| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
The chemical labeling of proteins with synthetic small compound is a key technique in chemical biology, protein-based therapy, and material science. In this study, the novel methodologies were developed based on oxidative tyrosine labeling, which has been inspired by single-electron transfer reaction in biological systems. The tyrosine residue in close proximity to the redox catalyst was labeled with small compounds. These methods were applied to target- and site-selective protein modification.
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