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Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders

Research Project

Project/Area Number 15H05787
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

谷口 維紹  東京大学, 先端科学技術研究センター, 客員研究員 (50133616)

Co-Investigator(Kenkyū-buntansha) 岩倉 洋一郎  東京理科大学, 研究推進機構生命医科学研究所, 教授 (10089120)
西尾 純子  東京大学, 生産技術研究所, 特任助教 (40598679)
藤尾 圭志  東京大学, 医学部附属病院, 教授 (70401114)
柳井 秀元  東京大学, 生産技術研究所, 特任准教授 (70431765)
根岸 英雄  東京大学, 生産技術研究所, 特任助教 (60514297)
山本 一彦  東京大学, 医学部附属病院, 教授 (80191394)
生島 弘彬  東京大学, 生産技術研究所, 特任助教 (80719154)
Project Period (FY) 2015-05-29 – 2020-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥171,990,000 (Direct Cost: ¥132,300,000、Indirect Cost: ¥39,690,000)
Fiscal Year 2019: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2018: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2017: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
Fiscal Year 2016: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2015: ¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Keywords免疫シグナル伝達 / DAMP / 自然免疫受容体 / HMGB1 / 炎症・がん / 恒常性維持 / 自然免疫 / 炎症 / がん / 自己免疫疾患 / 免疫原性核酸
Outline of Annual Research Achievements

本研究は、自然免疫系を基軸とした生体の恒常性維持機構の解明と、その破綻がもたらす疾患の治療基盤の確立を目的としている。
HMGB1(High-mobility group box 1)について、in vitroで好中球がHMGB1に対する遊走能を示す知見を得、HMGB1は好中球遊走を介して炎症を促進していると考えられた。さらに、HMGB1の90番目のリシンがアセチル化を受けることを見出し、このリシン残基をアルギニンに置換したHMGB1変異体ノックインマウス(リシンのアセチル化が行えずHMGB1が細胞外に放出されない)を作製した。死細胞から放出されるDAMPsの探索を行い、免疫抑制性の新規DAMPs、PGE2(prostaglandin E2)を同定した。PGE2が、過剰な炎症を抑え臓器障害を抑制すること、また抗腫瘍応答を弱めることを明らかにした*。
IMF002(免疫抑制性化合物)の標的として低分子核内RNA(snRNA)を同定した。本snRNAがマウスやヒトのRAやSLEの血清中で有意に増加することを見出した。遺伝子欠損マウス、トランスジェニックマウスの作出に成功している。また、IMF003が抗腫瘍作用を示すことを発見し、その機構としてSTINGに依存的なシグナル経路の活性化によりI型IFN応答を誘導するという知見を得た。
胆嚢由来SP-Dが腸内細菌叢、及び腸管組織の恒常性維持に寄与していることを示した。一方で、腸炎罹患時には肝グルココルチコイド産生を介して胆嚢SP-D産生が亢進することを見出し、肝-胆-腸内細菌を基軸としたSP-Dを介する調節機構の存在を明らかにした*。
複数のC型レクチン受容体について、がん細胞排除機構への関与を検討した結果、Dectin-2が肝クッパー細胞を介して転移性肝がん細胞の排除に寄与していることを明らかにした*。(*は論文発表を行った)。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

炎症と密接に関連する好中球の遊走にHMGB1が重要であることを突き止めた。それによりHMGB1による炎症促進機構の一つが同定されたと考えられる。また、HMGB1を標的とするデコイ核酸ISM ODNが、種々の炎症モデルで病態を抑制する機構にも、好中球集積の低下が関与するという知見を得た。すなわち、DAMPsとして知られているHMGB1の機能の一端を明らかにできた。
また、新規DAMPsの同定についても成功しており、免疫抑制性DAMPとしてPGE2を同定した。臓器障害やがんの増大に重要であることを明らかにし、一連の結果を論文として発表している。またさらに、死細胞から放出される新規炎症性DAMPを同定し、その機能解析を進めており、予定以上の成果が出ている。
IMF002の標的であるsnRNAがマウス、ヒトにおけるSLE、関節リウマチの血清中で有意に増加することを見出し、IMF002がこれらの疾患モデルで病態を抑制することを突き止めている。snRNAのトランスジェニックマウス及びコンディショナル欠損マウスを作成し、このsnRNAの炎症誘導の分子機構を解析しており、これらの病態発症、増悪のメカニズムの一端が明らかにできるものと期待される。
腸管恒常性の維持においては、胆嚢由来SP-Dが腸管内で細菌叢を制御することにより消化管の恒常性が維持されていること証明し、今年度論文発表した。
また、C型レクチン受容体についてがん細胞排除への関与については、予定通りDectin-2、Mincle、Mclを検討し、Kupffer細胞に特異的に発現するDectin-2を介して肝転移がん細胞を貪食し排除するという機構を新たに見出し論文として公表した。
このように、新知見が多数得られている状況であり、本研究課題の予定期間内において、さらに発展が見込める状況である。よって、上記のように判断した。

