| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2016: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
Calcium signals play crucial roles in maintaining many biological systems including the skeletal and immune system. A number of proteins with EF hand motif that mediate the biological effects of Ca2+ have been identified so far, but the physiological roles of some of them remain largely unknown. The applicant focused on an EF-hand protein Efp and found that hematopoietic cell-specific deficiency of the Efp gene causes severe abnormalities in multiple tissues such as anemia and bone loss. In this study, I tried to elucidate the biological functions of novel Ca2+ signal transducers, Efp and its homologous gene EfpLG, in hematopoietic cell differentiation and bone metabolism mainly by analyzing the genetically deficient mice.
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