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In search for a general tendency of chordate embryonic evolution by analyzing genetic expression patterns during development

Research Project

Project/Area Number 15H05603
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Evolutionary biology
Research InstitutionThe University of Tokyo

Principal Investigator

Irie Naoki  東京大学, 大学院理学系研究科(理学部), 准教授 (10536121)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords進化 / 進化発生学 / 発生 / 反復説 / 進化可能性 / EvoDevo / 発生砂時計モデル / バイオインフォマティクス
Outline of Final Research Achievements

Animals, including human being, have diversified into variety of environments and changed our appearances to a great extent through evolutionary time scale. However, with unknown reasons, basic anatomical features of our body, especially for that in vertebrates (including mammals, reptiles, avian, amphibians, and fish) remained largely unchanged. By studying gene expression profiles during development, we have tackled this problem, as the developmental process is the phase that makes up our body. We have measured and analyzed tens of thousands of genes working during vertebrate embryos, and found out that re-usages of genes may have been constrained the evolutionary diversification of basic anatomical bodyplan of vertebrates.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (21 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 6 results,  Invited: 9 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] CAS-MPG Partner Institute/BGI/Kunming Institute of Zoology(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Taiwan Academia Sinica(Taiwan)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] CAS-MPG Partner Institute/BGI(China)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos2018

    • Author(s)
      Yui Uchida, Masahiro Uesaka, Takayoshi Yamamoto, Hiroyuki Takeda and Naoki Irie
    • Journal Title

      EvoDevo

      Volume: 9:7 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s13227-018-0095-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Centromere evolution and CpG methylation during vertebrate speciation2017

    • Author(s)
      Kazuki Ichikawa, Shingo Tomioka, Yuta Suzuki, Ryohei Nakamura, Koichiro Doi, Jun Yoshimura, Masahiko Kumagai, Yusuke Inoue, Yui Uchida, Naoki Irie, Hiroyuki Takeda* & Shinich Morishita*
    • Journal Title

      Nature Communications

      Volume: 1833 Issue: 1 Pages: 1722-1730

    • DOI

      10.1038/s41467-017-01982-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Constrained vertebrate evolution by pleiotropic genes.2017

    • Author(s)
      Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N; EXPANDE Consortium.
    • Journal Title

      Nat Ecol Evol

      Volume: 1 Issue: 11 Pages: 1722-1730

    • DOI

      10.1038/s41559-017-0318-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Weighted gene co-expression network analysis reveals potential genes involved in early metamorphosis process in sea cucumber Apostichopus japonicus2017

    • Author(s)
      Yongxin Li, Mani Kikuchi, Xueyan Li, Qionghua Gao, Zijun Xiong, Yandong Ren, Ruoping Zhao, Bingyu Mao, Mariko Kondo, Naoki Irie, Wen Wang*
    • Journal Title

      BBRC

      Volume: 495:1 Issue: 1 Pages: 1395-1402

    • DOI

      10.1016/j.bbrc.2017.11.154

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Remaining questions related to the hourglass model in vertebrate evolution.2017

    • Author(s)
      Naoki Irie
    • Journal Title

      Current Opinion in Genetics & Development

      Volume: 45 Pages: 103-107

    • DOI

      10.1016/j.gde.2017.04.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 複雑な遺伝子制御を持つ動物ほど進化可能性が低いかもしれない2018

    • Author(s)
      入江直樹
    • Organizer
      生命の起源および進化学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] In search for a general law of animal embryonic evolution?2017

    • Author(s)
      Naoki Irie
    • Organizer
      The 12th International Workshop on Advanced Genomics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] What are the potential mechanisms that made vertebrates’ bodyplan conserved?2017

    • Author(s)
      Naoki Irie
    • Organizer
      50th Anniversary Meeting of Japanese Society of Developmental Biologists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The developmental hourglass model: the law of embryonic evolution?2017

    • Author(s)
      Naoki Irie
    • Organizer
      From Genetic Networks to a Cellular Wiring Diagram
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] What makes vertebrate embryos to follow the hourglass-like conservation?2016

    • Author(s)
      Naoki Irie
    • Organizer
      Joint meeting of the 22nd International Congress of Zoology and the 87th meeting of Zoologial Society of Japa
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Why are vertebrates’ organogenesis stages evolutionarily conservative?2016

    • Author(s)
      Naoki Irie
    • Organizer
      Hot Spring Harbor Symposium
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Possible constraints on phenotypic evolvability of vertebrates2016

    • Author(s)
      Naoki Irie
    • Organizer
      The 1st B10K meeting
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Potential developmental constraints on vertebrate bodyplan evolution2016

    • Author(s)
      Naoki Irie
    • Organizer
      EuroEvoDevo
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発生システムが動物ボディプラン進化を制約している可能性2015

    • Author(s)
      入江直樹
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸国際会議場・神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大進化スケールにおける発生進化の法則性と定量的検証る可能性2015

    • Author(s)
      入江直樹
    • Organizer
      平成27年度 JSBi生命システム理論研究会
    • Place of Presentation
      東京医科歯科大学・東京
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 動物胚が発生と進化の法則性、砂時計モデルに従うのはなぜか?2015

    • Author(s)
      入江直樹
    • Organizer
      第53回 生物物理学会年会
    • Place of Presentation
      金沢大学・金沢
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 胎児期に刻まれた進化の痕跡2015

    • Author(s)
      入江直樹
    • Total Pages
      152
    • Publisher
      慶應大学出版会
    • Related Report
      2015 Annual Research Report
  • [Remarks] 研究室ウェブサイト

    • URL

      http://www.bs.s.u-tokyo.ac.jp/~hassei/irie/naoki_irie_cv.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-08-25  

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