Advanced Trace Organic Compound Study in Planetary Materials: Development of High Sensitivity and High Resolution

• Project/Area Number: 15H05749
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Geochemistry/Cosmochemistry
• Research Institution: Kyushu University
• Principal Investigator: Naraoka Hiroshi 九州大学, 理学研究院, 教授 (20198386)
• Co-Investigator(Kenkyū-buntansha): 濱瀬 健司 九州大学, 薬学研究院, 教授 (10284522)
• Project Period (FY): 2015-05-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥201,240,000 (Direct Cost: ¥154,800,000、Indirect Cost: ¥46,440,000); Fiscal Year 2019: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000); Fiscal Year 2018: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2017: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2016: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000); Fiscal Year 2015: ¥98,540,000 (Direct Cost: ¥75,800,000、Indirect Cost: ¥22,740,000)
• Keywords: 地球外物質 / 惑星微量有機化合物 / 炭素質隕石 / 超高質量分解能 / 高分離クロマトグラフィー / 分子イメージング / サンプルリターン / 化学進化 / 地球外有機化合物 / 高感度分析 / その場分析 / 有機分子イメージング / 質量分析 / 高感度 / 高分解能 / 超高分解能質量分析 / 高分離 / 空間分布 / 多次元クロマトグラフィー / 化合物イメージング / 高分解能分析 / 超高分解質量分析 / アミノ酸 / 隕石 / 超高分解能 / クロマトグラフィー / クリーンルーム / 微量惑星有機化合物

Outline of Final Research Achievements

Advanced instrumental development and analyses are performed in order to study the trace organic compounds of extraterrestrial materials: (1) a clean room environment to avoid organic contamination during analysis; (2) highmass‐resolution analysis coupled with high-performance liquid chromatography (HPLC) to determine the elemental composition using exact mass for inferring the chemical structure; (3) nano-liquid chromatography (nanoLC) to enhance the sensitivity; (4) superior chromatographic separation using a multi‐dimensional system to determine the optical isomers of amino acids; and (5) in situ organic compound analysis and molecular imaging of the sample surface. This approach revealed a higher complexity of organic compounds with a heterogeneous distribution in meteorites. The developed methods can be applied to study the chemical evolution of meteoritic organic compounds as well as molecular occurrence in low‐mass extraterrestrial materials such as asteroid-returned samples.

Academic Significance and Societal Importance of the Research Achievements

宇宙・太陽惑星系には遍く有機分子が存在して、生命誕生への関与も示唆されているが、地球外有機物は非常に複雑で、その存在状態・生成メカニズムは解明されていない。本研究の学術的意義は地球外有機物の化学進化の一端を理解できたことであり、宇宙での普遍的な有機分子の進化を洞察できたことである。また、日米で実施中の炭素質小惑星からのサンプルリターン計画でもたらされる試料の分析体制が整ったことである。開発した分析法は宇宙・地球化学のみにとらわれず、医療・食品などの分野にも使用され、人間生活への貢献という社会的意義もある。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Determination of Chiral Amino Acids in Various Fermented Products Using a Two-Dimensional HPLC-MS/MS System (2019)
  • Author(s): ISHII Chiharu、AKITA Takeyuki、NAGANO Masanobu、MITA Masashi、HAMASE Kenji
  • Journal Title: CHROMATOGRAPHY Volume: 40 Issue: 2 Pages: 83-87
  • DOI: 10.15583/jpchrom.2019.011
  • NAID: 130007676147
  • ISSN: 1342-8284, 1348-3315
  • Year and Date: 2019-06-20
  • Peer Reviewed / Open Access
• [Journal Article] Development of a Three-Dimensional HPLC System for the Simultaneous Determination of Lactate and 3-Hydroxybutyrate Enantiomers in Mammalian Urine (2019)
