| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
In this study, we investigated Intracellular logistics systems for lipid transportation. First of all, we succeeded in developing an experimental system to analyze phospholipid transport between the ER and mitochondria in a test tube. Using this system, we identified novel factors involved in the phospholipid and sphingolipid metabolism. Second, we characterized molecular functions of phospholipid transfer proteins in mitochondria. Importantly, we found that organelles, which have been thought to exist separately, directly tether each other and form pathways for transporting phospholipids. These discoveries provide new aspects that could rewrite the concept of cellular structure.
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