Analysis of regulation of the biological systems by novel calcium signal transducers
Project/Area Number |
15H05653
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | The University of Tokyo |
Principal Investigator |
Okamoto Kazuo 東京大学, 大学院医学系研究科(医学部), 特任准教授 (00436643)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2016: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2015: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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Keywords | 造血 / 免疫 / 骨代謝 / 赤血球 |
Outline of Final Research Achievements |
Calcium signals play crucial roles in maintaining many biological systems including the skeletal and immune system. A number of proteins with EF hand motif that mediate the biological effects of Ca2+ have been identified so far, but the physiological roles of some of them remain largely unknown. The applicant focused on an EF-hand protein Efp and found that hematopoietic cell-specific deficiency of the Efp gene causes severe abnormalities in multiple tissues such as anemia and bone loss. In this study, I tried to elucidate the biological functions of novel Ca2+ signal transducers, Efp and its homologous gene EfpLG, in hematopoietic cell differentiation and bone metabolism mainly by analyzing the genetically deficient mice.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] LOX Fails to Substitute for RANKL in Osteoclastogenesis2017
Author(s)
Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H
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Journal Title
Journal of Bone and Mineral Research
Volume: 32
Issue: 3
Pages: 434-439
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Sepsis-induced osteoblast ablation causes immunodeficiency2016
Author(s)
Terashima, A., Okamoto, K., Nakashima, T., Akira, S., Ikuta, K. and Takayanagi, H.
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Journal Title
Immunity
Volume: 44
Issue: 6
Pages: 1434-1443
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immune complexes regulate bone metabolism through FcRγ signalling2015
Author(s)
Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 6637-6637
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 骨免疫と自己免疫疾患2016
Author(s)
岡本一男
Organizer
第34回日本骨代謝学会学術集会
Place of Presentation
大阪国際会議場(大阪府大阪市北区)
Year and Date
2016-07-21
Related Report
Invited
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[Presentation] 適応免疫系による骨の制御2016
Author(s)
岡本一男
Organizer
第2回 日本骨免疫学会
Place of Presentation
ホテルモントレ沖縄(沖縄県国頭群恩納村)
Year and Date
2016-07-07
Related Report
Invited
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[Presentation] Sepsis-induced osteoblast ablation causes immunosuppression2016
Author(s)
Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta and Hiroshi Takayanagi
Organizer
6th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
Place of Presentation
Avra Imperial Hotel(Creta, Greece)
Year and Date
2016-06-21
Related Report
Int'l Joint Research
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[Presentation] 適応免疫系による骨破壊制御2016
Author(s)
岡本一男
Organizer
第60回日本リウマチ学会総会・学術集会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-04-21
Related Report
Invited
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[Presentation] 骨と免疫のクロストーク2016
Author(s)
岡本一男
Organizer
第29回日本創外固定・骨延長学会
Place of Presentation
石川県文教会館(石川県金沢市)
Year and Date
2016-03-19
Related Report
Invited
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[Presentation] 骨と免疫のクロストーク2015
Author(s)
岡本一男
Organizer
第17回福岡小児感染免疫血液カンファレンス
Place of Presentation
ホテル日航福岡(福岡)
Year and Date
2015-07-24
Related Report
Invited
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