  • Author(s): Chin-Ling HSIEH, Po-Yeh LIN, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE
  • Journal Title: CHROMATOGRAPHY Volume: 40 Issue: 1 Pages: 25-32
  • DOI: 10.15583/jpchrom.2018.021
  • NAID: 130007612989
  • ISSN: 1342-8284, 1348-3315
  • Year and Date: 2019-02-20
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct distribution of soluble N-heterocyclic compounds between CM and CR chondrites (2019)
  • Author(s): Naraoka Hiroshi、Hashiguchi Minako
  • Journal Title: GEOCHEMICAL JOURNAL Volume: 53 Issue: 1 Pages: 33-40
  • DOI: 10.2343/geochemj.2.0546
  • NAID: 130007594529
  • ISSN: 0016-7002, 1880-5973
  • Peer Reviewed / Open Access
• [Journal Article] High‐mass resolution molecular imaging of organic compounds on the surface of Murchison meteorite (2019)
  • Author(s): Hashiguchi Minako、Naraoka Hiroshi
  • Journal Title: Meteoritics & Planetary Science Volume: 54 Issue: 2 Pages: 452-468
  • DOI: 10.1111/maps.13211
  • Peer Reviewed
• [Journal Article] Simultaneous total analysis of core and polar membrane lipids in archaea by high‐performance liquid chromatography/high‐resolution mass spectrometry coupled with heated electrospray ionization (2019)
  • Author(s): Horai Shunsuke、Yamauchi Noriaki、Naraoka Hiroshi
  • Journal Title: Rapid Communications in Mass Spectrometry Volume: 33 Issue: 20 Pages: 1571-1577
  • DOI: 10.1002/rcm.8506
  • Peer Reviewed
• [Journal Article] Nucleobase synthesis in interstellar ices (2019)
  • Author(s): Y. Oba, Y. Takano, H. Naraoka, N. Watanabe and A. Kouchi
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 4413-4413
  • DOI: 10.1038/s41467-019-12404-1
  • Peer Reviewed / Open Access
• [Journal Article] New Applications of High-Resolution Analytical Methods to Study Trace Organic Compounds in Extraterrestrial Materials (2019)
  • Author(s): Naraoka、Hashiguchi、Sato、Hamase
  • Journal Title: Life Volume: 9 Issue: 3 Pages: 62-62
  • DOI: 10.3390/life9030062
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional high-performance liquid chromatographic determination of Asn, Ser, Ala, and Pro enantiomers in the plasma of patients with chronic kidney disease (2019)
  • Author(s): Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE
  • Journal Title: Analytical Chemistry Volume: 91 Issue: 18 Pages: 11569-11575
  • DOI: 10.1021/acs.analchem.9b01615
  • Peer Reviewed
• [Journal Article] Bulk chemical characteristics of soluble polar organic molecules formed through condensation of formaldehyde: Comparison with soluble organic molecules in Murchison meteorite (2019)
  • Author(s): Yuki Isono, Shogo Tachibana, Hiroshi Naraoka, Francois-Regis Orthous-Daunay, Laurette Piani, Yoko Kebukawa
  • Journal Title: GEOCHEMICAL JOURNAL Volume: 53 Issue: 1 Pages: 41-51
  • DOI: 10.2343/geochemj.2.0551
  • NAID: 130007592011
  • ISSN: 0016-7002, 1880-5973
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ultraviolet-photon fingerprints on chondritic large organic molecules (2019)
  • Author(s): Orthous‐Daunay F.‐R., Piani L., Flandinet L., Thissen R., Wolters C., Vuitton V., Poch O., Moynier F., Sugawara I., Naraoka H. and Tachibana S.
