Urinary exosome-derived microRNAs in companion animals:application for kidney injury markers
| Project/Area Number |
15H05634
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Osamu Ichii 北海道大学, 獣医学研究院, 准教授 (60547769)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | 腎臓 / エクソソーム / microRNA / バイオマーカー / Liquid Biopsy / 汎動物学 / 尿 / イヌ・ネコ / イヌ、ネコ / エクソソーム、exosome / 慢性腎臓病、CKD / マイクロRNA、miRNA / 汎動物学、Zoobiquity / イヌ / ネコ / 慢性腎臓病 / マイクロRNA / 獣医学 / 伴侶動物 / 慢性腎臓病（CKD） / マイクロRNA（miRNA） / 尿中エクソソーム |
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| Outline of Final Research Achievements |
The patients with kidney disease are increasing in both companion animals and human. Early diagnosis is a crucial therapeutic strategy for non-regenerative kidney. In this study, we tried to find the biomarker candidates from urinary exosome-derived microRNA to develop the non-invasive “Liquid Biopsy”. In the comprehensive expression analysis and pathological analysis of animals, we identified miR-26a as a candidate for renal glomerular injury marker. Further, several animal species commonly expressed miR-26a in their glomeruli, indicating a possibility of animal species-crossing biomarker. Further, for the application of miRNA to clinical area, we need to clarify further miRNA marker candidates, their correlations with renal function, their dynamics at early disease stage, and their pathological relations with tubulointerstitial lesions.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Urinary exosome-derived microRNAs reflecting the changes of renal function and histopathology in dogs.2017
Author(s)
Ichii O, Ohta H, Horino T, Nakamura T, Hosotani M, Mizoguchi T, Morishita K, Nakamura K, Hoshino Y, Takagi S, Sasaki N, Takiguchi M, Sato R, Oyamada K, Kon Y.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 40340-40340
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes2016
Author(s)
Ichii O, Nakamura T, Irie T, Kouguchi H, Nakamura D, Nakamura S, Sato S, Yokoyama K, Horino T, Sunden Y, Elewa YH, Kon Y
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Journal Title
Histochemistry and Cell Biology
Volume: in press
Issue: 3
Pages: 351-362
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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