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Platform for the identification of novel therapeutically effective antimicrobial agents

Research Project

Project/Area Number 15H05783
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Environmental and hygienic pharmacy
Research InstitutionTeikyo University (2016-2019)
The University of Tokyo (2015)

Principal Investigator

Kazuhisa Sekimizu  帝京大学, 医真菌研究センター, 教授 (90126095)

Co-Investigator(Kenkyū-buntansha) 垣内 力  岡山大学, 医歯薬学総合研究科, 教授 (60420238)
浜本 洋  帝京大学, 医真菌研究センター, 准教授 (90361609)
松本 靖彦  帝京大学, 医真菌研究センター, 講師 (60508141)
Project Period (FY) 2015-05-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥200,850,000 (Direct Cost: ¥154,500,000、Indirect Cost: ¥46,350,000)
Fiscal Year 2019: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2018: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2017: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2016: ¥51,480,000 (Direct Cost: ¥39,600,000、Indirect Cost: ¥11,880,000)
Fiscal Year 2015: ¥60,710,000 (Direct Cost: ¥46,700,000、Indirect Cost: ¥14,010,000)
Keywords微生物 / 病原性 / 網羅的遺伝子発現解析 / 遺伝子機能解析 / 阻害薬 / 感染症 / 薬学 / カイコ / 発現解析 / 抗菌薬 / ncRNA / 発現抑制 / 発現制御
Outline of Final Research Achievements

In this study, we established an exhaustive gene expression analysis method for pathogens in the host environment using next generation sequencer and were able to elucidate in detail the responses of bacteria and fungi to the host environment. We also identified a comprehensive set of virulence factors and successfully identified 20 novel factors in Staphylococcus aureus and more than 30 in Cryptococcus neoformans. We clarified the various functions of these genes in the pathogenicity by biological and genetical methods. Furthermore, we established assay systems for identification of inhibitors for these gene products and identified candidate compounds. These results give novel insight of expression of virulence mechanisms and established a novel method to develop therapeutic options for infectious diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、黄色ブドウ球菌やクリプトコッカスなどの病原体の病原性を網羅的に解析する手法が確立した。特に黄色ブドウ球菌においては、その病原性に関与する新規遺伝子をほぼ網羅的に解析できたと考えられる。また、本研究結果は、細菌、真菌の病原性の詳細を明らかにする基盤的なデータとなり得る。さらに、明らかにした病原性の発揮機構は、従来の系統とは大きく異なっており、病原体の病原性において新たな概念を見出しつつある。さらに、本研究で開発した病原性発揮機構を標的とした阻害薬探索法は、新規感染症治療薬開発に応用可能であり、深刻な問題となっている多剤耐性菌や新興感染症に対抗する新たな手段を提供するものである。

Assessment Rating
Verification Result (Rating)

B

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2020 Research Progress Assessment (Verification Result) ( PDF )
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (131 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (61 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 59 results,  Open Access: 52 results,  Acknowledgement Compliant: 11 results) Presentation (65 results) (of which Int'l Joint Research: 17 results,  Invited: 26 results) Remarks (3 results)

  • [Int'l Joint Research] University of Veterinary Medicine Vienna(オーストリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Veterinary Medicine Vienna(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an <i>in vivo</i> evaluation system and inhibit glucose uptake by human intestinal cells2020

    • Author(s)
      Matsumoto Yasuhiko、Takahashi Miki、Sekimizu Kazuhisa
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 14 Issue: 1 Pages: 8-13

    • DOI

      10.5582/ddt.2020.01002

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2020-02-29
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter2020

    • Author(s)
      Chikara Kaito、Hirono Yoshikai、Ai Wakamatsu、Atsushi Miyashita、Yasuhiko Matsumoto、Tomoko Fujiyuki、Masaru Kato、Yoshitoshi Ogura、Tetsuya Hayashi、Takao Isogai、Kazuhisa Sekimizu
    • Journal Title

      PLOS pathogens

      Volume: -

    • NAID

      120006860101

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Large-scale screening and identification of novel pathogenic staphylococcus aureus genes using a silkworm infection model2020

    • Author(s)
      Paudel Atmika、Hamamoto Hiroshi、Panthee Suresh、Matsumoto Yasuhiko、Sekimizu Kazuhisa
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 221 Issue: 11 Pages: 1795

    • DOI

      10.1093/infdis/jiaa004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms2019

    • Author(s)
      Matsumoto Yasuhiko、Takahashi Miki、Umehara Masahiro、Asano Masato、Maruki-Uchida Hiroko、Morita Minoru、Sekimizu Kazuhisa
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 13 Issue: 5 Pages: 244-247