  • Journal Title: GEOCHEMICAL JOURNAL Volume: 53 Issue: 1 Pages: 21-32
  • DOI: 10.2343/geochemj.2.0544
  • NAID: 130007591565
  • ISSN: 0016-7002, 1880-5973
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Further characterization of carbonaceous materials in Hayabusa-returned samples to understand their origin (2019)
  • Author(s): Uesugi Masayuki、Ito Motoo、Yabuta Hikaru、Naraoka Hiroshi、Kitajima Fumio、Takano Yoshinori、Mita Hajime、Kebukawa Yoko、Nakato Aiko、Karouji Yuzuru
  • Journal Title: Meteoritics & Planetary Science Volume: 54 Issue: 3 Pages: 638-666
  • DOI: 10.1111/maps.13236
  • NAID: 120006630615
  • Peer Reviewed
• [Journal Article] Multi-Dimensional HPLC Analysis of Serine Containing Chiral Dipeptides in Japanese Traditional Amber Rice Vinegar (2018)
  • Author(s): SEREEKITTIKUL Nutchaya、KOGA Reiko、AKITA Takeyuki、FURUSHO Aogu、REISCHL Roland、MITA Masashi、FUJII Akira、HASHIGUCHI Kazunori、NAGANO Masanobu、LINDNER Wolfgang、HAMASE Kenji
  • Journal Title: CHROMATOGRAPHY Volume: 39 Issue: 2 Pages: 59-66
  • DOI: 10.15583/jpchrom.2018.002
  • NAID: 130007403307
  • ISSN: 1342-8284, 1348-3315
  • Year and Date: 2018-06-20
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a Highly-Sensitive Two-Dimensional HPLC System with Narrowbore Reversed-Phase and Microbore Enantioselective Columns and Application to the Chiral Amino Acid Analysis of the Mammalian Brain (2018)
  • Author(s): FURUSHO Aogu、KOGA Reiko、AKITA Takeyuki、MIYOSHI Yurika、MITA Masashi、HAMASE Kenji
  • Journal Title: CHROMATOGRAPHY Volume: 39 Issue: 2 Pages: 83-90
  • DOI: 10.15583/jpchrom.2018.007
  • NAID: 130007403273
  • ISSN: 1342-8284, 1348-3315
  • Year and Date: 2018-06-20
  • Peer Reviewed / Open Access
• [Journal Article] In situ organic compound analysis on a meteorite surface by desorption electrospray ionization coupled with an Orbitrap mass spectrometer (2018)
  • Author(s): Naraoka Hiroshi、Hashiguchi Minako
  • Journal Title: Rapid Communications in Mass Spectrometry Volume: 32 Issue: 12 Pages: 959-964
  • DOI: 10.1002/rcm.8121
  • Peer Reviewed
• [Journal Article] Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid (2018)
  • Author(s): Ishii Chiharu、Akita Takeyuki、Mita Masashi、Ide Tomomi、Hamase Kenji
  • Journal Title: Journal of Chromatography A Volume: 1570 Pages: 91-98
  • DOI: 10.1016/j.chroma.2018.07.076
  • Peer Reviewed
• [Journal Article] Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrow-bore online two-dimensional high-performance liquid chromatography system (2018)
  • Author(s): C.-L. Hsieh, R. Koga, A. Furusho, T. Akita, M. Mita, T. Ide, J.-A. Lee, K. Hamase
  • Journal Title: Journal of Separation Science Volume: 41 Issue: 6 Pages: 1-9
  • DOI: 10.1002/jssc.201701283
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular evolution of N-containing cyclic compounds in the parent body of the Murchison meteorite. (2017)
  • Author(s): Naraoka, H, Yamashita, Y, Yamaguchi, M. and Orthous-Daunay F. R.
  • Journal Title: ACS Earth Space Chem. Volume: 1 Issue: 9 Pages: 540-550
  • DOI: 10.1021/acsearthspacechem.7b00058
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A new family of extraterrestrial amino acids in the Murchison meteorite. (2017)
  • Author(s): Koga, T. and Naraoka, H.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 636-636
  • DOI: 10.1038/s41598-017-00693-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deuterium Fractionation upon the Formation of Hexamethylenetetramines through Photochemical Reactions of Interstellar Ice Analogs Containing Deuterated Methanol Isotopologues (2017)
  • Author(s): Y. Oba, Y. Takano, H. Naraoka, A. Kouchi, N. Watanabe
  • Journal Title: The Astrophysical Journal Volume: 849 Issue: 2 Pages: 122-122
  • DOI: 10.3847/1538-4357/aa8ea5
  • Peer Reviewed / Open Access
• [Journal Article] Formation of diastereoisomeric piperazine-2,5-dione from DL-alanine in the presence of olivine and water. (2017)
  • Author(s): Fuchida, S., Naraoka, H. and Masuda, H.
