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In vivo imaging of synaptic plasticity

Research Project

Project/Area Number 15H05571
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionNiigata University

Principal Investigator

Matsui Hideaki  新潟大学, 研究推進機構, 准教授 (60710853)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Keywordsシナプス可塑性 / シナプス / 可視化 / シナプス機能 / 神経科学
Outline of Final Research Achievements

In this study, we aimed to visualize AMPA receptor specifically at the post synaptic membrane and to observe and monitor the plastic and dynamic changes of synaptic functions. In primary neurons, our indicator successfully enables visualization of synaptic functions during chemical LTP or LTD. We have continued to utilize this indicator for hippocampal slice and zebrafish in vivo.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (9 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Invited: 4 results)

  • [Journal Article] An optimized method for counting dopaminergic neurons in zebrafish2017

    • Author(s)
      Matsui Hideaki、Sugie Atsushi
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0184363-e0184363

    • DOI

      10.1371/journal.pone.0184363

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Parkinson’s disease pathogenesis from the viewpoint of small fish models2017

    • Author(s)
      Matsui Hideaki、Takahashi Ryosuke
    • Journal Title

      J Neural Transm

      Volume: 125 Issue: 1 Pages: 25-33

    • DOI

      10.1007/s00702-017-1772-1

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dopamine system, cerebellum, and nucleus ruber in fish and mammals2017

    • Author(s)
      Matsui Hideaki
    • Journal Title

      Dev Growth Differ

      Volume: 59 Issue: 4 Pages: 219-227

    • DOI

      10.1111/dgd.12357

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light.2017

    • Author(s)
      Sugie A, Möhl C, Hakeda-Suzuki S, Matsui H, Suzuki T, Tavosanis G.
    • Journal Title

      Journal of Visual Experiments

      Volume: - Issue: 120

    • DOI

      10.3791/55176

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Use of Fish Models to Study Human Neurological Disorders2017

    • Author(s)
      Hideaki Matsui
    • Journal Title

      Neuroscience Research

      Volume: 16 Pages: 1-7

    • DOI

      10.1016/j.neures.2017.02.004

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 魚のドパミン神経とパーキンソン病2017

    • Author(s)
      Hideaki Matsui
    • Organizer
      第6回生理研霊長研脳研合同シンポジウム
    • Place of Presentation
      新潟大学脳研究所統合脳機能研究センター
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 小型魚類で明らかにする神経病態2016

    • Author(s)
      Hideaki Matsui
    • Organizer
      第46回新潟神経学夏期セミナー
    • Place of Presentation
      新潟大学脳研究所統合脳機能研究センター
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 小型魚類を用いた神経疾患研究2016

    • Author(s)
      Hideaki Matsui
    • Organizer
      第57回神経学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Teleost fish models of Parkinson’s disease.2016

    • Author(s)
      Hideaki Matsui
    • Organizer
      Symposium: Basal Ganglia in Health and Disease (Satellite Symposium of Neuroscience 2016)
    • Place of Presentation
      PACIFICO Yokohama
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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