• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Optimization of human iPS cell derived liver bud transplantation

Research Project

Project/Area Number 15H05677
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

TAKEBE Takanori  横浜市立大学, 先端医科学研究センター, 教授 (20612625)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords再生医学 / 移植外科学 / 移植 / 肝臓原基
Outline of Final Research Achievements

Organoid technology provides a revolutionary paradigm towards therapy, yet to be applied in humans mainly because of the reproducibility and scalability challenges. Here, we overcome these limitations by evolving scalable organ bud production platform entirely from human iPSC. First, we identified effective progenitor populations for generating liver buds in a highly reproducible manner: hepatic endoderm, endothelium and septum mesenchyme. Furthermore, we achieved human scalability by developing an omni-well-array culture platform for mass-producing homogenous and miniaturized liver buds on a large scale (>108-scale). Vascularized and functional liver tissues generated entirely from iPSC significantly improved subsequent hepatic functionalization, enabling functional rescue against acute liver failure via transplantation. Overall, our study provides a stringent manufacture platform for multi-cellular organoid supply, thus facilitating clinical and pharmaceutical applications.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (100 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (74 results) (of which Int'l Joint Research: 28 results,  Invited: 71 results) Book (12 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 3 results)

  • [Journal Article] Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic2018

    • Author(s)
      Yoshinobu Takahashi, Keisuke Sekine, Tatsuya Kin, Takanori Takebe, Hideki Taniguchi
    • Journal Title

      Cell Reports

      Volume: 6 Issue: 6 Pages: 1620-1629

    • DOI

      10.1016/j.celrep.2018.03.123

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells.2017

    • Author(s)
      Takebe T*, Sekine K, Kimura M, Yoshizawa E, Funayama S, Nakanishi N, Hisai T, Kobayashi T, Mori A, Ayano S, Ejiri Y, Amimoto N, Yamazaki Y, Ogawa S, Ishikawa M, Kiyota Y, Ueno Y, Taniguchi H
    • Journal Title

      Cell Reports

      Volume: 21 Issue: 10 Pages: 2661-2670

    • DOI

      10.1016/j.celrep.2017.11.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multilineage communication regulates human liver bud self-organization from pluripotency.2017

    • Author(s)
      Camp JG, Sekine K, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R, Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T*, Treutlein B
    • Journal Title

      Nature

      Volume: 546 Issue: 7659 Pages: 533-534

    • DOI

      10.1038/nature22796

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Liver Regeneration Using Cultured Liver Bud2017

    • Author(s)
      Sekine K, Takebe T, Taniguchi H.
    • Journal Title

      Methods Mol Biol

      Volume: 1597 Pages: 207-216

    • DOI

      10.1007/978-1-4939-6949-4_15

    • ISBN
      9781493969470, 9781493969494
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic engineering: Organoids meet organs-on-a-chip2017

    • Author(s)
      Takebe T*, Zhang B, Milica R
    • Journal Title

      Cell Stem Cell

      Volume: 21(3) Issue: 3 Pages: 297-300

    • DOI

      10.1016/j.stem.2017.08.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism.2017

    • Author(s)
      Koike H, Zhang RR, Ueno Y, Sekine K, Zheng YW, Takebe T, Taniguchi H.
    • Journal Title

      Development

      Volume: 144(6) Pages: 1018-1024

    • DOI

      10.1242/dev.143032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multilineage communication regulates human liver bud self-organization from pluripotency.2017

    • Author(s)
      Camp JG, Sekine K, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R, Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T, Treutlein B
    • Journal Title

      Nature

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.2017

    • Author(s)
      Asai A, Aihara E, Mizuochi T, Phelan K, Mayhew C, Shivakumar P, Takebe T, Wells J, Bezerra J
    • Journal Title

      Development

      Volume: 144(6) Pages: 1056-1064

    • DOI

      10.1242/dev.142794

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autotransplantation of monkey ear perichondrium-derived progenitor cells for cartilage reconstruction.2016

    • Author(s)
      Kagimoto S, Takebe T*, Kobayashi S, Yabuki Y, Hori A, Hirotomi K, Mikami T, Uemura T, Maegawa J, Taniguchi H
    • Journal Title

      Cell transplantation

      Volume: 25(5) Issue: 5 Pages: 951-962

    • DOI

      10.3727/096368916x690917

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation2015

    • Author(s)
      T. Takebe, M. Eomura, E. Yoshizawa, M. Kimura, H. Koike, Y. Ueno, T. Matsuzaki, T. Yamazaki, T. Toyohara, K. Osafune, H. Nakauchi, H. Y. Yoshikawa, H. Taniguchi
    • Journal Title