  • Journal Title: Origin Life Evol. Biosphe Volume: 47 Issue: 1 Pages: 83-92
  • DOI: 10.1007/s11084-016-9500-7
  • Peer Reviewed
• [Journal Article] Two-dimensional HPLC-MS/MS determination of multiple D-amino acid residues in the proteins stored under various pH conditions (2017)
  • Author(s): C. Ishii, T. Miyamoto, S. Ishigo, Y. Miyoshi, M. Mita, H. Homma, T. Ueda, K. Hamase
  • Journal Title: Chromatography Volume: 38 Pages: 65-72
  • NAID: 130007040478
  • Peer Reviewed
• [Journal Article] Formation of diastereoisomeric piperazine-2,5-dione from DL-alanine in the presence of olivine and water (2016)
  • Author(s): Fuchida, S., Naraoka, H. and Masuda, H.
  • Journal Title: Origins of Life and Evolution of Biospheres Volume: in press
  • Peer Reviewed
• [Journal Article] ToF-SIMS analysis of carbonaceous particles in the sample catcher of the Hayabusa spacecraft. (2015)
  • Author(s): Naraoka, H., Aoki, D., Fukushima, K., Uesugi, M., Ito, M., Kitajima, F., Mita, H., Yabuta, H., Takano, Y., Yada, T., Ishibashi, Y., Karouji, Y., Okada, T. and Abe, M.
  • Journal Title: Earth, Planets and Space Volume: 67 Issue: 1 Pages: 67-67
  • DOI: 10.1186/s40623-015-0224-0
  • NAID: 120006800831
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] エポックメイキングな隕石たち その６：Murchison隕石～地球外有機化合物の証拠～ (2015)
  • Author(s): 奈良岡浩
  • Journal Title: 日本惑星科学会誌「遊星人」 Volume: 24 Pages: 277-281
  • NAID: 110010000415
  • Open Access
• [Presentation] Initial analysis plan of soluble organic compounds for the Hayabusa2 sample from asteroid Ryugu (2019)
  • Author(s): H. Naraoka, Y. Takano, J. P. Dworkin and SOM analysis team
  • Organizer: 日本地球惑星連合大会2019
• [Presentation] Soluble organic matter (SOM) analysis plan of the Hayabusa2-returned samples (2019)
  • Author(s): H. Naraoka, Y. Takano, J. P. Dworkin and SOM analysis team
  • Organizer: The 82nd Annual Meeting of the Meteoritical Society
  • Int'l Joint Research
• [Presentation] 有機化合物反応時におけるカンラン石の効果 (2019)
  • Author(s): 宮﨑惇也、奈良岡浩
  • Organizer: 第37回有機地球化学シンポジウム
• [Presentation] 始原隕石中の炭素クラスターの存在について (2019)
  • Author(s): 奈良岡浩
  • Organizer: 2019年度日本地球化学会第66回年会
• [Presentation] Organosulfur compounds in carbonaceous chondrites: Implications for organic reaction pathways in the meteorite parent bodies (2019)
  • Author(s): H. Naraoka
  • Organizer: The 42nd Antarctic Meteorite Symposium
• [Presentation] Enantioselective multi-dimensional HPLC analysis of amino acids and related compounds in complex matrices; Application to food and extraterrestrial samples (2019)
  • Author(s): K. Hamase
  • Organizer: 35th International Annual Meeting in Pharmaceutical Sciences (IAMPS35) and CU-MPU International Collaborative Research Conference
  • Int'l Joint Research / Invited
• [Presentation] Three-dimensional chiral HPLC analysis of extraterrestrial amino acids in carbonaceous chondrites (2019)
  • Author(s): A. Furusho, T. Akita, M. Mita, H. Naraoka, K. Hamase
  • Organizer: 48th International Symposium on High-Performance Liquid Phase Separations and Related Techniques
  • Int'l Joint Research
• [Presentation] Multi-dimensional HPLC analysis of chiral α-amino acids and carboxylic acids in extraterrestrial materials (2019)