Strategy for Future Research Activity

今後の研究の推進方策について、基本的には申請時の研究計画に沿って推進する。新展開が見られた際、または技術的困難が生じた場合には、代替法の検討などにより、適宜解決し、研究を推進していく予定である。これまでのところでは検討を進める上で大きな支障は生じていない。
HMGB1と炎症との関わりについては、HMGB1による好中球の遊走促進の病態モデルにおける重要性について検討していく。HMGB1の機能を阻害するISM ODNについても、病態の抑制と好中球の遊走との関連について検討を進めていく予定である。炎症促進性の新規DAMPsについて、その機能解析を進めており、ノックアウトマウスの作成を進めていく予定である。
ncRNAについてはノックアウトマウス、トランスジェニックマウスの作成が完了したことから、マウス個体を用いて、病態モデルにおけるncRNAの役割について検討を進める。胆嚢由来SP-Dが腸管内で細菌叢を制御することにより消化管の恒常性が維持されていることがわかった。本研究から派生した課題として、胆嚢由来の他の抗菌分子の解析、SP-D欠損によってもたらされるdysbiosisがどのような機構で腸管組織恒常性の破綻を来たすかについての解析、などを検討していきたい。Dectin-1キメラマウスについても、免疫監視、恒常性維持との関連について、検討を進めていく予定である。
一連の検討を通して、免疫系による恒常性維持システムの解明とその制御法の開発により、疾患の治療基盤の確立を目指していく。

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(7 results)
  • 2018 Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report

Research Products

(178 results)

All 2018 2017 2016 2015 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.2018

    • Author(s)
      Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S,Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
    • Journal Title

      Sci. Rep.

      Volume: 8 Pages: 2021-2021

    • DOI
      10.1038/s41598-018-19769-1
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.2018

    • Author(s)
      Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
    • Journal Title

      Cancer Res.

      Volume: -

    • DOI
      10.1158/0008-5472.can-17-2761
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.2018

    • Author(s)
      Yoshida, K., Murayama, M., Shimizu, K., Tang, C., Katagiri, N., Matsuo, K., Fukai F., and Iwakura, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 496 Pages: 934-940

    • DOI
      10.1016/j.bbrc.2018.01.116
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NK cells control tumor-promoting function of neutrophils in mice.2018

    • Author(s)
      Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
    • Journal Title

      Cancer Immunology Research

      Volume: 印刷中 Pages: 348-357

    • DOI
      10.1158/2326-6066.cir-17-0204
    • NAID
      120006402039
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.2018

    • Author(s)
      Kochi Y, Kamatani Y, Kondo Y, Suzuki A, Kawakami E, Hiwa R, Momozawa Y, Fujimoto M, Jinnin M, Tanaka Y, Kanda T, Cooper RG, Chinoy H, Rothwell S, Lamb JA, Vencovský J, Mann H,・・・・, Amano H(計48名33番目), et. al.
    • Journal Title

      Ann Rheum Dis.

      Volume: 77 Pages: 602-611

    • DOI
      10.1136/annrheumdis-2017-212149
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family.2017

    • Author(s)
      Negishi, H., Taniguchi, T., Yanai, H.
    • Journal Title

      Cold Spring Harb Perspect Biol.

      Volume: -

    • DOI
      10.1101/cshperspect.a028423
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fine-tuning type I IFN signaling: A new chapter in the IFN saga.2017

    • Author(s)
      Yanai, H., Taniguchi, T.
    • Journal Title

      Cell Res.

