| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Outline of Final Research Achievements |
In the postnatal development of animals,necessary synapses in the brain are strengthened and unnecessary synapses are weakened and eliminated. This process is known as synapse elimination and important for the conversion of immature neural circuit to mature version. In this study, I tried to elucidate roles of neural activity and its molecular basis in synapse elimination of the cerebellar climbing fiber to Purkinje cell synapse in the developing mouse.I found that the neural activity of climbing fiber is necessary to eliminate unnecessary synapses and to complete the innervation of Purkinje cells by necessary climbing fibers. I also found that BDNF promotes synapse elimination and Progranulin counteracts synapse elimination.
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