    • DOI

      10.5582/ddt.2019.01069

    • NAID

      130007744553

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2019-10-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of <i>Trichophyton</i> spp. from footwear of patients with tinea pedis2019

    • Author(s)
      Ishijima Sanae A.、Hiruma Masataro、Sekimizu Kazuhisa、Abe Shigeru
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 13 Issue: 4 Pages: 207-211

    • DOI

      10.5582/ddt.2019.01060

    • NAID

      130007709069

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2019-08-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment2019

    • Author(s)
      Nwibo Daniel Don、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 13 Issue: 3 Pages: 145-149

    • DOI

      10.5582/ddt.2019.01031

    • NAID

      130007682088

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2019-06-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Additive effects of Kothala himbutu (<i>Salacia reticulata</i>) extract and a lactic acid bacterium (<i>Enterococcus faecalis</i> YM0831) for suppression of sucrose-induced hyperglycemia in an <i>in vivo </i>silkworm evaluation system2019

    • Author(s)
      Ishii Masaki、Matsumoto Yasuhiko、Katada Toshiaki、Sekimizu Kazuhisa
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 13 Issue: 3 Pages: 133-136

    • DOI

      10.5582/ddt.2019.01025

    • NAID

      130007682072

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2019-06-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis.2019

    • Author(s)
      Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S.
    • Journal Title

      Appl Environ Microbiol

      Volume: 85 Issue: 21

    • DOI

      10.1128/aem.01428-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph2019

    • Author(s)
      Ryuno, H., Nigo, F., Naguro, I., Sekimizu, K., and Kaito, C.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 5 Pages: e0217517-e0217517

    • DOI

      10.1371/journal.pone.0217517

    • NAID

      120006780367

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GPI0363 inhibits the interaction of RNA polymerase with DNA in: Staphylococcus aureus2019

    • Author(s)
      Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 65 Pages: 37889

    • DOI

      10.1039/c9ra06844a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis2019

    • Author(s)
      Panthee Suresh、Paudel Atmika、Blom Jochen、Hamamoto Hiroshi、Sekimizu Kazuhisa
    • Journal Title

      Frontiers in Microbiology

      Volume: 10 Pages: 1619-1619

    • DOI

      10.3389/fmicb.2019.01619

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of 2H phosphoesterase superfamily proteins with 2′-CPDase activity2019

    • Author(s)
      Mitsutomi Shuhei、Akimitsu Nobuyoshi、Sekimizu Kazuhisa、Kaito Chikara
    • Journal Title

      Biochimie

      Volume: 165 Pages: 235

    • DOI

      10.1016/j.biochi.2019.08.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E2019

    • Author(s)
      Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2992-2992

    • DOI

      10.1038/s41467-019-10754-4

    • URL

      https://localhost/en/publications/deb76592-25dc-4d98-9c1c-937b2cafc9e7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pharmacokinetics of anti-infectious reagents in silkworms2019

    • Author(s)
      Hamamoto Hiroshi、Horie Ryo、Sekimizu Kazuhisa
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 9451-9451

    • DOI

      10.1038/s41598-019-46013-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans2019

    • Author(s)
      Matsumoto Yasuhiko、Ishii Masaki、Hasegawa Setsuo、Sekimizu Kazuhisa
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 157-157

    • DOI

      10.1038/s42003-019-0407-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silkworm as an experimental animal for research on fungal infections2019

    • Author(s)
      Matsumoto Yasuhiko、Sekimizu Kazuhisa
    • Journal Title

      Microbiology and Immunology

      Volume: 63 Issue: 2 Pages: 41

    • DOI

      10.1111/1348-0421.12668

    • NAID

      40021840652

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a gnotobiotic silkworm model2018

    • Author(s)
      Nakajima H, Matsumoto Y, Sekimizu K
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 12 Issue: 5 Pages: 291-294

    • DOI

      10.5582/ddt.2018.01048

    • NAID

      130007521061

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2018-10-31
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms2018

    • Author(s)
      Ishii M, Matsumoto Y, Sekimizu K
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 12 Issue: 4 Pages: 185-188

    • DOI

      10.5582/ddt.2018.01040

    • NAID

      130007484445

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2018-08-31
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an <i>in vivo</i> evaluation system2018

    • Author(s)
      Ishii M, Matsumoto Y, Sekimizu K
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 12 Issue: 3 Pages: 122-125

    • DOI

      10.5582/ddt.2018.01028

    • NAID

      130007403869

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2018-06-30
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of lactic acid bacterial cell number by DNA quantification2018

    • Author(s)
      Ishii M, Matsumoto Y, Sekimizu K
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 12 Issue: 2 Pages: 88-91