      Volume: 27 Pages: 1407-1408

    • DOI
      10.1038/cr.2017.118
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.2017

    • Author(s)
      Sarashina-Kida H、Negishi H、Nishio J、Suda W、Nakajima Y、Yasui-Kato M、Iwaisako K、Kang S、Endo N、Yanai H、Asagiri M、Kida H、Hattori M、Kumanogoh A、Taniguchi T
    • Journal Title

      Proc Natl Acad Sci U. S. A.

      Volume: 114 Pages: 10178-10183

    • DOI
      10.1073/pnas.1712837114
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus2017

    • Author(s)
      Tsuge M, Uchida T, Hiraga N, Kan H, Makokha GN, Abe-Chayama H, Miki D, Imamura M, Ochi H, Hayes CN, Shimozono R, Iwamura T, Narumi H, Suzuki T, Kainoh M, Taniguchi T, Chayama K.
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 印刷中 Pages: 61-61

    • DOI
      10.1128/aac.00183-17
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel pegylated IFN-β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer.2017

    • Author(s)
      Iwamura T., Narumi H., Suzuki T., Yanai H., Mori K., Yamashita K., Tsushima Y., Asano T., Izawa A., Momen S., Nishimura K., Tsuchiyama H., Uchida M., Yamashita Y., Okano K., Taniguchi T.
    • Journal Title

      Cancer Science

      Volume: - Pages: 581-589

    • DOI
      10.1111/cas.13176
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Brain interleukin-1 facilitates learning of a water maze spatial memory task in young mice.2017

    • Author(s)
      Takemiya T, Fumizawa K, Yamagata K, Iwakura Y, Kawakami M.
    • Journal Title

      Front Behav Neurosci.

      Volume: 11 Pages: 202-202

    • DOI
      10.3389/fnbeh.2017.00202
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae.2017

    • Author(s)
      Lamprinaki, D., Beasy, G., Zhekova, A., Wittmann, A., James, S., Dicks, J., Iwakura, Y., Saijo, S., Wang, X., Chow, C. W., Roberts, I., Korcsmaros, T., Mayer, U., Wileman, T., and Kawasaki, N.
    • Journal Title

      Front Immunol.

      Volume: 8 Pages: 1397-1397

    • DOI
      10.3389/fimmu.2017.01397
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Production of low-molecular weight soluble yeast β-glucans by an acid degradation method.2017

    • Author(s)
      Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
    • Journal Title

      Int. J. Biol. Macromol.

      Volume: 107 Pages: 2269-2278

    • DOI
      10.1038/mi.2017.86
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.2017

    • Author(s)
      Chenuet, P., Fauconnier, L., Madouri. F., Marchiol, T., Rouxel, N., Ledru, A., Mauny, P., Lory, R., Uttenhove, C., van Snick. J., Iwakura, Y., di Padova, F., Quesniaux, V., Togbe, D., and Ryffel, B.
    • Journal Title

      Clin. Sci. (Lond)

      Volume: 131 Pages: 2533-2548

    • DOI
      10.1042/cs20171034
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis.2017

    • Author(s)
      Deloer, S. Nakamura, R. Kikuchi, M. Moriyasu, T. Kalenda, Y. D. J. Mohammed, E. S. Senba, M. Iwakura, Y. Yoshida, H. Hamano, S.
    • Journal Title

      Parasitology International

      Volume: 66 Pages: 817-823

    • DOI
      10.1016/j.parint.2017.09.011
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-17A-deficient mice are highly susceptible to Toxoplasma gondii infection due to excessively induced T. gondii HSP70 and IFN-γ production.2017

    • Author(s)
      Moroda M, Takamoto M, Iwakura Y, Nakayama J, Aosai F
    • Journal Title

      Infect. Immun.

      Volume: 85 Pages: 00399-17

    • DOI
      10.1128/iai.00399-17
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.2017

    • Author(s)
      Wang, J., Ge, P., Qiang, L., Tian, F., Zhao, D., Chai, Q., Zhu, M., Zhou, R., Meng, G., Iwakura, Y., Gao, G. F., and Liu, C. H.
    • Journal Title

      Nat. Commun.