  • Author(s): K. Hamase, A. Furusho, C.-L. Hsieh, R. Koga, T. Akita, M. Mita, H. Naraoka, W. Lindner
  • Organizer: 31st International Symposium on Chirality
  • Int'l Joint Research
• [Presentation] Enantioselective three-dimensional HPLC determination of amino acids in carbonaceous meteorites, (2019)
  • Author(s): A. Furusho, T. Akita, M. Mita, H. Naraoka, K. Hamase
  • Organizer: 49th International Symposium on High Performance Liquid Phase Separations and Related Techniques
  • Int'l Joint Research
• [Presentation] 三次元HPLCを用いる地球外試料中のキラルアミノ酸分析 (2019)
  • Author(s): 古庄仰，秋田健行，三田真史，奈良岡浩，浜瀬健司
  • Organizer: 第79回分析化学討論会
• [Presentation] 高選択的三次元HPLC法の開発と炭素質隕石中のキラルアミノ酸分析 (2019)
  • Author(s): 古庄仰，秋田健行，三田真史，奈良岡浩，浜瀬健司
  • Organizer: アストロバイオロジーワークショップ2019
• [Presentation] 宇宙有機分子の超高分解能質量分析と同位体 (2019)
  • Author(s): 奈良岡浩
  • Organizer: 第17回同位体科学研究会
  • Invited
• [Presentation] Abundant Magnesium-Containing Organic Compounds in the Tagish Lake Meteorite (2019)
  • Author(s): M. Hashiguchi, H. Naraoka
  • Organizer: 50th Lunar Planetary Science Conference
  • Int'l Joint Research
• [Presentation] Formation mechanism of Soluble Organic Compounds in carbonaceous meteorites (2018)
  • Author(s): H. Naraoka
  • Organizer: American Geophysical Union 2018 Fall Meeting
  • Int'l Joint Research / Invited
• [Presentation] Ultrahigh-Resolution Orbitrap Mass Spectral Analyses of Meteoritic Organic Compounds (2018)
  • Author(s): H. Naraoka
  • Organizer: 3rd Korea-Japan Workshop on Isotope-Ratio Mass Spectrometry
  • Int'l Joint Research
• [Presentation] 超高分解能質量分析による宇宙・地球有機化合物の解析 (2018)
  • Author(s): 奈良岡浩
  • Organizer: 2018年度日本地球惑星連合大会
• [Presentation] 隕石中の有機金属化合物の存在 (2018)
  • Author(s): 奈良岡浩, Orthous-Daunay Francois-Regis
  • Organizer: 2018年度日本地球惑星連合大会
  • Int'l Joint Research
• [Presentation] 炭素質隕石中の可溶性有機化合物の生成過程 (2018)
  • Author(s): 奈良岡浩
  • Organizer: 2018年度日本地球化学会年会
• [Presentation] 脱離エレクトロスプレーイオン化法を用いたマーチソン隕石の高分解能イメージング質量分析 (2018)
  • Author(s): 橋口未奈子、奈良岡浩
  • Organizer: 2018年度日本地球惑星連合大会
  • Invited
• [Presentation] タギッシュレイク隕石中のMg含有可溶性有機化合物 (2018)
  • Author(s): 橋口未奈子、奈良岡浩
  • Organizer: 2018年度日本地球化学会年会
• [Presentation] 脱離エレクトロスプレーイオン化法を用いた始原的隕石中の可溶性有機物の高分解能イメージング質量分析 (2018)
  • Author(s): 橋口未奈子、奈良岡浩
  • Organizer: 生命関連分子地球外運搬説ワークショップ
  • Invited
• [Presentation] Analysis of archaeal intact polar membrane lipids in hydrothermal chimneys from Okinawa Trough (2018)
  • Author(s): S. Horai, H. Naraoka, J. Miyazaki
  • Organizer: 2018年度日本地球惑星連合大会
• [Presentation] 高速液体クロマトグラフィー/加熱エレクトロスプレー高分解能質量分析法による古細菌のコア脂質・極性脂質の一斉分析 (2018)
  • Author(s): 宝来俊育、奈良岡浩
  • Organizer: 第36回有機地球化学シンポジウム
• [Presentation] Equilibrium Nitrogen Isotope Fractionation of Hexamethylenetetramine (C6H12N4) in Ammonium Solution (2018)
  • Author(s): 伊佐純子、奈良岡浩
  • Organizer: 2018年度日本地球惑星連合大会
• [Presentation] Multi-dimensional HPLC with fluorescence detection as a promising method for trace analysis of chiral amino acids and hydroxy acids in clinical, food and extraterrestrial samples (2018)
  • Author(s): K. Hamase
  • Organizer: XVIII International Symposium on Luminescence Spectrometry
