Budget Amount *help |
¥182,520,000 (Direct Cost: ¥140,400,000、Indirect Cost: ¥42,120,000)
Fiscal Year 2019: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2018: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2017: ¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000)
Fiscal Year 2016: ¥33,800,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥7,800,000)
Fiscal Year 2015: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
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Outline of Final Research Achievements |
Through theory, evolutionary simulation, and experiments on the adaptation and evolution of E. coli, we uncovered and formulated universal laws of fluctuation and response of cells, and constructed a quantitative theory of the state of life. Specifically, we clarified the relationship between cell growth fluctuation and proliferation, the law between proliferation and death, the low-dimensional constraint of phenotype as a result of robustness, and the proportionality in the change of phenotype due to adaptation and evolution, together with prediction on resistance of bacteria to antibiotics. Also, the central dogma of molecular biology on separation of function and information is derived from spontaneous symmetry breaking.
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