      Volume: 8 Pages: 244-244

    • DOI
      10.4049/jimmunol.1700655
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.2017

    • Author(s)
      Brown, B. R., Lee, E. J., Snow, P. E., Vance, E. E., Iwakura, Y., Ohno, N., Miura, N., Lin, X., Brown, G. D., Wells, C. A., Smith, J. R., Caspi, R. R., and Rosenzweig, H. L.
    • Journal Title

      Clin. Exp. Immunol.

      Volume: 190 Pages: 293-303

    • DOI
      10.1111/cei.13021
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An ocular commensal protects from corneal infection by driving an IL-17 response from mucosal γδT cells.2017

    • Author(s)
      St Leger, A. J., Desal, J. V., Drummond, R. A., Kugadas, A., Almaghrabi, F., Silver, P., Raychaudhuri, K., Gadjeva, M., Iwakura, Y., Lionakis, M., and Caspi, R. R.
    • Journal Title

      Immunity

      Volume: 47 Pages: 148-158

    • DOI
      10.1016/j.immuni.2017.06.014
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nociceptors Boost the Resolution of Fungal Osteo-inflammation via the TRP channel-CGRP-Jdp2 axis2017

    • Author(s)
      Maruyama Kenta、Takayama Yasunori、Kondo Takeshi、Ishibashi Ken-ichi、Sahoo Bikash Ranjan、Kanemaru Hisashi、Kumagai Yutaro、Martino Mika?l M.、Tanaka Hiroki、Ohno Naohito、Iwakura Yoichiro、Takemura Naoki、Tominaga Makoto、Akira Shizuo
    • Journal Title

      Cell Rep.

      Volume: 19 Pages: 2730-2742

    • DOI
      10.1016/j.celrep.2017.06.002
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein tyrosine phosphatase δ mediates the Sema3A-induced cortical basal dendritic arborization through the activation of Fyn tyrosine kinase.2017

    • Author(s)
      Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM.
    • Journal Title

      J. Neurosci.

      Volume: 37 Pages: 7125-7139

    • DOI
      10.1523/jneurosci.2519-16.2017
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.2017

    • Author(s)
      Giles, D. A., et.al.
    • Journal Title

      Nat. Med.

      Volume: 23 Pages: 829-838

    • DOI
      10.1038/nm.4346
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method.2017

    • Author(s)
      Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Okita, K., Iwakura, Y., and Ohno, N.
    • Journal Title

      Int. J. Biol. Macromol.

      Volume: 104 Pages: 367-376

    • DOI
      10.1016/j.ijbiomac.2017.06.036
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.2017

    • Author(s)
      Zhang, C., Feng, J., Du, J., Zhuo, Z., Yang, S., Zhang, W., Wang, W., Zhang, S., Iwakura, Y., Meng, G., Fu, Y. X., Hou, B., and Tang, H.
    • Journal Title

      Cell. Mol. Immunol.

      Volume: -

    • DOI
      10.1038/cmi.2017.22
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity2017

    • Author(s)
      Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
    • Journal Title

      Cell Death Differ.

      Volume: in press Pages: 1079-1090

    • DOI
      10.1038/cdd.2017.56
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Megakaryocytes compensate for Kit insufficiency in murine arthritis.2017

    • Author(s)
      Cunin, P., Penke, L. R., Thon, J. N., Monach, P. A., Jones, T., Chang, M. H., Chen, M. M., Melki, I., Lacroix, S., Iwakura, Y., Ware, J., Gurish, M. F., Italiano, J. E., Boilard, E., and Nigrovic, P. A.
    • Journal Title

      J. Clin. Invest.

      Volume: 27 Pages: 1714-1724

    • DOI
      10.1172/jci84598
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis.2017

    • Author(s)
      Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike T, Nakamura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 46322-46322

    • DOI
      10.1038/srep46322
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dectin-2 deficiency modulates Th1 differentiation and improves wound healing after myocardial infarction.2017

    • Author(s)
      Yan, X., Zhang, H., Fan, Q., Hu, J., Tao, R., Chen, Q., Iwakura, Y., Shen, W., Lu, L., Zhang, Q., and Zhang, R.
    • Journal Title

      Circ. Res.

