| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
The centrosome acts as a microtubule-organizing center at interphase phases; it can mature into a spindle pole during mitosis and transition into a cilium by elongating microtubules from the basal body on cell differentiation or cell cycle arrest. In this study, I identified hierarchical organization of the Subdistal appendages, which play a role for the stability of centrosomal microtubules. I also found that the basal body and primary cilia-related factors regulate various aspects of cell cycle progression. Furthermore, I found that cell cycle regulators, which direct involvement has not been reported so far, may regulate structural transformation of centrosome.
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