Elucidation of the mechanisms for Fbxw7 to suppress cancer metastasis in cancer niches

• Project/Area Number: 15H05575
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Tumor biology
• Research Institution: Kyushu University
• Principal Investigator: Yumimoto Kanae 九州大学, 生体防御医学研究所, 特任助教 (30596838)
• Co-Investigator(Renkei-kenkyūsha): NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000); Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2015: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: がん転移 / がんニッチ / 転移ニッチ / ユビキチン / ユビキチンリガーゼ

Outline of Final Research Achievements

Although the mechanisms of cancer metastasis have been studied as a characteristic of cancer cells, it has become clear that cancer niches surrounding tumor cells have a great influence on metastasis in recent years. A prominent tumor suppressor gene Fbxw7 has also long been analyzed from the viewpoint of cancer suppressor in tumor cells. However, it was found that Fbxw7 is an important factor suppressing cancer metastasis not only in cancer cells but also in bone marrow derived cells constituting a cancer niche.
In addition, we administered propagermanium, a therapeutic agent for hepatitis B, to various cancer metastasis mouse models. We discovered that propagermanium is effective in some cases.

Research Products

• [Journal Article] Fbxw7 suppresses cancer metastasis by inhibiting niche formation. (2015)
  • Author(s): Yumimoto K., Nakayama K. I.
  • Journal Title: Oncoimmunology Volume: 4(8) Issue: 8 Pages: e1022308-e1022308
  • DOI: 10.1080/2162402x.2015.1022308
  • Peer Reviewed
• [Presentation] Keap1の「弱い」ユビキチン化活性は迅速なストレス応答に重要である (2016)
  • Author(s): 弓本佳苗、中山敬一
  • Organizer: BMB2016
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-11-30
• [Presentation] ユビキチンリガーゼFbxw7の新規基質候補MyRF (Myelin Regulatory Factor)の同定と解析 (2016)
  • Author(s): 中山省悟、弓本佳苗、中山敬一
  • Organizer: BMB2016
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-11-30
• [Presentation] 非がん細胞のFbxw7はがんニッチ形成を抑制する (2016)
  • Author(s): 弓本佳苗
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府国際コンベンションセンター
  • Year and Date: 2016-05-31
  • Invited
• [Presentation] 非がん細胞のFbxw7はがんニッチ形成を抑制する (2015)
  • Author(s): 弓本 佳苗、秋吉 清百合、上尾 裕紀、小野山 一郎、上尾 裕昭、大野 真司、森 正樹、三森 功士、中山 敬一
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] ユビキチン化酵素Fbxw7のがんニッチにおける転移抑制メカニズムの解明 (2015)
  • Author(s): 弓本 佳苗
  • Organizer: 平成２７年度がん支援公開シンポジウム
  • Place of Presentation: 一橋講堂 学術総合センター2階
  • Year and Date: 2015-09-09
  • Invited
• [Presentation] Fbxw7 inhibits cancer metastasis in a non-cell-autonomous manner (2015)
  • Author(s): Kanae Yumimoto, Sayuri Akiyoshi, Hiroki Ueo, Yasuaki Sagara, Ichiro Onoyama, Hiroaki Ueo, Masaki Mori, Koshi Mimori, Keiichi I. Nakayama
  • Organizer: The 10th International Symposium of the Institute Network "Towards the next generation research for cancer and Immunology"
  • Place of Presentation: "Frate" Hall, the alumni hall at the Hokkaido University.
  • Year and Date: 2015-07-23
  • Int'l Joint Research / Invited
• [Book] がん抑制因子のがんニッチ細胞における機能 (2016)
  • Author(s): 弓本佳苗, 中山敬一
  • Publisher: メディカルレビュー社
• [Book] 実験医学 (2015)
  • Author(s): ユビキチンリガーゼFbxw7はがんニッチ形成を抑制する
  • Publisher: 羊土社