Studies on Metastasis of Colon Cancer Using Mouse Models

• Project/Area Number: 15H05574
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: The University of Tokyo
• Principal Investigator: Arimura Sumimasa 東京大学, 医科学研究所, 助教 (60552015)
• Research Collaborator: Yamanashi Yuji 東京大学, 医科学研究所, 教授 (40202387)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000); Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2015: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 腸管腫瘍 / 悪性化 / モデルマウス / 癌 / 浸潤・転移 / 大腸癌

Outline of Final Research Achievements

Most malignant tumor deaths are caused by metastasis with tissue invasion capacity of tumor cells. We previously developed a new mouse model for intestinal malignant tumors. In this study, we demonstrate that tumor progression in these model mice is regulated by tumor microenvironment. Our finding may open new horizons in research of tumor progression and treatment of malignant tumors.

Research Products

• [Journal Article] Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22. (2016)
  • Author(s): Waseda M, Arimura S, Shimura E, Nakae S, and Yamanashi Y
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 478 Issue: 1 Pages: 135-142
  • DOI: 10.1016/j.bbrc.2016.07.079
  • Peer Reviewed
• [Presentation] 神経筋シナプス形成増強治療の創出 (2016)
  • Author(s): 有村純暢
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] DOK7 Gene Therapy Benefits Mouse Models of Diseases Characterized by Defects in the Neuromuscular Junction (2016)
  • Author(s): 有村純暢
  • Organizer: 第34回日本骨代謝学会学術総会/第3回アジア太平洋骨代謝学会議
  • Place of Presentation: 大阪
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] NMJ-enlarging therapy for neuromuscular diseases (2015)
  • Author(s): 有村純暢
  • Organizer: 第21回 日本遺伝子治療学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-24
• [Book] 医学のあゆみ (2015)
  • Author(s): NMJ形成不全を伴う神経筋疾患に対する新規治療概念の創出
  • Total Pages: 2
  • Publisher: 医歯薬出版
• [Book] 実験医学 (2015)
  • Author(s): 神経筋接合部の形成不全を伴う神経筋疾患に対する新規治療概念の創出
  • Total Pages: 4
  • Publisher: 羊土社