| Co-Investigator(Kenkyū-buntansha) |
三浦 智也 京都大学, 工学研究科, 准教授 (10378804)
増田 侑亮 京都大学, 工学研究科, 特定助教 (20822307)
石田 直樹 京都大学, 工学研究科, 講師 (70512755)
矢田 陽 京都大学, 工学研究科, 助教 (70619965)
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| Budget Amount *help |
¥200,980,000 (Direct Cost: ¥154,600,000、Indirect Cost: ¥46,380,000)
Fiscal Year 2019: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2018: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2017: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥121,420,000 (Direct Cost: ¥93,400,000、Indirect Cost: ¥28,020,000)
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| Outline of Final Research Achievements |
Synthetic transformations of readily available materials such as hydrocarbons were developed by exploiting light and metal catalysts, providing a straightforward access to valued structural motifs. For example, a C-H bond of simple hydrocarbons was cleaved and CO2 was inserted therein to furnish carboxylic acids. Even saturated hydrocarbons, which are generally unreactive, could be used as the substrates. Also developed were stereoselective synthetic pathways from terminal alkynes to homoallylic alcohols with contiguous stereocenters. The process involves (1) introduction of boron groups onto alkynes to prepare alkenylboranes, (2) transposition of the alkene moiety of the alkenylboranes to generate allylboranes, (3) allylation of aldehydes with the generated allylboranes. A variety of homoallylic alcohols were synthesized in an enantio- and diastereo-selective fashion.
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