Previously-unappreciated roles for basophils in health and disease

• Project/Area Number: 15H05786
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Karasuyama Hajime 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (60195013)
• Project Period (FY): 2015-05-29 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥200,200,000 (Direct Cost: ¥154,000,000、Indirect Cost: ¥46,200,000); Fiscal Year 2018: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2017: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000); Fiscal Year 2016: ¥51,480,000 (Direct Cost: ¥39,600,000、Indirect Cost: ¥11,880,000); Fiscal Year 2015: ¥54,600,000 (Direct Cost: ¥42,000,000、Indirect Cost: ¥12,600,000)
• Keywords: 好塩基球 / 炎症 / アレルギー / 感染免疫 / 疾患モデル動物 / マダニ感染 / ヒスタミン / 肺気腫 / 慢性閉塞性肺疾患 / 間質マクロファファージ / アレルギー・免疫関連疾患 / 疾患動物モデル / 寄生虫感染 / マダニ / 重症熱性血小板減少症候群 / 耐性獲得 / 記憶T細胞 / IL-3 / プロテアーゼ / トロゴサイト－シス / 抗原提示 / 脱顆粒 / ノックアウトマウス / 治療標的

Outline of Final Research Achievements

Basophils were first documented 140 years ago, but their role in vivo remained enigmatic for a long time because of their paucity and the lack of basophil-deficient animals. In this study, taking advantage of newly-developed analytical tools, we have identified previously-unappreciated roles for basophils and the underlying mechanisms in the protective immunity to parasitic infections and the development of serious disorders, including chronic allergic inflammation and chronic obstructive pulmonary disease.

Academic Significance and Societal Importance of the Research Achievements

好塩基球は末梢組織常在のマスト細胞と類似性があるため、血中循環型のマスト細胞亜型であると誤解され、長い間注目されることはなかった。本研究により、好塩基球がマスト細胞とは明らかに異なる役割を担っており、アレルギーなどの病態形成に関わるとともに、本来の存在意義が寄生虫感染防御にあることが明らかとなった。これらの知見は、アレルギー疾患の新規治療法開発や寄生虫感染に対するワクチン開発に役立つものと期待される

Assessment Rating

Verification Result (Rating)

A+

Research Products

• [Int'l Joint Research] Centre de Recherche sur l'Inflammation(フランス)
• [Int'l Joint Research] Stanford University School of Medicine(米国)
• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] Stanford University(米国)
• [Int'l Joint Research] Centre de Recherche sur l'Inflammation(フランス)
• [Int'l Joint Research] Deutsches Rheuma-Forschungszentrum(ドイツ)
• [Int'l Joint Research] Stanford Univ./Harvard Univ.(米国)
• [Int'l Joint Research] University of Regensburg(ドイツ)
• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] University Hospital Regensburg(ドイツ)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Journal Article] Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice (2019)
  • Author(s): Piliponsky Adrian M.、Shubin Nicholas J.、Lahiri Asha K.、Truong Phuong、Clauson Morgan、Niino Kerri、Tsuha Avery L.、Nedospasov Sergei A.、Karasuyama Hajime、Reber Laurent L.、Tsai Mindy、Mukai Kaori、Galli Stephen J.