    • DOI

      10.5582/ddt.2018.01019

    • NAID

      130006734006

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2018-04-30
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model2018

    • Author(s)
      Paudel Atmika、Panthee Suresh、Urai Makoto、Hamamoto Hiroshi、Ohwada Tomohiko、Sekimizu Kazuhisa
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1578-1578

    • DOI

      10.1038/s41598-018-19867-0

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utilization of hybrid assembly approach to determine the genome of an opportunistic pathogenic fungus, candida albicans timm17682018

    • Author(s)
      Panthee Suresh、Hamamoto Hiroshi、Ishijima Sanae A、Paudel Atmika、Sekimizu Kazuhisa
    • Journal Title

      Genome Biology and Evolution

      Volume: 10 Issue: 8 Pages: 2017

    • DOI

      10.1093/gbe/evy166

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological activities and antibacterial biomarker of <i>Sesbania grandiflora</i> bark extract2017

    • Author(s)
      Anantaworasakul P、Hamamoto H、Sekimizu K、Okonogi S
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 2 Pages: 70-77

    • DOI

      10.5582/ddt.2017.01013

    • NAID

      130007040199

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions2017

    • Author(s)
      Fujino Haruka、Nagatomo Masanori、Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa、Inoue Masayuki
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 39 Pages: 11865

    • DOI

      10.1002/anie.201706671

    • URL

      https://pure.teikyo.jp/en/publications/8dbc5cee-87b8-4d2b-bcf2-826e773397b5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria2017

    • Author(s)
      Ishii M, Matsumoto Y, Nishida S, Sekimizu K
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 1 Pages: 30-34

    • DOI

      10.5582/ddt.2016.01079

    • NAID

      130005466206

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis2017

    • Author(s)
      Ishii Masaki、Matsumoto Yasuhiko、Yamada Tsuyoshi、Abe Shigeru、Sekimizu Kazuhisa
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12289-12289

    • DOI

      10.1038/s41598-017-12523-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic2017

    • Author(s)
      Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 83 Issue: 13 Pages: 6924

    • DOI

      10.1021/acs.joc.7b02318

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of clove oil and eugenol on muscle contraction of silkworm (<i>Bombyx mori</i>)2017

    • Author(s)
      Kheawfu K, Pikulkaew S, Hamamoto H, Sekimizu K, Okonogi S
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 2 Pages: 64-69

    • DOI

      10.5582/ddt.2017.01012

    • NAID

      130007040200

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two-spotted cricket as an animal infection model of human pathogenic fungi2017

    • Author(s)
      Kochi Yuto、Matsumoto Yasuhiko、Sekimizu Kazuhisa、Kaito Chikara
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 5 Pages: 259-266

    • DOI

      10.5582/ddt.2017.01052

    • NAID

      130006210824

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation of antibiotic-producing <i>Pseudomonas</i> species with low-temperature cultivation of temperate soil2017

    • Author(s)
      Mitsutomi S, Sekimizu K, Kaito C
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 5 Pages: 267-275

    • DOI

      10.5582/ddt.2017.01053

    • NAID

      130006210826

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactobacillus paraplantarum 11-1 isolated from rice bran pickles activated innate immunity and improved survival in a silkworm bacterial infection model2017

    • Author(s)
      Nishida Satoshi、Ishii Masaki、Nishiyama Yayoi、Abe Shigeru、Ono Yasuo、Sekimizu Kazuhisa
    • Journal Title

      Front Microbiol

      Volume: 8 Issue: MAR Pages: 436-436

    • DOI

      10.3389/fmicb.2017.00436

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic analysis of vancomycin-resistant <i>Staphylococcus aureus </i>VRS3b and its comparison with other VRSA isolates2017

    • Author(s)
      Panthee S, Hamamoto H, Paudel A, Sekimizu K
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 2 Pages: 78-83

    • DOI

      10.5582/ddt.2017.01024

    • NAID

      130007040198

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b2017

    • Author(s)
      Panthee S, Paudel A, Hamamoto H, Sekimizu K
    • Journal Title

      Genome Announc

      Volume: 5 Issue: 22

    • DOI

      10.1128/genomea.00452-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel spiro-heterocyclic compound identified by the silkworm infection model inhibits transcription in Staphylococcus aureus2017

    • Author(s)
      Paudel Atmika、Hamamoto Hiroshi、Panthee Suresh、Kaneko Keiichi、Matsunaga Shigeki、Kanai Motomu、Suzuki Yutaka、Sekimizu Kazuhisa
    • Journal Title

