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Neuronal communications between circadian clock neurons

Research Project

Project/Area Number 15H05600
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionOkayama University

Principal Investigator

Yoshii Taishi  岡山大学, 自然科学研究科, 准教授 (50611357)

Research Collaborator Charlotte Helfrich-Förster  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords概日時計 / 体内時計 / 時間生物学 / キイロショウジョウバエ / 神経回路
Outline of Final Research Achievements

Many animals possess the central circadian clock system in brain, which controls activity rhythms. However, their detailed neuronal circuits are still not well understood even in the most advanced model animal, fruit fly, Drosophila melanogaster. In this study, we identified circadian clock neurons that are responsive to environmental changes and a new neurotransmitter CCHamide1 involved in the circadian network. Furthermore, we could contribute to understand the morphological and physiological connections among circadian clock neurons.

Academic Significance and Societal Importance of the Research Achievements

概日時計はヒトを含む多くの動物が持つ生物時計機構である。哺乳類などの非常に高度な脳を持つ動物では、概日時計の神経回路の全容を明らかにすることは非常に困難であるが、細胞数が比較的少ないキイロショウジョウバエを用いることで、概日時計を構成する神経回路の形態と機能的役割の一端を明らかにすることができた。哺乳類で報告されている概日時計の神経回路との相似性も見出すことができており、昆虫と哺乳類という進化的に離れている種においても、保存されている神経機構があることが考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (32 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Remarks (3 results)

  • [Int'l Joint Research] 北京大学(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Wurzburg大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Wuerzburg(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Wuerzburg(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Wuerzburg(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila2018

    • Author(s)
      Li MT, Cao LH, Xiao N, Tang M, Deng B, Yang T, Yoshii T, Luo DG
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4247-4247

    • DOI

      10.1038/s41467-018-06506-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster2018

    • Author(s)
      Fujiwara Yuri、Hermann-Luibl Christiane、Katsura Maki、Sekiguchi Manabu、Ida Takanori、Helfrich-F?rster Charlotte、Yoshii Taishi
    • Journal Title

      Frontiers in Physiology

      Volume: 9 Pages: 1-15

    • DOI

      10.3389/fphys.2018.01276

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A tug-of-war between Cryptochrome and the visual system allows the adaptation of evening activity in long summer days in Drosophila melanogaster.2018

    • Author(s)
      Kistenpfennig C, Nakayama M, Nihara R, Tomioka K, Helfrich-Foerster C, Yoshii T
    • Journal Title

      Journal of Biologial Rhythms

      Volume: 33 Issue: 1 Pages: 24-34

    • DOI

      10.1177/0748730417738612

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuroanatomical details of the lateral neurons of Drosophila melanogaster support their functional role in the circadian system2018

    • Author(s)
      Schubert Frank K.、Hagedorn Nicolas、Yoshii Taishi、Helfrich-F?rster Charlotte、Rieger Dirk
    • Journal Title

      The Journal of Comparative Neurology

      Volume: 526 Issue: 7 Pages: 1209-1231

    • DOI

      10.1002/cne.24406

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Circadian temperature adaptations in the fruit fly <i>Drosophila melanogaster</i>2017

    • Author(s)
      UMEZAKI Yujiro、YOSHII Taishi
    • Journal Title

      Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)

      Volume: 34 Issue: 3 Pages: 80-91

    • DOI

      10.3330/hikakuseiriseika.34.80

    • NAID

      130006146314

    • ISSN
      0916-3786, 1881-9346
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neural mechanism of the circadian clock in Drosophila melanogaster2016

    • Author(s)
      吉井大志・富岡憲治
    • Journal Title

      生体の科学

      Volume: 67 Issue: 6 Pages: 532-535

    • DOI

      10.11477/mf.2425200546

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2016-12-15
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Circadian light-input pathways in Drosophila.2016

    • Author(s)
      Yoshii T, Hermann-Luibl C, Helfrich-F&#246;rster C
    • Journal Title

      Communicative & Integrative Biology

      Volume: 9 Issue: 1 Pages: 1-8

    • DOI

      10.1080/19420889.2015.1102805

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Suppressive effects of dRYamides on feeding behavior of the blowfly, Phormia regina2015

