| Budget Amount *help |
¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Organogenesis in animals is driven by epithelial morphogenesis in a spatiotemporally controlled manner. To address the cellular mechanisms of epithelial morphogenesis, we analyzed the invagination of tracheal placodes during Drosophila embryogenesis. We found that trh gene that is a master regulator of tracheal cell differentiation is required for maintaining invaginated structures, but is dispensable for driving the invagination movement. Our results suggest that, for maintaining inavaginated structures, trh control the expression of cv-c to downregulate Rho1 small GTPase and Myosin II activity. We propose that the generation of driving forces and stable architecture of epithelial tissues are controlled by genetically separable mechanisms, and epithelial tissues can assume two alternative stable architectures, sheet or tube according to their fate. An appropriate combination of these two control systems is important for robust morphogenesis.
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