| Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
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| Outline of Final Research Achievements |
To understand the dynamic nature of biological systems at the organ and organism level, we hypothesized that identifying the responsible cells involved in the expression of the phenotype would be crucial. Toward the aim, we applied technologies of "next-generation genetics" and "high-throughput whole-brain imaging (CUBIC)."
We finally reported a demonstration of next-generation mouse genetics (Mol Cell 2017), a rapid three-dimensional observation and analysis pipeline and its applications (Nat Protoc 2015, Neuron 2017 et al.), and next-generation tissue clearing reagent (Cell Rep 2018). We also published review articles related to these two technologies (Cell Chem Biol 2016, npj Syst Biol App 2017).
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