      Front Microbiol

      Volume: 8 Issue: APR Pages: 712-712

    • DOI

      10.3389/fmicb.2017.00712

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus2017

    • Author(s)
      Tabuchi Fumiaki、Matsumoto Yasuhiko、Ishii Masaki、Tatsuno Keita、Okazaki Mitsuhiro、Sato Tomoaki、Moriya Kyoji、Sekimizu Kazuhisa
    • Journal Title

      Journal of Antibiotics

      Volume: 70 Issue: 8 Pages: 907

    • DOI

      10.1038/ja.2017.56

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis2017

    • Author(s)
      Yagi Akiho、Uchida Ryuji、Hamamoto Hiroshi、Sekimizu Kazuhisa、Kimura Ken-ichi、Tomoda Hiroshi
    • Journal Title

      The Journal of Antibiotics

      Volume: 70 Issue: 5 Pages: 685

    • DOI

      10.1038/ja.2017.23

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from <i>Rhizobium</i> sp. strain M2 screened using a silkworm muscle contraction assay2017

    • Author(s)
      Urai Makoto、Aizawa Tomoko、Imamura Katsutoshi、Hamamoto Hiroshi、Sekimizu Kazuhisa
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 11 Issue: 5 Pages: 238-245

    • DOI

      10.5582/ddt.2017.01045

    • NAID

      130006210838

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms2017

    • Author(s)
      Anantaworasakul, P., Hamamoto, H., Sekimizu, K., and Okonogi, S.
    • Journal Title

      Pharm Biol

      Volume: 55 Issue: 1 Pages: 1256

    • DOI

      10.1080/13880209.2017.1297467

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-52017

    • Author(s)
      Panthee, S., Hamamoto, H., Suzuki, Y., and Sekimizu, K.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 70 Issue: 2 Pages: 204

    • DOI

      10.1038/ja.2016.102

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Advantages of the silkworm as an animal model for developing novel antimicrobial agents2017

    • Author(s)
      Panthee, S., Paudel, A., Hamamoto, H., and Sekimizu, K.
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Issue: MAR

    • DOI

      10.3389/fmicb.2017.00373

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus2017

    • Author(s)
      Tabuchi, F., Matsumoto, Y., Ishii, M., Tatsuno, K., Okazaki, M., Sato, T., Moriya, K., and Sekimizu, K.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 70 Issue: 6 Pages: 771

    • DOI

      10.1038/ja.2017.7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection2017

    • Author(s)
      Nakamura, I., Kanasaki, R., Yoshikawa, K., Furukawa, S., Fujie, A., Hamamoto, H., and Sekimizu, K.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 70 Issue: 1 Pages: 41

    • DOI

      10.1038/ja.2016.106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity2016

    • Author(s)
      T. Kaji, M. Murai, H. Itoh, J. Yasukawa, H. Hamamoto, K. Sekimizu, M. Inoue
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 47 Pages: 16912

    • DOI

      10.1002/chem.201604022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cell-surface phenol soluble modulins regulate staphylococcus aureus colony spreading2016

    • Author(s)
      Kizaki, H., Omae, Y., Tabuchi, F., Saito, Y., Sekimizu, K., and Kaito, C.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0164523-e0164523

    • DOI

      10.1371/journal.pone.0164523

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus2016

    • Author(s)
      Kochi, Y., Miyashita, A., Tsuchiya, K., Mitsuyama, M., Sekimizu, K., and Kaito, C.
    • Journal Title

      FEMS Microbiol Lett

      Volume: 363 Issue: 15 Pages: fnw163-fnw163

    • DOI

      10.1093/femsle/fnw163

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces2016

    • Author(s)
      Nakadai, M., Tomida, S., and Sekimizu, K.
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 18543-18543

    • DOI

      10.1038/srep18543

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A silkworm infection model to investigate Vibrio vulnificus virulence genes2016

    • Author(s)
      Yamamoto, M., Kashimoto, T., Yoshimura, Y., Tachibana, N., Kuroda, S., Miki, Y., Kitabayashi, S., Tong, P., Xiao, J., Tanaka, K., Hamamoto, H., Sekimizu, K., and Yamamoto, K.
    • Journal Title

      Mol Med Rep

      Volume: 14 Issue: 5 Pages: 4243

    • DOI

      10.3892/mmr.2016.5782

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lysobacter species: a potential source of novel antibiotics2016

    • Author(s)
      Panthee, S., Hamamoto, H., Paudel, A., and Sekimizu, K.
    • Journal Title

      Archives of microbiology

      Volume: 198 Issue: 9 Pages: 839

    • DOI

      10.1007/s00203-016-1278-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Menaquinone as a potential target of antibacterial agents2016

