| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
Food is consisted of both nutrient factors and sensory factors such as taste and smell. Gustatory system plays a critical role in setting a standard to evaluate food quality. By contrast, it is known that this standard is not constant and can change depending on physiological status such as hunger. The mechanism behind this phenomenon, however, remains unclear.
To address this issue, here we manipulate hypothalamic orexigenic neurons to set artificial hunger condition in the mouse brain to analyze the mechanistic insight of hunger-induced taste modification. As a result, the activation of the orexigenic hypothalamic neurons lead to increase in sweet taste sensitivities and to decrease in aversive taste sensitivities, respectively. We revealed that novel role of hypothalamic neurons in taste modulation under hunger.
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