| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial joint inflammation and progressive bone destruction. Arthritic bone destruction is considered to be mediated mainly by enhanced activation of osteoclasts at inflammatory sites. To prevent RA-associated bone destruction, it is important to understand the cellular dynamics in inflammatory bone destruction in vivo. In this study, we established an intravital imaging system for visualizing the in vivo behavior of bone-resorbing osteoclasts and their precursors during inflammatory bone destruction. By means of this system, we revealed that various biologics acted at specific therapeutic points during osteoclastic bone destruction, with different efficacies. These results enable us to grasp the real modes of action of drugs, optimizing the usage of drug regimens.
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