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Studies in structural physiology of channels

Research Project

Project/Area Number 15H05775
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionTokyo Medical and Dental University (2019)
Nagoya University (2015-2018)

Principal Investigator

FUJIYOSHI Yoshinori  東京医科歯科大学, 高等研究院, 特別栄誉教授 (80142298)

Co-Investigator(Kenkyū-buntansha) 大嶋 篤典  名古屋大学, 細胞生理学研究センター, 教授 (80456847)
谷 一寿  名古屋大学, 細胞生理学研究センター, 特任教授 (20541204)
阿部 一啓  名古屋大学, 細胞生理学研究センター, 准教授 (60596188)
入江 克雅  名古屋大学, 細胞生理学研究センター, 助教 (20415087)
Project Period (FY) 2015-05-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥180,050,000 (Direct Cost: ¥138,500,000、Indirect Cost: ¥41,550,000)
Fiscal Year 2019: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2018: ¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
Fiscal Year 2017: ¥35,360,000 (Direct Cost: ¥27,200,000、Indirect Cost: ¥8,160,000)
Fiscal Year 2016: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2015: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Keywordsクライオ電子顕微鏡 / 構造生理学 / チャネル / 膜タンパク質 / 単粒子解析 / 結晶学 / 構造生物学 / 単粒子解析法 / 膜タンパク質の生理機能 / 電子線結晶学
Outline of Final Research Achievements

Structural information of membrane proteins including channels is crucial toward gaining a better understanding of biologic functions. The information that can be gained from a protein structure strongly depends on its resolution - the higher the resolution, the more insight gained into the structure-function relationship of biologic macromolecules. We analyzed structures of proton pump, water channel AQP4, whose inhibitor could be a drug for brain edema, Na+ channel, gap junction channels and tight junction channels at high resolutions. While we could not get significant results of AChR, we analyzed structures of endothelin receptor and its complexes with the agonist and antagonists. In this project, we could get important knowledge in the research field named as structural physiology and partly elucidate how the channels work and regulate functions of the human body. We also contributed advancement of cryo-electron microscopy by developing cryo-electron microscopes.

Academic Significance and Societal Importance of the Research Achievements

構造研究が困難とされてきた膜タンパク質の構造を高い分解能で解析するための技術開発を進め、チャネルを中心とする構造を実際に解析して、構造生理学的に詳細に理解することができるようにした。2報のNature誌の論文をはじめ着実な論文発表を行った。特に、急激に発展しつつあり、創薬の分野でも注目を集めつつあるクライオ電子顕微鏡を用いた構造研究分野で、装置開発や関連技術開発などの貢献をした。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2020 Research Progress Assessment (Verification Result) ( PDF )
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (65 results)

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article (18 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 18 results,  Open Access: 15 results,  Acknowledgement Compliant: 9 results) Presentation (43 results) (of which Int'l Joint Research: 19 results,  Invited: 42 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence2020

    • Author(s)
      Shimomura Takushi、Yonekawa Yoshiki、Nagura Hitoshi、Tateyama Michihiro、Fujiyoshi Yoshinori、Irie Katsumasa
    • Journal Title

      eLife

      Volume: 9 Pages: 1-21

    • DOI

      10.7554/elife.52828

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids2020

    • Author(s)
      Burendei Batuujin、Shinozaki Ruriko、Watanabe Masakatsu、Terada Tohru、Tani Kazutoshi、Fujiyoshi Yoshinori、Oshima Atsunori
    • Journal Title

      Science Advances

      Volume: 6 Issue: 7

    • DOI

      10.1126/sciadv.aax3157

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A single K+-binding site in the crystal structure of the gastric proton pump2019

    • Author(s)
      Yamamoto Kenta、Dubey Vikas、Irie Katsumasa、Nakanishi Hanayo、Khandelia Himanshu、Fujiyoshi Yoshinori、Abe Kazuhiro
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.47701

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Morphologic determinant of tight junctions revealed by claudin-3 structures2019

    • Author(s)
      Nakamura Shun、Irie Katsumasa、Tanaka Hiroo、Nishikawa Kouki、Suzuki Hiroshi、Saitoh Yasunori、Tamura Atsushi、Tsukita Sachiko、Fujiyoshi Yoshinori
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 816-816

    • DOI

      10.1038/s41467-019-08760-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy2019