  • Int'l Joint Research / Invited
• [Presentation] Development of a three-dimensional HPLC system with fluorescence detection for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in human clinical samples (2018)
  • Author(s): C.-L. Hsieh, M. Mita, T. Ide, J.-A. Lee, K. Hamase
  • Organizer: XVIII International Symposium on Luminescence Spectrometry
  • Int'l Joint Research
• [Presentation] DESI-MS imaging of soluble organic compounds in the Murchison meteorite (2018)
  • Author(s): M. Hashiguchi, H. Naraoka
  • Organizer: Solar System Symposium 2018, Hokkaido, Japan
  • Int'l Joint Research
• [Presentation] Investigation of amino acid precursors using HPLC/OrbitrapMS: Attempts to reveal the detailed formation pathways of meteoritic amino acids (2018)
  • Author(s): T. Koga, H. Naraoka, J. Miyazaki
  • Organizer: Solar System Symposium 2018, Hokkaido, Japan
  • Int'l Joint Research
• [Presentation] Multi-dimensional HPLC analysis of chiral amino acids for drug discovery and diagnosis (2017)
  • Author(s): Hamase, K.
  • Organizer: The JSPS-NRCT Follow-Up Seminar 2017 and 33rd International Annual Meeting in Pharmaceutical Sciences
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2017-03-02
  • Int'l Joint Research / Invited
• [Presentation] Multi-dimensional HPLC analysis of extraterrestrial amino acid enantiomers in various cosmic samples (2017)
  • Author(s): R. Koga, Y. Sato, M. Mita, H. Naraoka, K. Hamase
  • Organizer: The 3rd International Conference of D-Amino Acid Research,Varese, Italy
  • Int'l Joint Research / Invited
• [Presentation] Multi-dimensional HPLC analysis of D-amino acids and related compounds in complicated biological matrices and its clinical applications (2017)
  • Author(s): K. Hamase, R. Koga, Y. Miyoshi, M. Mita, J.-A. Lee, W. Lindner
  • Organizer: The 3rd International Conference of D-Amino Acid Research,Varese, Italy
  • Int'l Joint Research / Invited
• [Presentation] Organic compound distribution in asteroidal materials revealed by ultrahigh-resolution mass spectroscopy (2017)
  • Author(s): H. Naraoka
  • Organizer: Astrobiology Science Conference 2017, Arizona, USA
  • Int'l Joint Research
• [Presentation] Trace organic compound analyses of micrometer-sized asteroidal materials (2017)
  • Author(s): H. Naraoka
  • Organizer: 4th Symposium of the Solar System Materials, Tokyo, Japan
  • Int'l Joint Research
• [Presentation] Isotopic and molecular analysis of Antarctic CR chondrites (2017)
  • Author(s): H. Naraoka, M. Hashiguchi
  • Organizer: The 40th Antarctic Meteorite Symposium, Tachikawa, Tokyo
  • Int'l Joint Research
• [Presentation] Soluble high molecular N-heterocycles in the CM and CR chondrites (2017)
  • Author(s): H. Naraoka, M. Hashiguchi
  • Organizer: Goldschmidt Conference 2017, Paris, France
  • Int'l Joint Research
• [Presentation] Chemical imaging of organic compounds in the Murchison meteorite by desorption electrospray ionization coupled with Orbitrap MS (2017)
  • Author(s): M. Hashiguchi, H. Naraoka
  • Organizer: Goldschmidt Conference 2017, Paris, France
  • Int'l Joint Research
