Circuit mechanisms for the temporal coding in the olfactory bulb
| Project/Area Number |
15H05572
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyushu University (2016-2017)
Institute of Physical and Chemical Research (2015) |
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Principal Investigator |
Imai Takeshi 九州大学, 医学研究院, 教授 (70509851)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2015: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Keywords | 感覚情報処理 / 嗅覚 / 匂い / 時間コーディング / 発火タイミング / 嗅球 / オシレーション / 機械刺激 / 位相コーディング / システム神経生理学 |
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| Outline of Final Research Achievements |
Mitral and tufted (M/T) cells in the olfactory bulb produce rich temporal patterns of activity in response to different odors. However, it remains unknown how they are generated and utilized in olfaction. Here we show that temporal patterning effectively discriminates between the two sensory modalities detected by olfactory sensory neurons (OSNs): odor and airflow-driven mechanical signals. Sniff-induced mechanosensation generates glomerulus-specific oscillatory activity in M/T cells, whose phase was invariant across airflow speed. In contrast, odor stimulation caused phase shifts (phase coding). We also found that odor-evoked phase shifts are concentration invariant and stable across multiple sniff cycles, contrary to the labile nature of rate coding. The loss of oscillatory mechanosensation impaired the precision and stability of phase coding, demonstrating its role in olfaction. Thus, airflow-induced mechanosensation in OSNs is important for phase coding of odor identity.
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Report
(3 results)
Research Products
(11 results)
