| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
The liver has robust regenerative potential in response to damage, but hepatic steatosis weakens this potential. That is known the impaired liver regeneration causes complications after surgery, such as liver failure. However the detail of mechanisms was unclear. The enhanced integrated stress response (ISR) is commonly induced by various cellular stress. We found that ISR plays a key role in impaired regeneration of hepatic steatosis. In this study, we revealed that stress induced transcription factor has an important role as the mechanism of liver regeneration disorder in fatty liver disease.
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