      Volume: 120 Pages: 1116-1129

    • DOI
      10.1161/circresaha.116.310260
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Advanced glycation end products induce brain-derived neurotrophic factor release from human plateltets through the Src-family kinase activation.2017

    • Author(s)
      Furukawa, K. Fuse, I. Iwakura, Y. Sotoyama, H. Hanyu, O. Nawa, H. Sone, H. Takei, N.
    • Journal Title

      Cardiovasc. Diabetol.

      Volume: 16 Pages: 20-20

    • DOI
      10.1186/s12933-017-0505-y
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells.2017

    • Author(s)
      Fujio Keishi、Yamamoto Kazuhiko、Okamura Tomohisa
    • Journal Title

      Curr Top Microbiol Immunol.

      Volume: 410 Pages: 29-45

    • DOI
      10.1007/82_2017_59
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis.2017

    • Author(s)
      Shoda, H., Nagafuchi, Y., Tsuchida, Y., Sakurai, K., Sumitomo, S., Fujio, K., and Yamamoto, K.
    • Journal Title

      Arthritis Res Ther.

      Volume: 19 Pages: 111-111

    • DOI
      10.1186/s13075-017-1308-y
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis.2017

    • Author(s)
      Ishigaki Kazuyoshi、Kochi Yuta、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Yamaguchi Kensuke、Nagafuchi Yasuo、Nakachi Shinichiro、Kato Rika、Sakurai Keiichi、Shoda Hirofumi、Ikari Katsunori、Taniguchi Atsuo、Yamanaka Hisashi、Miya Fuyuki、Tsunoda Tatsuhiko、et al.、Yamamoto Kazuhiko
    • Journal Title

      Nat. Genet.

      Volume: 49 Pages: 1120-1125

    • DOI
      10.1038/ng.3885
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis.2017

    • Author(s)
      Nakachi Shinichiro、Sumitomo Shuji、Tsuchida Yumi、Tsuchiya Haruka、Kono Masanori、Kato Rika、Sakurai Keiichi、Hanata Norio、Nagafuchi Yasuo、Tateishi Shoko、Kanda Hiroko、Okamura Tomohisa、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Arthritis Res. Ther.

      Volume: 19 Pages: 1-11

    • DOI
      10.1186/s13075-017-1309-x
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TGF-β3 Inhibits Antibody Production by Human B Cells.2017

    • Author(s)
      Tsuchida Y, Sumitomo S, Ishigaki K, Suzuki A, Kochi Y, Okamura T, Yamamoto K, Fujio K.
    • Journal Title

      PLoS One

      Volume: 12 Pages: 0169646-0169646

    • DOI
      10.1371/journal.pone.0169646
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of tonsillar CD4+CD25-LAG3+ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.2017

    • Author(s)
      Sumitomo S, Nakachi S, Okamura T, Tsuchida Y, Kato R, Shoda H, Furukawa A, Kitahara N, Kondo K, Yamasoba T, Yamamoto K, Fujio K.
    • Journal Title

      J Autoimmun.

      Volume: 76 Pages: 75-84

    • DOI
      10.1016/j.jaut.2016.09.005
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice2017

    • Author(s)
      Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y ,Inaba K, Takahara K.
    • Journal Title

      Eur. J. Immunol.

      Volume: 47 Pages: 704-712

    • DOI
      10.1002/eji.201646814
    • NAID
      120006414202
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.2017

    • Author(s)
      Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M
    • Journal Title

      Dermatol.

      Volume: 26 Pages: 137-144

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preferencially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice.2017

    • Author(s)
      Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F.
    • Journal Title

      Eur J Immunol

      Volume: 47 Pages: 685-691

    • DOI
      10.1002/eji.201646699
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.2017

    • Author(s)
      Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H.
    • Journal Title

      J Immunol

      Volume: 198 Pages: 61-70

    • DOI
      10.4049/jimmunol.1502393
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pre-Transplantation Blockade of TNF-alpha-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells2017

    • Author(s)
      Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
    • Journal Title

      Stem Cells

      Volume: 35 Pages: 989-1002

    • DOI
      10.1002/stem.2524
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis2016

    • Author(s)
      Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
    • Journal Title

      Proceedings of National Academy of Sciences of the United States of America

      Volume: 113 Pages: 14097-14102

    • DOI
      10.1073/pnas.1617903113
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lyn Kinase suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity2016

    • Author(s)
      Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
    • Journal Title

      Immunity

      Volume: 45 Pages: 319-32

    • DOI
      10.1016/j.immuni.2016.07.015
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] PGE2 induced in and released by dying cells functions as an inhibitory DAMP2016

    • Author(s)
      Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A.