• [Presentation] Molecular evolution of meteoritic organics revealed by Orbitrap mass spectrometry coupled with chromatography (2017)
  • Author(s): H. Naraoka
  • Organizer: Fourier Transform Mass Spectrometry Workshop: Mixture Complexity, Data Interpretation, Paris, France
  • Int'l Joint Research
• [Presentation] DESI mapping coupled with Orbitrap-MS (2017)
  • Author(s): M. Hashiguchi, H. Naraoka
  • Organizer: Fourier Transform Mass Spectrometry Workshop: Mixture Complexity, Data Interpretation, Paris, France
  • Int'l Joint Research
• [Presentation] Formose reactions with NH3 prevailing for the synthesis of meteoritic soluble organic matter (2017)
  • Author(s): H. Naraoka
  • Organizer: XVIIIth International Conference on the Origin of Life, California, USA
  • Int'l Joint Research
• [Presentation] The discovery of new meteoritic amino acids in the Murchison meteorite: Implication for new formation mechanisms of meteoritic amino acids (2017)
  • Author(s): T. Koga, H. Naraoka
  • Organizer: XVIIIth International Conference on the Origin of Life, California, USA
  • Int'l Joint Research
• [Presentation] Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human clinical samples using a narrowbore two-dimensional HPLC system (2017)
  • Author(s): C.-L. Hsieh, A. Furusho, M. Mita, T. Ide, J.-A. Lee, K. Hamase
  • Organizer: The 3rd International Conference of D-Amino Acid Research, Varese, Italy
  • Int'l Joint Research
• [Presentation] Molecular evolution of N-containing cyclic compounds in carbonaceous asteroids (2017)
  • Author(s): H. Naraoka
  • Organizer: International Symposium on Molecular Evolution in Space, Hokkaido, Japan
  • Int'l Joint Research
• [Presentation] Three-demensional HPLC analysis of amino acid enantiomers in complicated real world samples (2017)
  • Author(s): K. Hamase, R. Koga, Y. Miyoshi, M. Mita, W. Lindner
  • Organizer: 45th International Symposium on High Performance Liquid Phase Separations and Related Techniques
  • Int'l Joint Research
• [Presentation] Development of high resolusion Pirkle-type chiral stationary phases and application to D-amino acid analysis in biological matrices (2017)
  • Author(s): K. Ueki, T. Akita, Y. Kadota, Y. Nishio, Y. Miyoshi, M. Mita, A. Ojida, K. Hamase
  • Organizer: 45th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Prague, Czech Republic
  • Int'l Joint Research
• [Presentation] 隕石可溶性有機物の化学熱分解／ガスクロマトグラフィー超高分解能質量分析 (2017)
  • Author(s): 奈良岡浩, 横山築, 山本五秋
  • Organizer: 2017年度日本地球化学会第62回年会
• [Presentation] 脱離エレクトロスプレーを用いたMurchison隕石中の極性有機化合物の高分解能質量イメージング (2017)
  • Author(s): 橋口未奈子, 奈良岡浩
  • Organizer: 2017年度日本地球化学会第62回年会
• [Presentation] 古細菌膜脂質のオービトラップ超高分解能質量分析 (2017)
  • Author(s): 奈良岡浩, 宝来俊育, 山内敬明
  • Organizer: 第35回有機地球化学シンポジウム
• [Presentation] New formation mechanisms of meteoritic amino acids based on the discovery of hydroxy amino acids identified in the Murchison meteorite (2017)
  • Author(s): T. Koga, H. Naraoka
  • Organizer: JpGU-AGU Joint Meeting 2017
• [Presentation] Chiral amino acid metabolomics using multi-dimensional HPLC (2016)
  • Author(s): Hamase, K., Koga, R., Akita, T., Miyoshi, Y., Mita, M.,Naraoka, H., Lindner, W.