    • Author(s)
      Paudel, A., Hamamoto, H., Panthee, S., and Sekimizu, K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 3 Pages: 123-128

    • DOI

      10.5582/ddt.2016.01041

    • NAID

      130005167357

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acute oral toxicity test of chemical compounds in silkworms2016

    • Author(s)
      Usui K, Nishida S, Sugita T, Ueki T, Matsumoto Y, Okumura H, Sekimizu K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 57-61

    • DOI

      10.5582/ddt.2016.01025

    • NAID

      130005133319

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using silkworms as a laboratory animal to evaluate medicines and foods2016

    • Author(s)
      Sekimizu, K. Hamamoto, H.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 1-2

    • DOI

      10.5582/ddt.2016.01018

    • NAID

      130005133320

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Evaluation of anti-diabetic drugs by using silkworm, <i>Bombyx mori </i>2016

    • Author(s)
      Matsumoto Y, Sekimizu K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 19-23

    • DOI

      10.5582/ddt.2016.01017

    • NAID

      130005133326

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine2016

    • Author(s)
      Matsumoto Y, Sekimizu K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 14-18

    • DOI

      10.5582/ddt.2016.01016

    • NAID

      130005133328

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of silkworm as a host animal for understanding pathogenicity of <i>Cryptococcus neoformans </i>2016

    • Author(s)
      Ishii M, Matsumoto Y, Sekimizu K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 9-13

    • DOI

      10.5582/ddt.2016.01015

    • NAID

      130005133327

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury2016

    • Author(s)
      Inagaki Y, Matsumoto Y, Sekimizu K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 40-43

    • DOI

      10.5582/ddt.2016.01023

    • NAID

      130005133318

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of lysocin E using a silkworm model of bacterial infection2016

    • Author(s)
      Hamamoto, H. Sekimizu, K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 24-29

    • DOI

      10.5582/ddt.2016.01012

    • NAID

      130005133325

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Multidrug-resistance transporter AbcA secretes staphylococcus aureus cytolytic toxins2016

    • Author(s)
      Yoshikai, H. Kizaki, H. Saito, Y. Omae, Y. Sekimizu, K. Kaito, C.
    • Journal Title

      J Infect Dis

      Volume: 213 Issue: 2 Pages: 295

    • DOI

      10.1093/infdis/jiv376

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm2016

    • Author(s)
      Nishida, S. Ono, Y. Sekimizu, K.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 10 Issue: 1 Pages: 49-56

    • DOI

      10.5582/ddt.2016.01022

    • NAID

      130005133322

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus2016

    • Author(s)
      Matsumoto Y, Yasukawa J, Ishii M, Hayashi Y, Miyazaki S, Sekimizu K.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 22894-22894

    • DOI

      10.1038/srep22894

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primed immune responses triggered by ingested bacteria lead to systemic infection tolerance in silkworms2015

    • Author(s)
      Miyashita, A. Takahashi, S. Ishii, K. Sekimizu, K. Kaito, C.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0130486-e0130486

    • DOI

      10.1371/journal.pone.0130486

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis2015

    • Author(s)
      Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 17092-17092

    • DOI

      10.1038/srep17092

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Use of silkworms as an experimental animal for evaluation of food and medicine Kazuhisa Sekimizu2019

    • Author(s)
      Kazuhisa Sekimizu
    • Organizer
      The 25th International Congress on Sericulture and Silk Industry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カイコの食品、医薬品の評価動物としての利用2019

    • Author(s)
      関水和久
    • Organizer
      第84回日本マイコトキシン学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] カイコ創薬から生まれた食品の機能性スクリーニングシステム2019

    • Author(s)
      関水和久
    • Organizer
      第3回 ちば新事業創出ネットワークセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] in vivo 実験的進化系を利用した細菌の病原性システムの解明2019

    • Author(s)
      垣内力
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 新規抗生物質「ライソシン」の開発2019

    • Author(s)
      関水和久、浜本洋
    • Organizer
      第2回 薬剤耐性(AMR)シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Comprehensive gene expression analysis of Cryptococcus neoformans infected in mouse brain2019

    • Author(s)
      Hiroshi Hamamoto、Sanae Ishijima、Suresh Panthee、Paudel Atmika、Kazuhisa Sekimizu
    • Organizer
      ASM Microbe 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovering novel roles of genes for virulence of Staphylococcus aureus USA300 using invertebrate model silkworm2019

    • Author(s)
      Suresh Panthee、Hiroshi Hamamoto、Atmika Paudel、Kazuhisa Sekimizu
    • Organizer
      ASM Microbe 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析2019

