| Budget Amount *help |
¥162,240,000 (Direct Cost: ¥124,800,000、Indirect Cost: ¥37,440,000)
Fiscal Year 2019: ¥32,240,000 (Direct Cost: ¥24,800,000、Indirect Cost: ¥7,440,000)
Fiscal Year 2018: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2017: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2016: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Fiscal Year 2015: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
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| Outline of Final Research Achievements |
In this study, we aimed to develop a new technology that can control the function and fate of cells by utilizing the RNP system, which consists of RNA-protein complexes. As a result, we succeeded in achieving all three of research goals: 1) Development of RNA switch technology and RNA-based synthetic circuits that identify and control the fate of mammalian cells. 2) Design and construction of RNA nanostructures that can control the spatial arrangement of target proteins, and 3) Creation of an artificial RNP system that functions in cells. We believe that the originality and novelty of the research on the control of cell fate based on RNP molecular design is high, and new genetic manipulation and cell control technologies based on RNP systems have been established. Further development of RNA and RNP technologies in academic and medical applications is expected in the future.
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