    • Author(s)
      Yamaguchi Hiroki、Kamegawa Akiko、Nakata Kunio、Kashiwagi Tatsuki、Mizukoshi Toshimi、Fujiyoshi Yoshinori、Tani Kazutoshi
    • Journal Title

      Journal of Structural Biology

      Volume: 205 Issue: 1 Pages: 11-21

    • DOI

      10.1016/j.jsb.2018.12.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structures of the gastric proton pump2018

    • Author(s)
      Abe Kazuhiro、Irie Katsumasa、Nakanishi Hanayo、Suzuki Hiroshi、Fujiyoshi Yoshinori
    • Journal Title

      Nature

      Volume: 556 Issue: 7700 Pages: 214-218

    • DOI

      10.1038/s41586-018-0003-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog2017

    • Author(s)
      Shihoya Wataru、Nishizawa Tomohiro、Yamashita Keitaro、Inoue Asuka、Hirata Kunio、Kadji Francois Marie Ngako、Okuta Akiko、Tani Kazutoshi、Aoki Junken、Fujiyoshi Yoshinori、Doi Tomoko、Nureki Osamu
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 24 Issue: 9 Pages: 758-764

    • DOI

      10.1038/nsmb.3450

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors2017

    • Author(s)
      Abe Kazuhiro、Shimokawa Jun、Naito Mao、Munson Keith、Vagin Olga、Sachs George、Suzuki Hiroshi、Tani Kazutoshi、Fujiyoshi Yoshinori
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 6632-6632

    • DOI

      10.1038/s41598-017-06698-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structures of claudins: insights into their intermolecular interactions.2017

    • Author(s)
      H. Suzuki, K. Tani, Y. Fujiyoshi
    • Journal Title

      Ann. N. Y. Acad. Sci.

      Volume: N/A Issue: 1 Pages: 25-34

    • DOI

      10.1111/nyas.13371

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thermostabilization of the human endothelin type-B receptor2016

    • Author(s)
      Akiko Okuta, Kazutoshi Tani, Shoko Nishimura, Yoshinori Fujiyoshi, and Tomoko Doi*
    • Journal Title

      Journal of Molecular Biology

      Volume: in press Issue: 11 Pages: 1-10

    • DOI

      10.1016/j.jmb.2016.03.024

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics.2016

    • Author(s)
      T. Shimomura, K. Irie and Y. Fujiyoshi
    • Journal Title

      FEBS Journal

      Volume: 283 Issue: 15 Pages: 2881-2895

    • DOI

      10.1111/febs.13776

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Activation mechanism of endothelin ETB receptor by endothelin-1.2016

    • Author(s)
      W. Shihoya, T. Nishizawa, A. Okuta, K. Tani, N. Dohmae, Y. Fujiyoshi, O. Nureki and T. Doi
    • Journal Title

      Nature

      Volume: 537 Issue: 7620 Pages: 363-368

    • DOI

      10.1038/nature19319

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Atomic structure of the innexin-6 gap junction channel determined by cryo-EM.2016

    • Author(s)
      A. Oshima, K. Tani and Y. Fujiyoshi
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 13681-13681

    • DOI

      10.1038/ncomms13681

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of physiologic phenotypes of dentate gyrus synapses of PDZ1/2 domain-deficient PSD-95 knockin mice.2016

    • Author(s)
      H. Nagura, T. Doi and Y. Fujiyoshi
    • Journal Title

      European Journal of Neuroscience

      Volume: 43 Issue: 5 Pages: 618-625

    • DOI

      10.1111/ejn.13155

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Claudin-21 has a paracellular channel role at tight junctions2016

    • Author(s)
      Claudin-21 Has a Paracellular Channel Role at Tight Junctions.
    • Journal Title

      Mol Cell Biol.