  • Journal Title: Nature Immunology Volume: 20 Issue: 2 Pages: 129-140
  • DOI: 10.1038/s41590-018-0288-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3?stimulated murine basophils (2019)
  • Author(s): Yoshikawa Soichiro、Oh-hora Masatsugu、Hashimoto Ryota、Nagao Toshihisa、Peters Louis、Egawa Mayumi、Ohta Takuya、Miyake Kensuke、Adachi Takahiro、Kawano Yohei、Yamanishi Yoshinori、Karasuyama Hajime
  • Journal Title: Science Signaling Volume: 12 Issue: 576
  • DOI: 10.1126/scisignal.aav2060
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Amphiregulin from basophils amplifies basophil-mediated chronic skin inflammation (2019)
  • Author(s): Hashimoto Takashi、Satoh Takahiro、Karasuyama Hajime、Yokozeki Hiroo
  • Journal Title: Journal of Investigative Dermatology Volume: - Issue: 8 Pages: 1834-837
  • DOI: 10.1016/j.jid.2019.02.023
  • Peer Reviewed
• [Journal Article] Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice (2018)
  • Author(s): Tabakawa Yuya、Ohta Takuya、Yoshikawa Soichiro、Robinson Elisabeth J.、Yamaji Kayoko、Ishiwata Kenji、Kawano Yohei、Miyake Kensuke、Yamanishi Yoshinori、Ohtsu Hiroshi、Adachi Takahiro、Watanabe Naohiro、Kanuka Hirotaka、Karasuyama Hajime
  • Journal Title: Frontiers in Immunology Volume: 9
  • DOI: 10.3389/fimmu.2018.01540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] How do basophils contribute to Th2 cell differentiation and allergic responses? (2018)
  • Author(s): Karasuyama Hajime、Miyake Kensuke、Yoshikawa Soichiro、Kawano Yohei、Yamanishi Yoshinori
  • Journal Title: International Immunology Volume: 30 Issue: 9 Pages: 391-396
  • DOI: 10.1093/intimm/dxy026
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice (2018)
  • Author(s): Nagao Toshihisa、Yamanishi Yoshinori、Miyake Kensuke、Teranishi Mio、Takahashi Saori、Yoshikawa Soichiro、Kawano Yohei、Karasuyama Hajime
  • Journal Title: International Immunology Volume: 31 Issue: 1 Pages: 41-49
  • DOI: 10.1093/intimm/dxy062
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Basophils trigger emphysema development in a murine model of COPD through IL-4?mediated generation of MMP-12?producing macrophages (2018)
  • Author(s): Shibata Sho、Miyake Kensuke、Tateishi Tomoya、Yoshikawa Soichiro、Yamanishi Yoshinori、Miyazaki Yasunari、Inase Naohiko、Karasuyama Hajime
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 51 Pages: 13057-13062
  • DOI: 10.1073/pnas.1813927115
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Crucial Role for Basophils in Acquired Protective Immunity to Tick Infestation (2018)
  • Author(s): Karasuyama Hajime、Tabakawa Yuya、Ohta Takuya、Wada Takeshi、Yoshikawa Soichiro
  • Journal Title: Frontiers in Physiology Volume: 9
  • DOI: 10.3389/fphys.2018.01769
  • Peer Reviewed / Open Access
• [Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model. (2018)
  • Author(s): Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
  • Journal Title: Biochem Biophys Res Commun. Volume: 496 Issue: 2 Pages: 367-373
  • DOI: 10.1016/j.bbrc.2018.01.053
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs (2018)
  • Author(s): Pellefigues Christophe、Dema Barbara、Lamri Yasmine、Saidoune Fanny、Chavarot Nathalie、Loheac Charlotte、Pacreau Emeline、Dussiot Michael、Bidault Caroline、Marquet Florian、Jablonski Mathieu、Chemouny Jonathan M.、Jouan Fanny、Dossier Antoine、Chauveheid Marie-Paule, Karasuyama Hajime、Daugas Eric、Charles Nicolas
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 725-725
  • DOI: 10.1038/s41467-018-03129-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors (2018)
  • Author(s): Kawano Yohei、Petkau Georg、Stehle Christina、Durek Pawel、Heinz Gitta Anne、Tanimoto Kousuke、Karasuyama Hajime、Mashreghi Mir-Farzin、Romagnani Chiara、Melchers Fritz
  • Journal Title: Blood Volume: 131 Issue: 18 Pages: 2026-2035
  • DOI: 10.1182/blood-2017-09-805259
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multifaceted roles of basophils in health and disease (2017)
  • Author(s): Karasuyama H, Miyake K, Yoshikawa S, Yamanishi Y
  • Journal Title: J Allergy Clin Immunol Volume: S0091-6749 Issue: 2 Pages: 31894-31898
  • DOI: 10.1016/j.jaci.2017.10.042
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in the importance of mast cells, basophils, IgE and IgG, versus CD4+ T cells and ILC2 cells, in primary and secondary immunity to Strongyloides venezuelensis (2017)
  • Author(s): Mukai K, Karasuyama H, Kabashima K, Kubo M, Galli SJ
  • Journal Title: Infect Immun Volume: - Issue: 5
  • DOI: 10.1128/iai.00053-17
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Human eosinophils constitutively express a unique serine protease, PRSS33 (2017)
  • Author(s): Toyama S, Okada N, Matsuda A, Morita H, Saito H, Fujisawa T, Nakae S, Karasuyama H, Matsumoto K.
