| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
Through comprehensive analysis of gene expression in ligament samples from ossification of the posterior longitudinal ligament (OPLL) patients, we identified that Cyclin dependent kinase 1 (Cdk1) was involved in the initiation and progression of OPLL. The role of Cdks in this process have not been extensively studied. In this study, we demonstrated that Cdk1 regulates skeletal development based on chondrocyte-specific loss-of-function experiments performed in a mouse model. Cdk1 functions as a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Furthermore, using an osteoblast-specific loss-of-function mouse model, we demonstrated that Cdk1 regulates osteoblast proliferation and differentiation.
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