| Budget Amount *help |
¥176,540,000 (Direct Cost: ¥135,800,000、Indirect Cost: ¥40,740,000)
Fiscal Year 2019: ¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000)
Fiscal Year 2018: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2017: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2016: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Fiscal Year 2015: ¥39,910,000 (Direct Cost: ¥30,700,000、Indirect Cost: ¥9,210,000)
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| Outline of Final Research Achievements |
Abnormal synaptic connections contribute to various neuropsychiatric, neurodevelopmental and neurological disorders, such as autism spectrum disorders, schizophrenia and Alzheimer’s dementia. However, it has remained largely unclear how vast numbers of connections are precisely established, maintained, and modified throughout life. In this study, we addressed this question by focusing on a new class of synaptic organizers, C1q family proteins. We have demonstrated how Cbln1, C11L1-3 proteins are released and functions in representative neural circuits of the hippocampus and the cerebellum.
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