| Budget Amount *help |
¥192,010,000 (Direct Cost: ¥147,700,000、Indirect Cost: ¥44,310,000)
Fiscal Year 2019: ¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2018: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2017: ¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
Fiscal Year 2016: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Fiscal Year 2015: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
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| Outline of Final Research Achievements |
Bile acids are secreted into the upper small intestine upon ingestion, and then taken up in the lower small intestine and returned to the liver. Since a portion of bile acids flow into the systemic bloodstream, the bile acid concentration in the blood increases after eating, which is considered to be a feeding signal. The target molecule that recognizes this is the bile acid receptor TGR5. For functional analysis in skeletal muscle, transgenic mice expressing human TGR5 in skeletal muscle were established and analyzed. It was found that activation of TGR5 by bile acid resulted in a muscle hypertrophy effect. When an oral glucose tolerance test was performed, a rapid decrease in blood glucose was confirmed, and it was clarified that an increase in muscle mass leads to an improvement in glucose intolerance. Part of the increase in muscle mass associated with the feeding response may be due to TGR5 function.
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