  • Journal Title: Allergology International Volume: 66 Issue: 3 Pages: 463-471
  • DOI: 10.1016/j.alit.2017.01.001
  • NAID: 130005858869
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Emerging roles of basophils in allergic inflammation (2017)
  • Author(s): Kensuke Miyake, Hajime Karasuyama
  • Journal Title: Allergology International Volume: 66 Issue: 3 Pages: 382-391
  • DOI: 10.1016/j.alit.2017.04.007
  • NAID: 130005858829
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Recent advances in understanding basophil-mediated Th2 immune responses (2017)
  • Author(s): Yamanishi Yoshinori、Miyake Kensuke、Iki Misako、Tsutsui Hidemitsu、Karasuyama Hajime
  • Journal Title: Immunological Reviews Volume: 278 Issue: 1 Pages: 237-245
  • DOI: 10.1111/imr.12548
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Basophils contribute to pristane-induced Lupus-like nephritis model (2017)
  • Author(s): Dema Barbara、Lamri Yasmine、Pellefigues Christophe、Pacreau Emeline、Saidoune Fanny、Bidault Caroline、Karasuyama Hajime、Sacre Karim、Daugas Eric、Charles Nicolas
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 7969-7969
  • DOI: 10.1038/s41598-017-08516-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Skin CD4+ Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites (2017)
  • Author(s): Ohta Takuya、Yoshikawa Soichiro、Tabakawa Yuya、Yamaji Kayoko、Ishiwata Kenji、Shitara Hiroshi、Taya Choji、Oh-hora Masatsugu、Kawano Yohei、Miyake Kensuke、Yamanishi Yoshinori、Yonekawa Hiromichi、Watanabe Naohiro、Kanuka Hirotaka、Karasuyama Hajime
  • Journal Title: Frontiers in Immunology Volume: 8 Pages: 1348-1348
  • DOI: 10.3389/fimmu.2017.01348
  • Peer Reviewed / Open Access
• [Journal Article] Basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with microvascular hyperpermeability and leukocyte infiltration. (2017)
  • Author(s): Tsutsui, H., Yamanishi, Y., Ohtsuka, H., Sato, S., Yoshikawa, S., and Karasuyama, H.
  • Journal Title: J. Biol. Chem. Volume: 292 Issue: 3 Pages: 1061-1067
  • DOI: 10.1074/jbc.m116.754648
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils (2017)
  • Author(s): Miyake, K., Shiozawa, N., Nagao, T., Yoshikawa, S., Yamanishi, Y., and Karasuyama, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 114 Issue: 5 Pages: 1111-1116
  • DOI: 10.1073/pnas.1615973114
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis (2017)
  • Author(s): Balbino, B., Sibilano, R., Starkl, P., Marichal, T., Gaudenzio, N., Karasuyama, H., Bruhns, P., Tsai, M., Reber, L.L., and Galli, S.J.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 139 Issue: 2 Pages: 584-596
  • DOI: 10.1016/j.jaci.2016.05.047
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils (2017)
  • Author(s): Bando, T., Fujita, S., Nagano, N., Hayashi, A., Yoshikawa, S., Yamanishi, Y., Minami, M., Tada, H., Kishikawa, K., and Karasuyama, H.
  • Journal Title: Biochem Biophys Rep. Volume: 10 Pages: 82-87
  • DOI: 10.1016/j.bbrep.2017.03.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. (2016)
  • Author(s): Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N
  • Journal Title: Blood Volume: 印刷中 Issue: 21 Pages: 2607-17
  • DOI: 10.1182/blood-2015-10-673087
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Basophils trigger fibroblast activation in cardiac allograft fibrosis development. (2016)
  • Author(s): Schiechl G, Hermann FJ, Rodriguez Gomez M, Kutzi S, Schmidbauer K, Talke Y, Neumayer S, Goebel N, Renner K, Bruhl H, Karasuyama H, Obata-Ninomiya K, Utpatel K, Evert M, Hirt SW, Geissler EK, Fichtner-Feigl S, Mack M.
  • Journal Title: American Journal of Transplandation Volume: 印刷中 Issue: 9 Pages: 2574-2588
  • DOI: 10.1111/ajt.13764
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Basophils and mast cells in immunity and inflammation. (2016)
  • Author(s): Yamanishi, Y., and Karasuyama, H.