    • Author(s)
      浜本洋、Suresh Panhtee、石島早苗、関水和久
    • Organizer
      第40回関東医真菌懇話会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヨーグルトに利用可能な乳酸菌の抗カンジダ活性2019

    • Author(s)
      羽山和美、安部茂、関水和久
    • Organizer
      第40回 関東医真菌懇話会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 黄色ブドウ球菌の宿主感染後の時間経過に伴う網羅的遺伝子発現変化の解析2019

    • Author(s)
      浜本洋、Suresh Panthee、Atmika Paudel、関水和久
    • Organizer
      第64回 日本ブドウ球菌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cryptococcus neoformansのマウス感染状態における網羅的遺伝子発現解析2019

    • Author(s)
      浜本洋、Suresh Panthee、Atmika Paudel、石島早苗、関水和久
    • Organizer
      第63回 日本医真菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 治療効果を指向した新規感染症治療薬の同定と開発2019

    • Author(s)
      浜本洋、Suresh Panthee、石島早苗、関水和久
    • Organizer
      第42回白金シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 薬物評価系としてのカイコの利用と新規抗菌剤の開発2019

    • Author(s)
      浜本洋
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pharmacokinetics and metabolism of antibiotics in the silkworm model2018

    • Author(s)
      Hamamoto H、Horie R、Panthee S、Paudel A、Sekimizu K
    • Organizer
      ASM microbe 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic activity of antimicrobial agents is correlated with the appropriate pharmacokinetics in silkworms2018

    • Author(s)
      Paudel A、Panthee S、Urai M、Hamamoto H、Ohwada T、Sekimizu K
    • Organizer
      ASM microbe 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Silkworm model is useful for the identification of novel pathogenic genes2018

    • Author(s)
      Hamamoto H、Paudel A、Panthee S、Sekimizu K
    • Organizer
      18th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In-vivo transcriptomic analysis of Staphylococcus aureus from infected organs2018

    • Author(s)
      Panthee S、Hamamoto H、Paudel A、Sekimizu K
    • Organizer
      18th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BmPP, insect cytokine regulate broad function of innate immunity2018

    • Author(s)
      Hamamoto H
    • Organizer
      Asian Invertebrate Immunity Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of novel genes required for virulence of Staphylococcus aureus USA300 using invertebrate model silkworm2018

    • Author(s)
      Paudel A、Hamamoto H、Panthee S、Sekimizu K
    • Organizer
      Asian Invertebrate Immunity Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カイコモデルの創薬における利用2018

    • Author(s)
      浜本洋
    • Organizer
      第9回日本昆虫科学連合・日本学術会議 公開シンポジウム 「昆虫の恵みII 」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] カイコを用いた新規感染症治療薬の同定と開発2018

    • Author(s)
      浜本洋、Suresh Panthee、石島早苗、関水和久
    • Organizer
      第101回日本細菌学会関東支部総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] カイコ感染モデルでのバンコマイシン耐性黄色ブドウ球菌に対するバンコマイシンの治療効果2018

    • Author(s)
      光冨修平、浜本洋、垣内力、関水和久
    • Organizer
      第30回微生物シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] カイコ白癬菌感染モデルを用いた白癬症治療薬の評価2018

    • Author(s)
      石井雅樹、松本靖彦、山田剛、安部茂、関水和久
    • Organizer
      第38回関東医真菌懇話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 経口抗白癬薬を評価するためのカイコ感染モデルの確立2018

    • Author(s)
      松本靖彦、石井雅樹、山田剛、安部茂、関水和久
    • Organizer
      第62回日本医真菌学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析2018

    • Author(s)
      浜本洋、Suresh Panthee、石島早苗、関水和久
    • Organizer
      第62回日本医真菌学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Candida albicans TIMM1768株の酵母系、菌糸形での発現遺伝子解析2018

    • Author(s)
      石島早苗、浜本洋、山田剛、安部茂、関水和久
    • Organizer
      第62回日本医真菌学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 山椒Zanthoxylum piperitumのCandida albicans菌糸形発育抑制効果2018

    • Author(s)
      羽山和美、田口裕基、関水和久、安部茂
    • Organizer
      第62回日本医真菌学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細菌感染症研究における様々な網羅的RNA解析手法2018

    • Author(s)
      浜本洋、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 医薬品開発におけるカイコモデルの利点と実際の応用2018

    • Author(s)
      浜本洋
    • Organizer
      第2回公開シンポジウム「カイコ・シルク産業の未来~”蚕業革命”から”産業革命”へ~」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Silkworm infection model to investigate the staphylococcal virulence system2018