      Cell Stem Cell

      Volume: 16 Issue: 5 Pages: 556-565

    • DOI

      10.1016/j.stem.2015.03.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒトオルガノイドを用いたホロミクス研究の可能性2018

    • Author(s)
      武部貴則
    • Organizer
      多次元生命システム研究戦略分子・細胞アトラスに関する意見交換会 JST研究開発戦略センター(CRDS)ライフサイエンス・臨床医学ユニット
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 研究の未来を考えよう2018

    • Author(s)
      武部貴則
    • Organizer
      再生医療学会総会市民公開講座
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 再生医学x広告医学-0から1への挑戦2018

    • Author(s)
      武部貴則
    • Organizer
      01 Doctor Initiative
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト肝炎オルガノイドを用いたホロミクス研究2018

    • Author(s)
      武部貴則
    • Organizer
      再生医療学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 次世代オルガノイド研究の展望 The era of Organoid Medicine2018

    • Author(s)
      武部貴則
    • Organizer
      再生医療学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト器官原基法に基づく移植医療応用への試み2018

    • Author(s)
      武部貴則
    • Organizer
      再生医療学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 臓器再生への挑戦!2018

    • Author(s)
      武部貴則
    • Organizer
      第3回Koishikawa Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 次世代オルガノイド研究の展望 The era of Organoid Medicine2018

    • Author(s)
      武部貴則
    • Organizer
      農芸化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The era of Organoid Medicine - Liver Organoid Based Approach2018

    • Author(s)
      Takebe Takanori
    • Organizer
      Southern California Stem Cell Seminar Series
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 次世代オルガノイド研究と創生医学-The era of Organoid Medicine-2018

    • Author(s)
      武部貴則
    • Organizer
      理研 CDB-大塚製薬連携センター 第 2 回合同セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 歩きたくなる階段ツアー2018

    • Author(s)
      武部貴則
    • Organizer
      横浜市立大学教員向け Staff Development研修
    • Related Report
      2017 Annual Research Report
  • [Presentation] The era of Organoid Medicine4.02018

    • Author(s)
      Takebe Takanori
    • Organizer
      Regenerative Biology and Stem Cell Seminar Series Northwestern University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 2 Lives - Future of Healthcare2017

    • Author(s)
      武部貴則
    • Organizer
      第2回 01 Doctor Initiative
    • Place of Presentation
      The Place of Tokyo(東京都港区)
    • Year and Date
      2017-05-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒト臓器創出への挑戦2017

    • Author(s)
      武部貴則
    • Organizer
      久留米大学講演
    • Place of Presentation
      久留米大学(福岡県久留米市)
    • Year and Date
      2017-05-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ミニ臓器技術を核とした産業形成への展望2017

    • Author(s)
      武部貴則
    • Organizer
      CPhI / ICSE / P-MEC / BioPh / InnoPack Japan 2017
    • Place of Presentation
      東京ビックサイト(東京都江東区)
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Human Organ Bud Generation From Stem Cell Towards Therapy2017

    • Author(s)
      Takebe T
    • Organizer
      Liver Seminar Series, Albert Eistein Colledge of Medicine
    • Place of Presentation
      NYC, USA
    • Year and Date
      2017-04-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞が創る新しい社会2017

    • Author(s)
      武部貴則
    • Organizer
      「医学を志す」講演会
    • Place of Presentation
      聖光学院(神奈川県横浜市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 器官創出技術を用いた医療応用への展望2017

    • Author(s)
      武部貴則
    • Organizer
      愛媛大講演
    • Place of Presentation
      愛媛大学(愛媛県松山市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] De novo generation of diverse organ buds from stem cells2017

    • Author(s)
      Takebe T
    • Organizer
      KEYSTONE SYMPOSIA ON Molecular and Cellular Biology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] De novo generation of diverse organ buds from stem cells.2017

    • Author(s)
      Takebe T
    • Organizer
      Endocrinology Seminar Cincinnati
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2017-02-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミニ臓器創出技術を核とする戦略的iPS細胞研究2017

    • Author(s)
      武部貴則
    • Organizer
      平成28年度先導技術交流会シンポジウム
    • Place of Presentation
      東京国立研究開発法人産業技術総合研究所臨海副都心センター(東京都江東区)
    • Year and Date
      2017-02-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ミニ臓器創出と臨床応用2017