  • Journal Title: Semin. Immunopathol. Volume: 38 Issue: 5 Pages: 535-537
  • DOI: 10.1007/s00281-016-0582-0
  • Peer Reviewed / Open Access
• [Journal Article] Basophil-derived IL-4 plays versatile roles in immunity (2016)
  • Author(s): Yamanishi, Y., and Karasuyama, H.
  • Journal Title: Semin. Immunopathol. Volume: 38 Issue: 5 Pages: 615-622
  • DOI: 10.1007/s00281-016-0568-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Real-time imaging of mast cell degranulation in vitro and in vivo (2016)
  • Author(s): Horiguchi, K., Yoshikawa, S., Saito, A., Haddad, S., Ohta, T., Miyake, K., Yamanishi, Y., and Karasuyama, H.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 479 Issue: 3 Pages: 517-522
  • DOI: 10.1016/j.bbrc.2016.09.100
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Allergic skin sensitization promotes eosinophilic esophagitis via the interleukin-33-basophil axis (2016)
  • Author(s): Venturelli, N., Lexmond, W.S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger E., and Oyoshi, M.K.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 138 Issue: 5 Pages: 1367-1380
  • DOI: 10.1016/j.jaci.2016.02.034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R (2016)
  • Author(s): Kojima, T., Tsuchiya, K., Ikemizu, S., Yoshikawa, S., Yamanishi, Y., Watanabe, M., and Karasuyama, H.
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 36457-36457
  • DOI: 10.1038/srep36457
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice (2016)
  • Author(s): Iki, M., Tanaka, K., Deki, H., Fujimaki, M., Sato, S., Yoshikawa, S., Yamanishi, Y., and Karasuyama, H.
  • Journal Title: Blood Volume: 128 Issue: 25 Pages: 2909-2918
  • DOI: 10.1182/blood-2016-07-729392
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice (2016)
  • Author(s): Baba, T., Tanabe, Y., Yoshikawa, S., Yamanishi, Y., Morishita, S., Komatsu, N., Karasuyama, H., Hirano, A., and Mukaida, N.
  • Journal Title: Blood Volume: 未定
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Allergic skin sensitization promotes eosinophilic esophagitis via the interleukin-33-basophil axis. (2016)
  • Author(s): Venturelli, N., Lexmond, W.S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger E., and Oyoshi, M.K.
  • Journal Title: J. Allergy Clin. Immunol. Volume: 未定
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. (2015)
  • Author(s): Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
  • Journal Title: Immunity Volume: 43 Issue: 1 Pages: 175-86
  • DOI: 10.1016/j.immuni.2015.06.021
  • NAID: 40020962854
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens (2015)
  • Author(s): LiHua Li, Takuya Ohta, Kayo Horiguchi, Yohei Kawano, Hiroshi Ohtsu, Yoshinori Yamanishi, MD., Hajime Karasuyama.
  • Journal Title: Biochem Biophys Res Commun Volume: 467 Issue: 1 Pages: 70-75
  • DOI: 10.1016/j.bbrc.2015.09.120
  • Peer Reviewed
• [Presentation] これまで見逃されていた好塩基球の存在意義と病態形成における役割 ～山椒は小粒でもぴりりと辛い～ (2019)
  • Author(s): 烏山 一
  • Organizer: 第２８回東京免疫フォーラム
  • Invited
• [Presentation] 好塩基球の存在意義とアレルギー病態形成における役割 (2018)
  • Author(s): 烏山 一.
  • Organizer: 第 67 回日本アレルギー学会学術集会
  • Invited
• [Presentation] 慢性閉塞性肺疾患(COPD)の病態に好塩基球が重要な役割を果 たしている (2018)
  • Author(s): 柴田 翔、立石 知也、烏山 一、宮崎 泰成
  • Organizer: 第 92 回閉塞性肺疾患研究会
• [Presentation] Roles for basophils in Th2 immune responses (2018)
  • Author(s): Hajime Karasuyama
  • Organizer: The 10th Japanese-German Immunology Workshop
  • Int'l Joint Research
• [Presentation] Roles for basophils in Th2 immune responses (2018)
  • Author(s): Hajime Karasuyama
  • Organizer: The 32nd CIA
  • Int'l Joint Research
• [Presentation] Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance (2018)
  • Author(s): Kensuke Miyake, Ayako Fukui, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Histamine Released From Skin-Infiltrating Basophils but not mast cells is crucial for acquired tick resistance in mice (2018)
  • Author(s): Soichiro Yoshikawa, Yuya Tabakawa, Takuya Ohta, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Yoshi- nori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Kara- suyama.