      Volume: 113 Pages: 3844-3849

    • DOI
      10.1073/pnas.1602023113
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.2016

    • Author(s)
      Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Pages: 8131-8140

    • DOI
      10.1073/pnas.1611286114
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Isolation of joint-infiltrating cells.2016

    • Author(s)
      Akitsu A, Iwakura Y.
    • Journal Title

      Bio-Protocol.

      Volume: 6

    • DOI
      10.21769/bioprotoc.1911
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation2016

    • Author(s)
      Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
    • Journal Title

      Immunity

      Volume: 45(6) Pages: 1299-1310

    • DOI
      10.1016/j.immuni.2016.11.010
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. Immun2016

    • Author(s)
      Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G.
    • Journal Title

      Immunity, Inflammation and Disease

      Volume: 4 Pages: 401-412

    • DOI
      10.1002/iid3.121
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two types of IL-17A-producing γδ T cells in protection against pulmonary infection with Klebsiella pneumoniae.2016

    • Author(s)
      Murakami T., Hatano S., Yamada H., Iwakura Y., Yoshikai Y.
    • Journal Title

      J Infect Dis.

      Volume: 214 Pages: 1752-1761

    • DOI
      10.1093/infdis/jiw443
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IL-21 inhibits IL-17A-producing γδ T cell response after infection with Bacillus Calmette-Guerin via induction of apoptosis.2016

    • Author(s)
      Huang Y., Matsumura Y., Hatano, S., Noguchi N., Murakamia, T., Iwakura Y., Sun X., Oharad N., Yoshikai Y.
    • Journal Title

      Innate Immun.

      Volume: 22 Pages: 588-597

    • DOI
      10.1177/1753425916664125
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets.2016

    • Author(s)
      Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.
    • Journal Title

      Diabetes.

      Volume: 65

    • DOI
      10.2337/db16-ec08a
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs2016

    • Author(s)
      Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 138 Pages: 1458-1461

    • DOI
      10.1016/j.jaci.2016.04.047
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] IL-17A-producing CD30+ Vδ1 T cells drive inflammation-induced cancer progression2016

    • Author(s)
      Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.
    • Journal Title

      Cancer Sci

      Volume: 107 Pages: 1106-1214

    • DOI
      10.1111/cas.13005
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016

    • Author(s)
      Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 17629-17638

    • DOI
      10.1074/jbc.m116.741256
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Adiponectin enhances antibacterial activity of hematopoietic cells by suppressing bone marrow inflammation.2016

    • Author(s)
      Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M.
    • Journal Title

      Immunity

      Volume: 44 Pages: 1422-1433

    • DOI
      10.1016/j.immuni.2016.05.010
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.2016

    • Author(s)
      Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA.
    • Journal Title

      J Immunol.

      Volume: 197 Pages: 278-287

    • DOI
      10.4049/jimmunol.1502485
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.2016

    • Author(s)
      Fabio Yoshikawa, Rikio Yabe, Yoichiro Iwakura, Sandro Rogerio de Almeida, Shinobu Saijo
    • Journal Title

      Innate Immun.

      Volume: in press Pages: 316-24

    • DOI
      10.1177/1753425916645392
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension.2016

    • Author(s)
      Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS.
    • Journal Title

      Hypertension

      Volume: 68 Pages: 167-74

    • DOI
      10.1161/hypertensionaha.116.07493
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system2016

    • Author(s)
      Shishikura, M., Nakamura, F., Yamashita, N., Uetani, N., Iwakura, Y., and Goshima, Y.
    • Journal Title

      Brain Res

      Volume: 1642 Pages: 244-254

    • DOI
      10.1016/j.brainres.2016.03.030
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.2016

    • Author(s)
      Martin, B. N. , et al.
    • Journal Title

      Nat Immunol.

