| Budget Amount *help |
¥200,850,000 (Direct Cost: ¥154,500,000、Indirect Cost: ¥46,350,000)
Fiscal Year 2019: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2018: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2017: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2015: ¥104,910,000 (Direct Cost: ¥80,700,000、Indirect Cost: ¥24,210,000)
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| Outline of Final Research Achievements |
Up until now, gene-encoded imaging probes were created using known protein fragments that bind to the molecule of interest to be detected. In this study, we applied molecular evolution engineering to develop a technology to create a new imaging probe using a peptide aptamer library or a small molecule antibody with a completely new sequence. In connection with this, we have developed technology for visualizing biological phenomena and evolutionary engineering technology such as immuno-PCR method. The developed technology is useful for elucidation of biological phenomena and medical treatment.
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