    • Author(s)
      武部貴則
    • Organizer
      新化学技術推進協会(JACI)講演会
    • Place of Presentation
      新化学技術推進協会(東京都千代田区)
    • Year and Date
      2017-01-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 臓器創出への展望20202017

    • Author(s)
      武部貴則
    • Organizer
      小野薬品工業株式会社
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オルガノイド技術を用いたヒト肝臓発生の理解と制御2017

    • Author(s)
      武部貴則
    • Organizer
      第40回日本分子生物学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 臓器創出への挑戦2017

    • Author(s)
      武部貴則
    • Organizer
      弘前大学 先端医療に携わる人材育成事業セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 臓器創出への展望2017

    • Author(s)
      武部貴則
    • Organizer
      東京医科歯科大学 平成29年度第1回 統合研究機構先端研究セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Growing organ bud towards therapy2017

    • Author(s)
      武部貴則
    • Organizer
      New York Stem Cell Foundation Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Growing organ bud towards therapy2017

    • Author(s)
      Takebe Takanori
    • Organizer
      The 27th Hot Spring Harbor International Symposium, Frontiers in Stem Cell Research and Reprogramming
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organoid biology and regenerative medicine2017

    • Author(s)
      Takebe Takanori
    • Organizer
      1st Joint Meeting on Health and Medical Care between Thailand and Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 臓器再生への展望2017

    • Author(s)
      武部貴則
    • Organizer
      日興コーディアル証券株式会社
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Organ Bud Based Approach Towards Therapy2017

    • Author(s)
      武部貴則
    • Organizer
      理研CLST Educationalセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Future of Heathcare20202017

    • Author(s)
      武部貴則
    • Organizer
      大成建設株式会社
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] iPS細胞由来ミニ肝臓を用いた再生医療2017

    • Author(s)
      武部貴則
    • Organizer
      第38回日本炎症・再生医学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] iPS細胞由来ミニ肝臓と血漿蛋白産生2017

    • Author(s)
      武部貴則
    • Organizer
      第65回日本輸血・細胞治療学会講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Human Liver Bud Transplantation Towards Therapy2017

    • Author(s)
      Takebe Takanori
    • Organizer
      ISSCR 2017 ANNUAL MEETING
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human Organoid Based Approach Towards Therapy2017

    • Author(s)
      Takebe Takanori
    • Organizer
      Boston Takeda RMU day
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 2 Lives - Future of Healthcare-2017

    • Author(s)
      武部貴則
    • Organizer
      第2回 01 Doctor Initiative
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト臓器創出への挑戦2017

    • Author(s)
      武部貴則
    • Organizer
      久留米大学
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミニ臓器技術を核とした産業形成への展望2017

    • Author(s)
      武部貴則
    • Organizer
      CPhI / ICSE / P-MEC / BioPh / InnoPack国際医薬中間体展
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒト器官原基法に基づく移植医療応用への試み2017

    • Author(s)
      武部貴則
    • Organizer
      第19回外科分子細胞治療研究会
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] Human Organ Bud Generation From Stem Cell Towards Therapy2017

    • Author(s)
      Takebe Takanori
    • Organizer
      Albert Eistein College of Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Radial Prototyping-ヒト臓器創出へ向けて-2016

    • Author(s)
      武部貴則
    • Organizer
      大日本住友製薬講演
    • Place of Presentation
      大日本住友製薬株式会社大阪研究所(大阪府大阪市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Modeling human organ development2016

    • Author(s)
      武部貴則
    • Organizer
      2016 年 東西合同スクリフス会講演
    • Place of Presentation
      TKP東京駅八重洲カンファレンスセンター(東京都中央区)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 臓器形成におけるヘテロジェネイティの理解と制御2016

    • Author(s)
      武部貴則
    • Organizer
      日本分子生物学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Regenerative Medicine Frontline - Tissues and organs2016

    • Author(s)
      Takebe T
    • Organizer
      2016 World Alliance Forum
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞由来ミニ臓器移植によるヒト臓器の創出2016

    • Author(s)
      武部貴則
    • Organizer
      都医学研セミナー
    • Place of Presentation
      東京都医学総合研究所(東京都世田谷区)
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Engineering Liver Via iPSC2016

    • Author(s)
      Takebe T
    • Organizer
      2016 Basic Research Workshop American Association for Study of Liver Disease Annual meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] De novo generation of diverse organ buds from stem cells.2016

