Understanding Organelle homeostasis through phospholipid transport
| Project/Area Number |
15H05595
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
ENDO Toshiya 京都産業大学, 総合生命科学部, 教授 (70152014)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
|---|
| Keywords | リン脂質 / ミトコンドリア / オルガネラコンタクト / スフィンゴ脂質 / オルガネラコンタクトサイト |
|---|
| Outline of Final Research Achievements |
In this study, we investigated Intracellular logistics systems for lipid transportation. First of all, we succeeded in developing an experimental system to analyze phospholipid transport between the ER and mitochondria in a test tube. Using this system, we identified novel factors involved in the phospholipid and sphingolipid metabolism. Second, we characterized molecular functions of phospholipid transfer proteins in mitochondria. Importantly, we found that organelles, which have been thought to exist separately, directly tether each other and form pathways for transporting phospholipids. These discoveries provide new aspects that could rewrite the concept of cellular structure.
|
Report
(4 results)
Research Products
(50 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution2016
Author(s)
Miwa, K., Kojima, R., Obita, T., Ohkuma, Y., Tamura, Y., and Mizuguchi, M.
-
Journal Title
JOURNAL OF MOLECULAR BIOLOGY
Volume: 428
Issue: 21
Pages: 4258-4266
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