    • Author(s)
      垣内力
    • Organizer
      Workshop to Understand Staphylococcus aureus Pathogenesis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カイコ細菌・真菌感染モデルを用いた新規抗生物質の開発2017

    • Author(s)
      浜本洋、関水和久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 黄色ブドウ球菌の菌体表層における毒素の機能2017

    • Author(s)
      垣内力
    • Organizer
      第90回日本細菌学会総会 シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 黄色ブドウ球菌のマウス宿主内で発現上昇する遺伝子群の解析2017

    • Author(s)
      浜本洋、扇喜秀、Panthee Suresh、Paudel Atmika, 鈴木穣、関水和久
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 黄色ブドウ球菌の嫌気呼吸系発現上昇の病原性に対する寄与2017

    • Author(s)
      浜本洋、扇喜秀、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
    • Organizer
      2017年度生命科学学会合同年次大会 ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 人為的進化系を利用した細菌の病原性システムの理解2017

    • Author(s)
      垣内力
    • Organizer
      2017年度生命科学学会合同年次大会 ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] カイコモデルを利用した新規抗生物質ライソシンEの同定と開発2017

    • Author(s)
      浜本洋、関水和久
    • Organizer
      第66回日本感染症学会東日本地方会学術集会・第64回日本化学療法学会東日本支部総会合同学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] カイコ細菌感染モデルにおける治療効果を指標とした抗菌薬の合成展開法の確立2017

    • Author(s)
      浜本洋、Atmika Paudel、Suresh Panthee、浦井誠、大和田智彦、関水和久
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規抗生物質ライソシンの開発2017

    • Author(s)
      関水和久
    • Organizer
      薬剤耐性(AMR)シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] クリプトコックス感染症に対する抗真菌薬のカイコを用いた評価2017

    • Author(s)
      松本靖彦、石井雅樹、清水公徳、川本進、関水和久
    • Organizer
      真菌症フォーラム第23回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 昆虫モデルを用いて解明する細菌の病原性発動システム2016

    • Author(s)
      垣内力
    • Organizer
      第99回日本細菌学会関東支部総会 シンポジウム
    • Place of Presentation
      北里大学(東京都港区)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 病原性真菌の感染機構の解明のためのカイコ感染モデルの利用2016

    • Author(s)
      松本靖彦、石井雅樹、関水和久
    • Organizer
      第60回医真菌学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] カイコ真菌感染モデルを利用した抗真菌薬の治療効果の評価と探索2016

    • Author(s)
      浜本洋、関水和久
    • Organizer
      第60回医真菌学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] カイコ感染モデルの新規抗生物質開発における有用性2016

    • Author(s)
      関水和久
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 創薬へのカイコモデルの応用2016

    • Author(s)
      浜本洋、関水和久
    • Organizer
      昆虫デザイン研究会 家畜化過程の理解とポスト家畜化
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] An Antibacterial Agent Inhibited Bacterial Transcription by Targeting the Primary Sigma Factor and Preventing Open Complex Formation2016

    • Author(s)
      Atmika Paudel, Hiroshi Hamamoto, Kazuhisa Sekimizu
    • Organizer
      ASM Microbe
    • Place of Presentation
      Boston(MA. USA)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カイコ細菌感染モデルによって得られた新規抗生物質ライソシン Eの発見と開発2016

    • Author(s)
      浜本洋
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microbe-host interactions revealed using the silkworm infection model2016

    • Author(s)
      垣内力
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 黄色ブドウ球菌は、Isdヘム鉄取り込みシステムを介して糖尿病宿主環境に適応する2016

    • Author(s)
      松本靖彦、宮崎真也、林陽平、石井雅樹、坂上徹、垣内力、関水和久
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規抗生物質ライソシンEの同定と作用メカニズム2016

    • Author(s)
      浜本洋、関水和久
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Silkworm Model for Drug Discovery and Drug Development.2016

    • Author(s)
      Kazuhisa Sekimizu, Hiroshi Hamamoto
    • Organizer
      The 13th Asia Pacific Federation of Pharmacologist Meeting "New Paradigms in Pharmacology for Global Health"
    • Place of Presentation
      Bangkok (Thailand)
    • Year and Date
      2016-02-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification and mechanistic analysis of a novel antibiotic lysocin E2016

    • Author(s)
      Hiroshi Hamamoto, Kazuhisa Sekimizu
    • Organizer
      The 8th Japan-Korea Chemical Biology Symposium
    • Place of Presentation
      パシフィックホテル沖縄(沖縄県那覇市)
    • Year and Date
      2016-01-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Host factors enhance antimicrobial activity of “Lysocin E”2015

