Analysis by a new imaging system for three-dimensional detection of nanoscale vibrations in the inner ear
| Project/Area Number |
15H05683
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Niigata University |
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Principal Investigator |
Nin Fumiaki 新潟大学, 医歯学系, 准教授 (80644905)
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| Research Collaborator |
日比野 浩 新潟大学, 医学部 分子生理学, 教授
崔 森悦 新潟大学, 工学部 電気電子工学科, 助教
Lecture Tobias Reichenbach インペリアルカレッジ
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Keywords | ナノ微小振動 / 蝸牛 / 感覚上皮帯 / 内耳 / ナノ振動計測 / 進行波 / トモグラフィ / 有毛細胞 / 基底板振動 / OCT |
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| Outline of Final Research Achievements |
We have developed an imaging system that can detect the object’s nano-scale vibrations. In addition, we succeeded to record a baseline shift of the vibration by a newly derived laser interferometer. Based on the recorded data, we hypothesized that the vibrations depend on the hair cells’ function, and performed mathematical simulation of the sensory epithelia. Lastly, we confirmed the hypothesis by the experiments in which we used animals and applied some drugs in vivo. These results not only show the new mechanism for the vibration of the sensory epithelia, but also found that the mechanism are related to the hari cells’ function for the first time.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice.2017
Author(s)
Watabe T, Xu M, Watanabe J, Higuchi T, Hori K, Sato MP, Nin F, Hibino H, Ogawa K, Masuda M, Tanaka KF.
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Journal Title
Sci Rep
Volume: 00
Pages: 13605-13605
Related Report
Peer Reviewed
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[Journal Article] The unique ion permeability profile of cochlear fibrocytes and its contribution to establishing their positive resting membrane potential,2016
Author(s)
T. Yoshida, F. Nin, S. Murakami, G. Ogata, S. Urtsuka, S. Choi, T. Nakagawa, H. inohara, S. Komune, Y. Kurachi, H. Hibino
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Journal Title
Pflugers Arch.
Volume: 468
Issue: 9
Pages: 1609-1619
DOI
Related Report
Peer Reviewed
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[Journal Article] The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance.2016
Author(s)
Nin F, Yoshida T, Sawamura S, Ogata G, Ota T, Higuchi T, Murakami S, Doi K, Kurachi Y, Hibino H.
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Journal Title
Pflugers Arch
Volume: 468
Issue: 10
Pages: 1637-1649
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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