko Nakamoto, Yoshiko Miura
  • Organizer: The 11th SPSJ International Polymer Conference
  • Place of Presentation: 福岡
  • Year and Date: 2016-12-16
  • Int'l Joint Research
• [Presentation] Active Proton Transport by Liquid Membrane of Temperature-Responsive Nanogel Particles (2016)
  • Author(s): T. Miyoshi, M. Nakamoto, Y. Hoshino, Y. Miura
  • Organizer: The 11th SPSJ International Polymer Conference
  • Place of Presentation: 福岡
  • Year and Date: 2016-12-15
  • Int'l Joint Research
• [Presentation] Development of Hydrogel Films Consisting of Enzyme-Mimic Nano Gel Particles for Energy Efficient CO2 Separation (2016)
  • Author(s): Yu Hoshino
  • Organizer: IWAMSN2016
  • Place of Presentation: ベトナム
  • Year and Date: 2016-11-09
  • Int'l Joint Research / Invited
• [Presentation] アミン含有ゲル粒子フィルムによる二酸化炭素分離技術 (2016)
  • Author(s): 星野友
  • Organizer: 一般財団法人石炭エネルギーセンター「先進的CO2分離回収技術」勉強会
  • Place of Presentation: 一般財団法人石炭エネルギーセンター
  • Year and Date: 2016-10-21
  • Invited
• [Presentation] 省エネルギーのCO2分離の為のナノゲル塗布膜の開発 (2016)
  • Author(s): 星野友
  • Organizer: 第10回中四国若手CE合宿
  • Place of Presentation: 山口
  • Year and Date: 2016-09-28
  • Invited
• [Presentation] タンパク質の様な動的機能を有するハイドロゲルナノ粒子の設計 (2016)
  • Author(s): 星野友
  • Organizer: 第６５回 高分子討論会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2016-09-14
  • Invited
• [Presentation] タンパク質の様な機能を有する材料を汎用性のプラスチック原料から合成できるか？ (2016)
  • Author(s): 星野友
  • Organizer: 東京工業大学生命理工学融合セミナー
  • Place of Presentation: 東工大
  • Year and Date: 2016-08-29
  • Invited
• [Presentation] Development of Nanogel Membranes for CO2 Separation (2016)
  • Author(s): Y. Hoshino, T. Gyobu, K. Imamura, I. Taniguchi, and Y. Miura,
  • Organizer: AMS10
  • Place of Presentation: 奈良
  • Year and Date: 2016-07-27
  • Int'l Joint Research
• [Presentation] Design of Nanogel Particles for Capture and/or Release of Target Molecules/Ions (2016)
  • Author(s): Yu Hoshino
  • Organizer: CIMTEC 2016
  • Place of Presentation: ペルージャ
  • Year and Date: 2016-06-06
  • Int'l Joint Research / Invited
• [Presentation] Protein-mimic strategies to design hydrogel particles that reversibly captures target ions (2015)
  • Author(s): Yu Hoshino, Mengchen Yue, Takaaki Miyoshi, Yoshiko Miura
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honoruru USA
  • Year and Date: 2015-12-12
  • Int'l Joint Research
• [Presentation] Design of Synthetic Polymer Nanoparticles that Recognize Target Biomacromolecules and Ions (2015)
  • Author(s): Yu Hoshino
  • Organizer: 9th International Symposium on Nanomedicine (ISNM) 2015 Mie University
  • Place of Presentation: 三重大学
  • Year and Date: 2015-12-10
  • Int'l Joint Research / Invited
• [Presentation] 高効率な二酸化炭素分離の為のアミン含有ゲル粒子フィルムの大容量化 (2015)
  • Author(s): 星野 友、今村和史、山下知恵、Yue Mengchen、 浜崎央、三浦佳子
  • Organizer: 第４７回化学工学会 秋季大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2015-09-17
• [Presentation] Development of Temperature-Responsive Microgel Films for Reversible CO2 Absorption (2015)
  • Author(s): 星野 友
  • Organizer: I2CNER INTERNATIONAL WORKSHOP on Recent Progress on Membrane Separation and CO2 Capture
  • Place of Presentation: 九州大学
  • Year and Date: 2015-07-16
  • Int'l Joint Research / Invited
• [Presentation] Development of Energy Efficient CO2 Absorbents Consisting of Temperature-responsive Microgel Particles (2015)
  • Author(s): Yu Hoshino
  • Organizer: 98th Canadian Chemistry Conference and Exhibition
  • Place of Presentation: Ottawa, Canada
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Book] Supra-materials Nanoarchitectonics (2016)
  • Author(s): Yuichi Manaka, Takashi Funaki, Takurou N. Murakami, Naohiro Kameta, Yu Hoshino
  • Total Pages: 346
  • Publisher: ELSEVIER
• [Book] タンパク質の様な機能を有する高分子ナノ粒子の設計原理 ～プラスチック抗体・酵素の実現を目指して～ (2016)
  • Author(s): 星野友
  • Total Pages: 6
  • Publisher: 生命化学研究レター
• [Book] タンパク質の脱凝集を促進するプラスチックシャペロン (2016)
  • Author(s): 仲本正彦、三浦佳子、星野 友
  • Total Pages: 2
  • Publisher: Bioscience & Industry
• [Book] CO2可逆吸収材料「アミン含有ゲル粒子」のCO2選択透過膜のへの応用 (2016)
  • Author(s): 星野友、行部智洋、今村和史、谷口育雄、三浦佳子
  • Total Pages: 7
  • Publisher: ケミカルエンジニヤリング
• [Book] 凝集したタンパク質を巻き戻すプラスチックシャペロン (2016)
  • Author(s): 星野友
  • Total Pages: 2
  • Publisher: 化学と工業
• [Book] コンバーテック (2016)
  • Author(s): 山下知恵、三浦佳子、星野友
  • Total Pages: 6
  • Publisher: 株式会社 加工技術研究会
• [Book] ケミカルエンジニヤリング (2015)
  • Author(s): 権藤直樹、仲本正彦、三浦佳子、星野友
  • Total Pages: 5
  • Publisher: 化学工業社
• [Patent(Industrial Property Rights)] 電解液および発電装置 (2017)
  • Inventor(s): 星野友、郭本帥、山田鉄兵、高帆
  • Industrial Property Rights Holder: 九州大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-028444
  • Filing Date: 2017-02-17