Therapeutic strategy targeting extracellular histones in sepsis-associated DIC
Project/Area Number |
15H05684
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Emergency medicine
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Research Institution | Kagoshima University |
Principal Investigator |
ITO Takashi 鹿児島大学, 医歯学総合研究科, 講師 (20381171)
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Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA IKURO 鹿児島大学, 大学院医歯学総合研究科, 特任教授 (20082282)
NAKAHARA MAYUMI 鹿児島大学, 医歯学域医学系, 助教 (90707514)
KAWAHARA KO-ICHI 大阪工業大学, 工学部生命工学科, 特任教授 (10381170)
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Research Collaborator |
NAGASATO TOMOKA 藤森工業株式会社
YAMADA SHINGO 株式会社シノテスト
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
Keywords | 敗血症 / 播種性血管内凝固症候群 / 細胞外ヒストン / トロンボモジュリン / コンドロイチン硫酸 / 集中治療 / DAMPs / DAMPs |
Outline of Final Research Achievements |
Recombinant thrombomodulin (rTM) inhibited histone-induced platelet aggregation and neutrophil extracellular trap (NET) formation in vitro. rTM also inhibited histone-induced NET formation in kidneys, and attenuated histone-induced renal dysfunction in rats. rTM with a chondroitin sulfate side chain (rTM type II) had higher affinity for histone H3 and H4 than the traditional rTM (Type I), and thus, inhibited histone-induced platelet aggregation and NET formation more efficiently than rTM type I. These findings suggest that rTM type II can be a promising therapeutic option for sepsis-associated disseminated intravascular coagulation. Further studies are needed to elucidate in vivo effects of rTM type II in septic conditions.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.2017
Author(s)
Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K,Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I.
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Journal Title
Oxid Med Cell Longev.
Volume: Article ID 6873281
Pages: 14-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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