| Project/Area Number |
15H05688
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
FUKUMOTO Satoshi 東北大学, 歯学研究科, 教授 (30264253)
MIYAZAKI Kanako 九州大学, 大学病院, 助教 (30778840)
ARAI Chieko 九州大学, 大学病院, 研究員 (60802288)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 歯 / 歯原性上皮細胞 / 細胞分化 / 細胞運命決定 / 歯の再生 / 再生医学 / 分化 |
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| Outline of Final Research Achievements |
Epithelial-mesenchymal interaction plays critical roles for the development of organs such as tooth, lung, salivary gland, kidney and hair. During this process, epithelial thickening and budding into mesenchyme are common phenomenon, while the decision of cell fate is made by the specific transcriptional controls of individual organs. In this study, we analyzed the mechanisms of cell fate conversion using mouse model, which generates ectopic hair in tooth. This mouse model also showed enamel hypoplasia in tooth, indicating that the capability of dental cell fate transition into hair cells.
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