    • Author(s)
      Takebe T
    • Organizer
      EMBL Conference for Organoids: Modelling Organ Development and Disease in 3D Culture
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generating organ buds towards therapy2016

    • Author(s)
      takebe T
    • Organizer
      From Stem Cells to Human Development Company of Biologists
    • Place of Presentation
      Southbridge, MA, USA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 器官原基移植によるヒト臓器創出への挑戦2016

    • Author(s)
      武部貴則
    • Organizer
      小児消化器栄養肝臓学会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ミニ臓器と臨床応用2016

    • Author(s)
      武部貴則
    • Organizer
      JASIS 2016 サイエンスイノベーションゾーン
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 多細胞系からなる複雑なヒト臓器の人為的創出2016

    • Author(s)
      武部貴則
    • Organizer
      化学とマイクロ・ナノシステム学会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 次世代のヘルスケア基盤創出2016

    • Author(s)
      武部貴則
    • Organizer
      大塚製薬薬局薬店特別講演
    • Place of Presentation
      大塚製薬株式会社徳島研究所(徳島県徳島市)
    • Year and Date
      2016-07-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 次世代のヘルスケア産業基盤創出2016

    • Author(s)
      Takebe T
    • Organizer
      Word Alliance Forum executive club
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-06-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] De novo generation of diverse organ buds towards therapy2016

    • Author(s)
      Takebe T
    • Organizer
      De novo generation of diverse organ buds towards therapy
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトiPS細胞由来器官原基移植療法の開発2016

    • Author(s)
      武部貴則
    • Organizer
      日本炎症・再生医学会シンポジウム4
    • Place of Presentation
      京都みやこめっせ(京都府京都市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 器官原基移植によるヒト臓器創出への展望2016

    • Author(s)
      武部貴則
    • Organizer
      信濃町循環器セミナー
    • Place of Presentation
      慶應義塾大学(東京都新宿区)
    • Year and Date
      2016-06-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS細胞由来器官原基移植療法の開発2016

    • Author(s)
      武部貴則
    • Organizer
      第61回日本透析医学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-06-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 多細胞系からなる複雑なヒト臓器の人為的構成2016

    • Author(s)
      武部貴則
    • Organizer
      先端医療振興財団 H28神戸再生医療勉強会
    • Place of Presentation
      神戸臨床研究情報センター(兵庫県神戸市)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いたヒト代謝性臓器の創出2016

    • Author(s)
      武部貴則
    • Organizer
      第63回日本実験動物学会総会
    • Place of Presentation
      ミューザ川崎シンフォニーホール(神奈川県川崎市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 臓器創出への展望2016

    • Author(s)
      武部貴則
    • Organizer
      大塚製薬講演
    • Place of Presentation
      大塚ホールディングス株式会社(東京都港区)
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] iPS細胞由来器官原基移植によるヒト臓器の創出2016

    • Author(s)
      武部貴則
    • Organizer
      第64回日本輸血・細胞治療学会総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 器官創出技術を用いた医療応用への展望2016

    • Author(s)
      武部貴則
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Generation of Diverse Organ Buds from Human iPSCs.2016

    • Author(s)
      Takebe T
    • Organizer
      French Society for Cell and Gene Therapy
    • Place of Presentation
      Marseille, France
    • Year and Date
      2016-03-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血管構造を有する 複雑なヒト臓器の人為的構成2015

    • Author(s)
      武部貴則
    • Organizer
      分生・生化学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generating diverse organ buds from stem cells.2015

    • Author(s)
      Takebe T
    • Organizer
      JST CREST-PRESTO joint international symposium
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human iPSC-derived organ bud based approaches.2015

    • Author(s)
      Takebe T
    • Organizer
      112th ITC(INTERNATIONAL TITISEE CONFERENCE
    • Place of Presentation
      Mainz, Germany
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro reconstructions and controls of multicellular structures.2015

    • Author(s)
      Takebe T
    • Organizer
      The 26th CDB Meeting Mechanistic Perspectives of Multicellular Organization
    • Place of Presentation
      理化学研究所 多細胞システム形成研究センター(兵庫県神戸市)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] De novo generation of liver buds from stem cells.2015

    • Author(s)
      Takebe T
    • Organizer
      International Conference of Future Hepatology at Kaohsiung
    • Place of Presentation
      Kaohsiung, Taiwan
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] De novo generation of diverse organ buds from iPSCs towards therapy.2015

    • Author(s)
      Takebe T
    • Organizer
      ISSCR 2015 ANNUAL MEETING
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Realization of human iPSC-derived liver bud transplantation therapy.2015