    • Author(s)
      Maeda T, Nakamura Y, Shiotani H, Hojo M, Yoshii T, Ida T, Sato T, Yoshida M, Miyazato M, Kojima M, Ozaki M
    • Journal Title

      Zoological Letters

      Volume: 1 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s40851-015-0034-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cryptochrome-dependent and -independent circadian entrainment circuits in Drosophila.2015

    • Author(s)
      Yoshii T, Hermann-Luibl C, Kistenpfennig C, Schmid B, Tomioka K, Helfrich-Foerster C
    • Journal Title

      Journal of Neuroscience

      Volume: 35 Issue: 15 Pages: 6131-6141

    • DOI

      10.1523/jneurosci.0070-15.2015

    • NAID

      120005702488

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] キイロショウジョウバエ概日行動リズムを制御する神経回路2019

    • Author(s)
      吉井大志
    • Organizer
      第63回日本応用動物昆虫学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] キイロショウジョウバエの複眼光受容体と時計細胞を繋ぐ神経回路の探索2018

    • Author(s)
      中山達宏, 吉井大志
    • Organizer
      第70回日本動物学会中国四国支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キイロショウジョウバエにおける新規概日出力因子CCHamide1の概日発現リズム2018

    • Author(s)
      桂万喜,藤原有里,吉井大志
    • Organizer
      第89回日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キイロショウジョウバエ概日時計の光同調に関与する視覚に介在ニューロン2018

    • Author(s)
      中山達宏,吉井大志
    • Organizer
      第89回日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キイロショウジョウバエ時計細胞におけるGAL4発現系統の網羅的探索2018

    • Author(s)
      関口学, 井上浩太郎, 吉井大志
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キイロショウジョウバエの新規概日出力因子CCHamide1はs-LNv 時計細胞からの出力に影響を与える2018

    • Author(s)
      桂万喜, 藤原有里, 吉井大志
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ショウジョウバエ概日時計における時計細胞間カップリング2018

    • Author(s)
      吉井大志
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] キイロショウジョウバエ概日時計における長日適応機構への光受容系の関与2017

    • Author(s)
      丹原瑠璃, 中山真由美, Christa Kistenpfennig, 吉井大志
    • Organizer
      第24回日本時間生物学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キイロショウジョウバエ概日時計の温度同調性2017

    • Author(s)
      吉井大志
    • Organizer
      第24回日本時間生物学会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Light and temperature entrainment of circadian clock in fruit flies2016

    • Author(s)
      Taishi Yoshii
    • Organizer
      The 22nd International Congress of Zoology, The 87th meeting of Zoological Society of Japan
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reciprocal communications of clock neurons via PDF and CCHa1 neuropeptides in Drosophila2016

    • Author(s)
      Taishi Yoshii, Yuri Fujiwara, Christiane Hermann-Luibl, Takanori Ida, Charlotte Helfrich-Foerster
    • Organizer
      SRBR2016
    • Place of Presentation
      Florida, USA
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The CCHa1 neuropeptide as a new candidate for an output factor of the Drosophila circadian clock2015

    • Author(s)
      藤原有里,井田隆徳,吉井大志
    • Organizer
      日本時間生物学会学術大会
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハエの脳の時計2015

    • Author(s)
      吉井大志
    • Organizer
      筑波大学「生命の樹セミナー」
    • Place of Presentation
      茨城県つくば市筑波大学
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] キイロショウジョウバエにおける概日時計の新規出力因子CCHa1神経ペプチドの機能解析2015

    • Author(s)
      藤原有里,井田隆徳,吉井大志
    • Organizer
      日本動物学会
    • Place of Presentation
      新潟市朱鷺メッセ・新潟コンベンションセンター
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Remarks] 研空室のHP

    • URL

      https://sites.google.com/site/chronobiologyokayamauni/

    • Related Report
      2016 Annual Research Report
  • [Remarks] プレスリリース

    • URL

      http://www.okayama-u.ac.jp/tp/release/release_id298.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 時間生物学研究室

    • URL

      https://sites.google.com/site/chronobiologyokayamauni/

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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