Elucidation of the pathogenesis of rheumatoid arthritis and evaluation of drug mechanism and efficacy by intravital imaging techniques
| Project/Area Number |
15H05671
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 生体イメージング / 二光子励起顕微鏡 / 破骨細胞 / 炎症性骨破壊 / 生物学的製剤 / 免疫学 / 関節リウマチ |
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| Outline of Final Research Achievements |
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial joint inflammation and progressive bone destruction. Arthritic bone destruction is considered to be mediated mainly by enhanced activation of osteoclasts at inflammatory sites. To prevent RA-associated bone destruction, it is important to understand the cellular dynamics in inflammatory bone destruction in vivo. In this study, we established an intravital imaging system for visualizing the in vivo behavior of bone-resorbing osteoclasts and their precursors during inflammatory bone destruction. By means of this system, we revealed that various biologics acted at specific therapeutic points during osteoclastic bone destruction, with different efficacies. These results enable us to grasp the real modes of action of drugs, optimizing the usage of drug regimens.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.2016
Author(s)
Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T.
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Journal Title
Sci Rep. 2016 Jan 6;6:18738.
Volume: 6
Issue: 1
Pages: 18738-18738
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 骨免疫イメージング2016
Author(s)
菊田順一
Organizer
第34回日本骨代謝学会学術集会
Place of Presentation
大阪国際会議場
Year and Date
2016-07-21
Related Report
Invited
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