    • Author(s)
      Takebe T
    • Organizer
      the Young Investigators’ Stem Cell Symposium 2015
    • Place of Presentation
      Biopolis, Singapore
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 臨床応用の基盤形成を目指した肝再生研究の新展開2015

    • Author(s)
      武部貴則
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regenerative approaches through developmental biology.2015

    • Author(s)
      Takebe T
    • Organizer
      EASL, 50th the International Liver Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-04-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human iPSC-derived organ bud based approaches towards clinical application.2015

    • Author(s)
      Takebe T
    • Organizer
      8th Pan Pacific Symposium 2015 on Stem Cells and Cancer Research
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 『挑む!化学を拓く28人』再生医療研究のホープiPS細胞から臓器を作る2017

    • Author(s)
      武部貴則、他著
    • Total Pages
      247
    • Publisher
      日本経済新聞出版社
    • ISBN
      9784532520731
    • Related Report
      2017 Annual Research Report
  • [Book] オルガノイド4.0時代 次世代のオルガノイド研究のデザイン2017

    • Author(s)
      武部貴則
    • Total Pages
      139
    • Publisher
      実験医学
    • ISBN
      9784758125000
    • Related Report
      2017 Annual Research Report
  • [Book] 小児内科 Vol.492017

    • Author(s)
      武部貴則
    • Total Pages
      100
    • Publisher
      東京医学社
    • Related Report
      2017 Annual Research Report
  • [Book] Reverse Engineering Organ Buds through Self-Driven Condensation and Organization.2017

    • Author(s)
      Shinozawa T, Yoshikawa H-Y, Takebe T
    • Total Pages
      8
    • Publisher
      Developmental Biology
    • Related Report
      2017 Annual Research Report
  • [Book] Rational design of mechanical environment for self-organizing organ bud2017

    • Author(s)
      松崎賢寿,吉川洋史,谷口英樹,武部貴則
    • Total Pages
      3
    • Publisher
      日本バイオマテリアル学会誌
    • Related Report
      2017 Annual Research Report
  • [Book] Impact of mechanical environment on cell adhesion regulating biological process2017

    • Author(s)
      松崎賢寿,吉川洋史,谷口英樹,武部貴則
    • Total Pages
      5
    • Publisher
      化学とマイクロ・ナノシステム学会誌
    • Related Report
      2017 Annual Research Report
  • [Book] Engineering pancreatic tissues from stem cells towards therapy.2016

    • Author(s)
      Takahashi Y, Takebe T, Taniguchi H
    • Total Pages
      9
    • Publisher
      Regenerative Therapy
    • Related Report
      2015 Annual Research Report
  • [Book] iPS由来器官原基移植による機能的なヒト肝臓の創出2015

    • Author(s)
      谷口英樹、武部貴則
    • Total Pages
      18
    • Publisher
      最新医学
    • Related Report
      2015 Annual Research Report
  • [Book] 肝胆膵2015

    • Author(s)
      谷口英樹、武部貴則
    • Total Pages
      8
    • Publisher
      アークメディア
    • Related Report
      2015 Annual Research Report
  • [Book] 月刊 糖尿病 DIABETES2015

    • Author(s)
      谷口英樹、武部貴則
    • Total Pages
      7
    • Publisher
      医学出版
    • Related Report
      2015 Annual Research Report
  • [Book] 膵島の再生医療-膵β細胞の発生と再生をめぐる新展開-2015

    • Author(s)
      谷口英樹、武部貴則
    • Total Pages
      5
    • Publisher
      診断と治療
    • Related Report
      2015 Annual Research Report
  • [Book] Annual Review 2015 糖尿病・代謝・内分泌2015

    • Author(s)
      武部貴則、谷口英樹
    • Total Pages
      6
    • Publisher
      中外医学
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] digitalized human organoids and methods of using same.2017

    • Inventor(s)
      1Takebe T, Kimura M
    • Industrial Property Rights Holder
      1Takebe T, Kimura M
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞選別法2017

    • Inventor(s)
      松﨑賢寿,谷口英樹,武部貴則
    • Industrial Property Rights Holder
      松﨑賢寿,谷口英樹,武部貴則
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-043744
    • Filing Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 培養方法及び細胞塊2015

    • Inventor(s)
      谷口英樹、武部貴則、江尻洋子
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞培養システム2015

    • Inventor(s)
      谷口英樹、武部貴則、関根圭輔、砂山裕信、西村哲也、中尾敦
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Overseas

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi