| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Outline of Final Research Achievements |
The naked mole rat (NMR) is the longest-living rodent in the world and has extraordinary cancer-resistance. We studied the mechanisms of slow processes of development, growth and senescence in the NMR. We found that temperature and other factors may contribute to slow proliferation of the NMR somatic cells. NMR-iPS cells did not show shortening of G1 phase and acceleration of proliferation compared to the parental skin fibroblasts. We also found a mechanism of NMR-specific metabolic regulation which would contribute to slow proliferation of the NMR somatic cells. Moreover, we also performed functional analysis of the NMR brown adipose tissues.
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