      Volume: 36 Issue: 6 Pages: 954

    • DOI

      10.1128/mcb.00758-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide.2016

    • Author(s)
      A. Kamegawa, Y. Hiroaki, K. Tani, and Y. Fujiyoshi
    • Journal Title

      Microscopy

      Volume: 65 Issue: 2 Pages: 177-184

    • DOI

      10.1093/jmicro/dfv368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An intracellular domain with a novel sequence regulates cell surface expression and synaptic clustering of leucine-rich repeat transmembrane proteins in hippocampal neurons.2015

    • Author(s)
      K. Minatohara, Y. Murata, Y. Fujiyoshi and T. Doi
    • Journal Title

      Journal of Neurochemistry

      Volume: 134 Issue: 4 Pages: 618-628

    • DOI

      10.1111/jnc.13159

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GraDeR: membrane protein complex preparation for single particle cryo-EM.2015

    • Author(s)
      Hauer F., Gerle C., Fischer N., Oshima A., Shinzawa-Itoh K., Shimada S., Yokoyama K., Fujiyoshi Y. & Stark H.
    • Journal Title

      Structure

      Volume: 23 Issue: 9 Pages: 1769-1775

    • DOI

      10.1016/j.str.2015.06.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] クライオ電顕が医学・薬学分野に役立つ時代に2020

    • Author(s)
      藤吉好則
    • Organizer
      nano tech 2020 特別シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] クライオ電子顕微鏡を用いた構造創薬の現状2019

    • Author(s)
      藤吉好則
    • Organizer
      第13回 In vivo実験医学シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Cryo-EM changes structural biology [Tutorial Lecture]2019

    • Author(s)
      藤吉好則
    • Organizer
      ALC '19
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structure-guided drug development by cryo-EM [Plenary Lecture]2019

    • Author(s)
      藤吉好則
    • Organizer
      International Symposium on Diffraction Structural Biology 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Drug rescuing based on structure analyses by cryo-EM2019

    • Author(s)
      藤吉好則
    • Organizer
      インベスターR&D Day
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] クライオ電子顕微鏡による構造解析と構造創薬2019

    • Author(s)
      藤吉好則
    • Organizer
      クリニカルサミット研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 構造生物学を激変させたクライオ電顕2019

    • Author(s)
      藤吉好則
    • Organizer
      第二回 形態解析ワークショップ ― 多様な顕微鏡を用いて
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生体分子を観ると創薬に役立つ2019

    • Author(s)
      藤吉好則
    • Organizer
      日本顕微鏡学会市民公開講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Structural physiology of channels [Special Lecture]2019

    • Author(s)
      藤吉好則
    • Organizer
      倉智嘉久教授退職記念国際シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microscopyシンポジウム「顕微鏡分野における世界の学術出版動向」2018

    • Author(s)
      藤吉好則
    • Organizer
      日本顕微鏡学会 第74回学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 構造生物学を激変させたクライオ電顕2018

    • Author(s)
      藤吉好則
    • Organizer
      岡山大学 特別講演会・学院講義
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] セッション4 クライオ電顕の現状と展望[ディスカッションリーダー]2018

    • Author(s)
      藤吉好則
    • Organizer
      原子・分子・光科学(AMO)討論会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Drug Rescuing by Cryo-EM2018

    • Author(s)
      藤吉好則
    • Organizer
      第18回国際薬理学・臨床薬理学会議
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 構造生理学と創薬2018

    • Author(s)
      藤吉好則
    • Organizer
      第58回生物物理若手の会 夏の学校
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 構造生物学を激変させたクライオ電顕2018

    • Author(s)
      藤吉好則
    • Organizer
      第34回 分析電子顕微鏡討論会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] High resolution structure analyses by cryo-EM2018

    • Author(s)
      藤吉好則
    • Organizer
      Scottish Centre for Macromolecular Imaging Opening Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structure-guided drug development by Cryo-EM [Keynote]2018

    • Author(s)
      藤吉好則
    • Organizer
      The official Opening of the electron Bio-Imaging Centre (eBIC) at Diamond Light Source
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural physiology of membrane proteins2018

    • Author(s)
      藤吉好則
    • Organizer
      Special Seminar at MRC-LMB
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Drug Rescuing based on structure analyses by Cryo-EM2018

    • Author(s)
      藤吉好則
    • Organizer
      2018 International Meeting on 22nd MDO/33rd JSSX
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Drug Rescuing Based on Structure Analyses by Cryo-EM2018

    • Author(s)
      藤吉好則
    • Organizer
      CryoEM Symposium "The Cryo-EM Revolution and Future Breakthroughs"
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] クライオ電顕法の発展と創薬応用への可能性2018

    • Author(s)
      藤吉好則
    • Organizer
      平成30年度 後期(秋季)有機合成化学講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] クライオ電顕法を用いた構造解析と医薬応用2018