    • Author(s)
      Hiroshi Hamamoto, Jie Su, Keniichi Ishii, Jyunichiro Yasukawa, Atmika Paudel, Kazuhisa Sekimizu
    • Organizer
      The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification and mechanistic analysis of novel antibiotic “Lysocin E”2015

    • Author(s)
      Kazuhisa Sekimizu, Hiroshi Hamamoto
    • Organizer
      The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 宿主臓器における遺伝子発現上昇を指標とした黄色ブドウ球菌の新規病原性因子の探索2015

    • Author(s)
      扇喜秀、浜本洋、鈴木穣、関水和久
    • Organizer
      BMB2015 第38回日本分子生物学会年会、第88回日本生化学会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 黄色ブドウ球菌のGlcNAc-malを介した糖尿病宿主への病原性発揮機構2015

    • Author(s)
      石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
    • Organizer
      第9回細菌学若手コロッセウム
    • Place of Presentation
      レインボー桜島(鹿児島県鹿児島市)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高度バンコマイシン耐性黄色ブドウ球菌に対するバンコマイシンとβ-ラクタム系抗生物質の併用効果2015

    • Author(s)
      田渕史晃、松本靖彦、石井雅樹、龍野桂太、岡崎充宏、佐藤智明、森屋恭爾、関水和久
    • Organizer
      第98回日本細菌学会関東支部総会
    • Place of Presentation
      東京歯科大学(東京都千代田区)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] カイコ細菌感染モデルにて同定された新規抗生物質ライソシンE2015

    • Author(s)
      浜本洋、関水和久
    • Organizer
      第64回日本感染症学会東日本地方学術集会、第62回日本化学療法学会東日本支部総会 合同学会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 黄色ブドウ球菌のHMG-CoAレダクターゼのペプチドグリカン合成における役割2015

    • Author(s)
      松本靖彦、安川淳一郎、石井雅樹、林陽平、宮崎真也、関水和久
    • Organizer
      第60回日本ブドウ球菌研究会
    • Place of Presentation
      広島大学東京オフィス(港区芝浦)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 黄色ブドウ球菌の病原性発現に働くヌクレオシド二リン酸分解酵素に関する研究2015

    • Author(s)
      今江健太、齋藤祐樹、木崎速人、毛瀚、立野浩輝、宮下惇嗣、関水和久、垣内力
    • Organizer
      第14回次世代を担う若手ファーマ・バイオフォーラム2015
    • Place of Presentation
      千葉大学亥鼻キャンパス(千葉県千葉市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 宿主臓器における遺伝子発現上昇を指標とした黄色ブドウ球菌の新規病原性因子の探索2015

    • Author(s)
      扇喜秀、浜本洋、鈴木穣、関水和久
    • Organizer
      第14回次世代を担う若手ファーマ・バイオフォーラム2015
    • Place of Presentation
      千葉大学亥鼻キャンパス(千葉県千葉市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病宿主への感染に必要な黄色ブドウ球菌の新規病原性因子HdvA/Hbpタンパク質複合体はGlcNAc-mal脱アセチル化酵素として働く2015

    • Author(s)
      石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
    • Organizer
      第14回次世代を担う若手ファーマ・バイオフォーラム2015
    • Place of Presentation
      千葉大学亥鼻キャンパス(千葉県千葉市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] カイコの感染モデルを用いた新規感染症治療薬の発見手法2015

    • Author(s)
      関水和久
    • Organizer
      第27回微生物シンポジウム
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウス臓器に感染した黄色ブドウ球菌の網羅的遺伝子発現解析2015

    • Author(s)
      浜本洋、扇喜秀、鈴木穣、Paudel Atmika, 関水和久
    • Organizer
      第27回微生物シンポジウム
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病宿主に対する病原性因子であるHdvAタンパク質はHbpタンパク質と複合体を形成し、黄色ブドウ球菌のGlcNAc-malを脱アセチル化する2015

    • Author(s)
      石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
    • Organizer
      第27回微生物シンポジウム
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 宿主臓器に感染した黄色ブドウ球菌のRNA-Seq解析に基づく新規病原性因子の探索2015

    • Author(s)
      浜本洋
    • Organizer
      新学術領域「ゲノム支援」2015年度 拡大班会議
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
  • [Remarks] 帝京大学医真菌研究センターホームページ

    • URL

      https://www.teikyo-u.ac.jp/affiliate/laboratory/fungal_center/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 帝京大学医真菌研究センター

    • URL

      https://www.teikyo-u.ac.jp/affiliate/laboratory/fungal_center/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 微生物薬品化学教室のホームページ

    • URL

      http://www.f.u-tokyo.ac.jp/~bisei/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-06-03   Modified: 2023-10-16  

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