  • Organizer: XVII International Symposium on Luminescence Spectrometry
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-11-24
  • Int'l Joint Research / Invited
• [Presentation] 惑星微量有機化合物の超高分解能・超感度分析 (2016)
  • Author(s): 奈良岡浩
  • Organizer: 2016年度日本地球化学会第63回年会
  • Place of Presentation: 大阪
  • Year and Date: 2016-09-14
• [Presentation] 二次元キラルHPLCを用いる地球外試料中のα-アミノ酸分析法開発 (2016)
  • Author(s): 佐藤裕，古賀鈴依子，三田真史，奈良岡浩，浜瀬健司
  • Organizer: 第12回D-アミノ酸学会学術講演会
  • Place of Presentation: 高知
  • Year and Date: 2016-09-14
• [Presentation] In-situ organic compound analysis of the meteorite surface by desorption electrospray ionization coupled with an Orbitrap mass spectrometer (2016)
  • Author(s): Naraoka, H and Hashiguchi, M
  • Organizer: Annual Meeting of Meteoritical Society
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2016-08-07
  • Int'l Joint Research
• [Presentation] Recent technical advances in organic geochemistry: High-resolution mass spectral, chromatographic and spatial analyses (2016)
  • Author(s): Naraoka, H
  • Organizer: Workshop on Biomarkers and Molecular Isotopes
  • Place of Presentation: Osaka
  • Year and Date: 2016-07-04
  • Int'l Joint Research / Invited
• [Presentation] Ultrahigh-Resolution Analyses of Trace Organic Compounds for Planetary Materials (2016)
  • Author(s): Naraoka, H.
  • Organizer: Goldschmidt Conference 2016
  • Place of Presentation: Yokohama
  • Year and Date: 2016-06-25
  • Int'l Joint Research
• [Presentation] 地球外有機化合物の超高分解能HPLC-MSによる解析 (2016)
  • Author(s): 奈良岡浩
  • Organizer: 日本地球惑星連合大会2016
  • Place of Presentation: 千葉
  • Year and Date: 2016-05-22
• [Presentation] Extensive alkylated N-containing cyclic compounds in the Murchison meteorite (2016)
  • Author(s): Naraoka, H., Yamashita, Y. and Yamaguchi, M.
  • Organizer: Solar-System Symposium 2016
  • Place of Presentation: Hokkaido, Japan
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] 隕石有機物におけるアルキル化環状同族体化合物 (2015)
  • Author(s): 奈良岡浩
  • Organizer: 2015年度日本地球化学会第62回年会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-09-18
• [Presentation] Meteoritic organic matter synthesis inferred from aldehydes and ammonia with olivine (2015)
  • Author(s): Naraoka, H., Yamashita, Y., Koga, T., Ishibashi, Y. and Mita, H.
  • Organizer: Astrobiology Science Conference 2015
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Remarks] 九州大学「惑星微量有機化合物研究センター」
  • URL: http://www.planetaryorganics.jp/index.html
• [Remarks] 九州大学「惑星微量有機化合物研究センター」科研費基盤研究S紹介
  • URL: http://www.planetaryorganics.jp/kaken.html
• [Remarks] 九州大学「惑星微量有機化合物研究センター」科研費基盤S紹介
  • URL: http://www.planetaryorganics.jp/kaken.html