    • Author(s)
      藤吉好則
    • Organizer
      東京医科歯科大学 難治疾患研究所 講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structure-Guided Drug Development by CryoEM2017

    • Author(s)
      藤吉好則
    • Organizer
      International Symposium on Cryo-EM - past and future challenges
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 構造生物学を激変させたクライオ電子顕微鏡法2017

    • Author(s)
      藤吉好則
    • Organizer
      CSJ化学フェスタ2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 構造生物学を激変させたCryoEM2017

    • Author(s)
      藤吉好則
    • Organizer
      微細構造解析プラットフォームシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Structures of membrane proteins analyzed by cryo-EM2017

    • Author(s)
      藤吉好則
    • Organizer
      新学術領域研究「脂質クオリティが解き明かす生命現象」公開国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structures of Physiology of membrane proteins2017

    • Author(s)
      藤吉好則
    • Organizer
      International Cryo-EM symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] For effective structure analyses of membrane proteins2017

    • Author(s)
      藤吉好則
    • Organizer
      Symposium to celebrate Gunnar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 創薬に役立つCryoEM2017

    • Author(s)
      藤吉好則
    • Organizer
      第30回バイオメディカル分析化学シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural studies of membrane proteins by cryo-EM2017

    • Author(s)
      藤吉好則
    • Organizer
      第17回日本タンパク質科学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 膜タンパク質の構造生理学2017

    • Author(s)
      藤吉好則
    • Organizer
      日本膜学会第39年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 構造生物学の激変2017

    • Author(s)
      藤吉 好則
    • Organizer
      生理学研究所 平成28年度末シンポジウム
    • Place of Presentation
      生理学研究所
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 構造に指南された創薬戦略の現状と展望2016

    • Author(s)
      藤吉 好則
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of the structural biology field2016

    • Author(s)
      Yoshinori Fujiyoshi
    • Organizer
      THE 13TH NIKKO INTERNATIONAL SYMPOSIUM 2016
    • Place of Presentation
      自治医科大学
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural physiology of channels2016

    • Author(s)
      Yoshinori Fujiyoshi
    • Organizer
      内藤コンファレンス -In the Vanguard of Structural Biology: Revolutionizing Life Sciences-
    • Place of Presentation
      シャトレーゼ ガトーキングダム 札幌
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dramatic Changes on Cryo-Electron Microscopy2016

    • Author(s)
      Yoshinori Fujiyoshi
    • Organizer
      The XXVIIth International Conference on Magnetic Resonance in Biological Systems (ICMRBS2016)
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Issues to Be Considered for Image Based Structure Analysis2016

    • Author(s)
      Yoshinori Fujiyoshi
    • Organizer
      Gordon Research Conferences -Three Dimensional Electron Microscopy-
    • Place of Presentation
      The Chinese University of Hong Kong Hong Kong, China
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 構造に指南された創薬基盤技術開発2016

    • Author(s)
      藤吉好則
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 薬理学につながる構造生理学研究2016

    • Author(s)
      藤吉好則
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Structural physiology of cell adhesive channels2015

    • Author(s)
      藤吉好則
    • Organizer
      第31回国際生物学賞記念シンポジウム
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 素朴な疑問と続ける努力2015

    • Author(s)
      藤吉好則
    • Organizer
      Biochemistry and Molecular Biology 2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Structure-Guided Drug Development Based on Cryo-Electron Microscopy2015

    • Author(s)
      藤吉好則
    • Organizer
      The 2nd East-Asia Microscopy Conference
    • Place of Presentation
      姫路商工会議所
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] タンパク質と脂質分子の協調2015

    • Author(s)
      藤吉好則
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 東京医科歯科大学高等研究院卓越研究部門細胞構造生理学研究室ホームページ

    • URL

      http://www.tmd.ac.jp/cesp/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 名古屋大学 細胞生理学研究センター

    • URL

      http://www.cespi.nagoya-u.ac.jp/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 細胞生理学研究センター

    • URL

      http://www.cespi.nagoya-u.ac.jp/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 3次元像構築方法、画像処理装置、および電子顕微鏡(再公表特許)2015

    • Inventor(s)
      藤吉 好則、石川 勇、細木 直樹
    • Industrial Property Rights Holder
      国立大学法人名古屋大学、日本電子株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas

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Published: 2015-06-03   Modified: 2023-10-16  

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