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice (2018)
  • Author(s): Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama
  • Organizer: The 47th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Basophils in immune-related disease (2017)
  • Author(s): Karasuyama, H.
  • Organizer: Third International Symposium on IgG4-RD and Fibrosis
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2017-02-16
  • Int'l Joint Research / Invited
• [Presentation] COPDの病態における炎症性単球、間質マクロファージの役割 (2017)
  • Author(s): 柴田 翔, 立石 知也, 吉川 宗一郎, 山西 吉典, 稲瀬 直彦, 烏山 一
  • Organizer: 第66回日本アレルギー学会
• [Presentation] Basophil tryptase mMCP-11 plays a crucial role in the IgE-mediated chronic allergic inflammation (2017)
  • Author(s): Yoshinori Yamanishi, Misako Iki, Kensei Tanaka, Hayato Deki, Mio Fujimaki, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama
  • Organizer: 第66回日本アレルギー学会
• [Presentation] Prolonged Ca2+ influx via STIM2 is essential for cytokine-induced IL-4 production in basophil (2017)
  • Author(s): Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP12 production in a mouse model of COPD (2017)
  • Author(s): Sho Shibata, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation (2017)
  • Author(s): Yoshinori Yamanishi, Misako Iki, Kensei Tanaka, Hayato Deki, Mio Fujimaki, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Shingo Sato, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC clas II complexes from dendritic cells (DCs) (2017)
  • Author(s): Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] The basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with microvascular hyperpermeability and leukocyte infiltration (2017)
  • Author(s): Hidemitsu Tsutsui, Yoshinori Yamanishi, Hiromi Ohtsuka, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Histamine plays a critical role in acquired protective immunity against tick infestation (2017)
  • Author(s): Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Yoshinori Yamanishi, Naohiro Watanabe, Hiroshi Ohtsu, Hirotaka Kanuka, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Skin-resident memory CD4+ T cells play an essential role in acquired tick resistance through IL-3-mediated basophil recruitment (2017)
  • Author(s): Takuya Ohta, Soichiro Yoshikawa, Kayoko Yamaji, Kenji Ishiwata, Yuya Tabakawa, Yohei Kawano, Yoshinori Yamanishi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated allergic inflammation (2017)
  • Author(s): Toshihisa Nagao, Mio Teranishi, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils (2017)
  • Author(s): Tomoyuki Bando, Setsuko Fujita, Naoko Nagano, Soichiro Yoshikawa, Yoshinori Yamanishi, Masashi Minami, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Novel CD200 hologues iSEC1 and I SEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R (2017)
  • Author(s): Toshiyuki Kojima, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Emerging roles of basophils in allergic inflammation and immune regulation (2017)
  • Author(s): Hajime Karasuyama
  • Organizer: The 46th Annual Meeting of The Japanese Society for Immunology
• [Presentation] これまで見逃されていた好塩基球の存在意義と病態形成における役割 (2017)
  • Author(s): 烏山 一
  • Organizer: 第45回日本臨床免疫学会
  • Invited
• [Presentation] Emerging roles of basophils in allergy and immunity (2016)
  • Author(s): Karasuyama, H.
  • Organizer: 41th JSID Annual Meeting
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2016-12-09
  • Invited
• [Presentation] Basophils gain the capacity of antigen presentation by acquiring MHC class II molecules from dendritic cells through trogocytosis (2016)
  • Author(s): Miyake, K., Shiozawa, N., Nagao, T., Kawawa, M., Yoshikawa, S., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 45th Annual Meeting of the JSI
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-12-05
• [Presentation] Basophil-selective mMCP-11 plays crucial roles in the development of IgE-mediated chronic allergic inflammation in the skin (2016)
  • Author(s): Iki, M., Tanaka, K., Deki, H., Nagao, T, Horibe, M., Sato, S., Yoshikawa, S., Yamanishi Y., Karasuyama, H.
