| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Outline of Final Research Achievements |
Proton therapy using scanning method combined with high-concentration cisplatin is considered to be very effective. It is suggested that the pattern of cell death and cell cycle may be different, which partly accounts for the difference in the combined effect. Considering the timing of the increase in G2 arrest, potent biological effects may be obtained by delivering proton irradiation during radiosensitive cell cycle phases in chemo-proton therapy. Proton beam irradiation combined with cisplatin resulted in different phenotype as compared with X rays and cisplatin.
The level of mRNA expressions after irradiation were different between proton and X-ray, especially in genes related to DNA repair. Differences of in vivo biological responses between proton and X-ray beams were found.
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