  • Organizer: The 45th Annual Meeting of the JSI
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-12-05
• [Presentation] STIM2 plays an essential role in IL-4 production by IL-33-stimulated basophils (2016)
  • Author(s): Yoshikawa, S, Oh-hora, M., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 45th Annual Meeting of the JSI
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-12-05
• [Presentation] Emerging roles of basophils in acquired protective immunity to tick infestation (2016)
  • Author(s): Karasuyama, H.
  • Organizer: XXV International Congress of Entomology
  • Place of Presentation: Orland, USA
  • Year and Date: 2016-09-29
  • Int'l Joint Research / Invited
• [Presentation] mMCP-8, a basophil specific protease, triggers an inflammatory response by stimulating fibroblasts to produce chemokines (2016)
  • Author(s): Tsutsui, H., Yamanishi, Y., Yoshikawa, S., Sato, S., Karasuyama, H.
  • Organizer: The 16th International Congress of Immunology
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] STIM1/2 plays essential roles in basophil activation and development of IgE-mediated chronic allergic inflammation (2016)
  • Author(s): Yoshikawa, S, Oh-hora, M., Adachi, T., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 16th International Congress of Immunology
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-08-21
• [Presentation] Sugar modification of carrier protein in allergen determines the magnitude of IgE- and basophil-mediated allergic inflammation (2016)
  • Author(s): Nagao, T., Takahashi, S., Kawawa, M., Miyake, K., Yoshikawa, S., Yamanishi, Y., Karasuyama, H.
  • Organizer: The 16th International Congress of Immunology
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2016-08-21
• [Presentation] Emerging roles of basophils and IgE in allergy and immunity (2016)
  • Author(s): Karasuyama, H.
  • Organizer: FASEB Conference “IgE and Allergy”
  • Place of Presentation: West Palm Beach, USA
  • Year and Date: 2016-07-26
  • Int'l Joint Research / Invited
• [Presentation] Basophil-specific protease mMCP-8 triggers skin inflammation through activation of dermal fibroblasts (2015)
  • Author(s): Tsutsui H, Yamanishi Y, Tatebayashi S, Yoshikawa S, Sato S, Karasuyama H.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-11-18
• [Presentation] Basophils acquire MHC class II molecules from DCs and exert antigen presenting capacity (2015)
  • Author(s): Miyake K, Shiozawa N, Nagao T, Yahagi Y, Yoshikawa S, Yamanishi Y, Karasuyama H.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-11-18
• [Presentation] Molecular properties of carrier protein in allergen are critical for the development of IgE-mediated chronic allergic inflammation in the skin (2015)
  • Author(s): Nagao T, Takahashi S, Kawawa M, Miyake K, Yoshikawa S, Sato S, Yamanishi Y, Karasuyama H.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-11-18
• [Presentation] Emerging roles of basophils in acquired protective immunity to parasitic infections (2015)
  • Author(s): Karasuyama, H.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-11-18
• [Presentation] Basophils have immerged as a key player in immunity (2015)
  • Author(s): Karasuyama, H.
  • Organizer: 14th International Workshop on Langerhan
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-11-07
  • Invited
• [Presentation] Basophil: A Key Player in Immunity and Inflammation (2015)
  • Author(s): Karasuyama, H.
  • Organizer: XXIV World Allergy Congress (WAC 2015)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-10-17
  • Invited
• [Presentation] 外部ならびに内部寄生虫感染防御における好塩基球の重要性 (2015)
  • Author(s): 烏山 一
  • Organizer: 第158 回日本獣医学会学術集会
  • Place of Presentation: 北里大学獣医学部十和田キャンパス（十和田）
  • Year and Date: 2015-09-07
  • Invited
• [Remarks] 免疫アレルギー学分野
  • URL: https://immune-regulation.org
• [Remarks] 免疫アレルギー分野
  • URL: https://immune-regulation.org
• [Remarks] 東京医科歯科大学・大学院医歯学総合研究科・免疫アレルギー分野
  • URL: http://immune-regulation.org
• [Remarks] プレス報道 「 希少細胞である好塩基球によるアレルギー誘導の謎が解けた! 」
  • URL: http://www.tmd.ac.jp/archive-tmdu/kouhou/20170117.pdf
• [Remarks] プレス報道 「 アレルギー炎症を引き起こす新たな鍵分子を発見 」
  • URL: http://www.tmd.ac.jp/archive-tmdu/kouhou/20161028.pdf
• [Remarks] 免疫アレルギー学分野
  • URL: http://immune-regulation.org