      Volume: 17 Pages: 583-592

    • DOI
      10.1038/ni.3389
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy.2016

    • Author(s)
      Javed, N., Xue, G., Lu, A., Xing, Y., Iwakura, Y., Xiao, H., Lecoeur, H., Spath, G. F., and Meng, G.
    • Journal Title

      Cytokine

      Volume: 81 Pages: 101-108

    • DOI
      10.1016/j.cyto.2016.03.007
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo.2016

    • Author(s)
      Ciraci, C., Janczy, J. R., Jain, N., Haasken, S., Pecli, E. Silva, C., Benjamim, C. F., Sadler, J. J., Olivier. A. K., Iwakura, Y., Shayakhmetov, D. M., Sutterwala, F. S., and Cassel, S. L.
    • Journal Title

      Plos One

      Volume: 11

    • DOI
      10.1371/journal.pone.0151252
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-17-producing γ δ T cells enhance bone regeneration2016

    • Author(s)
      Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H.
    • Journal Title

      Nat Commun.

      Volume: 7 Pages: 10928-10928

    • DOI
      10.1038/ncomms10928
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye.2016

    • Author(s)
      Lee, E. J., Brown, B. R., Vance, E. E., Snow, P. E., Silver, P. B., Heinrichs, D., Lin, X., Iwakura, Y., Wells, C. A., Caspi, R. R., and Rosenzweig, H. L.
    • Journal Title

      J Immunol.

      Volume: 196 Pages: 3148-3158

    • DOI
      10.4049/jimmunol.1502355
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.2016

    • Author(s)
      Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., and Divanovic, S.
    • Journal Title

      Plos One

      Volume: 11

    • DOI
      10.1371/journal.pone.0149783
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice2016

    • Author(s)
      Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y., and Ishii, N.
    • Journal Title

      Eur J Immunol

      Volume: 46 Pages: 1119-1131

    • DOI
      10.1002/eji.201545907
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway.2016

    • Author(s)
      Mai, J., Nanayakkara, G., Lopez-Pastrana, J., Li, X., Li, Y. F., Wang, X., Song, A., Virtue, A., Shao, Y., Shan, H., Liu, F., Autieri, M. V., Kunapuli, S. P., Iwakura, Y., Jiang, X., Wang, H., Yang, X. F.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 4939-4954

    • DOI
      10.1074/jbc.m115.690081
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis.2016

    • Author(s)
      Saigusa R, Asano Y, Taniguchi T, Yamashita T, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sugawara K, Tsuruta D, Taniguchi T, Sato S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 112 Pages: 15136-41

    • DOI
      10.1073/pnas.1520997112
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.2016

    • Author(s)
      Teijaro J. R., Studer S., Leaf N., Kiosses, W.B., Nguyen N., Matsuki K., Negishi H., Taniguchi T., Oldstone M.B.A., and Rosen H.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A.

      Volume: 113 Pages: 1351-6

    • DOI
      10.1073/pnas.1525356113
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bone marrow transplantation alters lung antigen-presenting cells to promote Th17 reponse and the development of pneumonitis and fibrosis following gammaherpesvirus infection.2016

    • Author(s)
      Zhou, X., Loomis-King, H., Gurczynski, S. J., Wilke, C. A., Konopka, K. E., Ptaschinski, C., Coomes, S. M., Iwakura, Y., van Dyk, L. F., Lukacs, N. W., and Moore, B. B.
    • Journal Title

      Mucosal Immunol

      Volume: 9 Pages: 610-20

    • DOI
      10.1038/mi.2015.85
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1 receptor antagonist inhibits pancreatic cancer growth by abrogating NF-κB activation.2016

    • Author(s)
      Zhuang, Z. N., Ju, H. Q., Aguilar, M., Gocho, T., Li, H., Iida, T., Lee, H., Fan, X., Zhou, H., Ling, J., Li, Z., Fu, J., Wu, M., Li, M., Melisi, D., Iwakura, Y., Xu, K., Fleming, J. B., and Chiao, P. J.
    • Journal Title

      Clin. Cancer Res.

      Volume: 22 Pages: 1432-1444

    • DOI
      10.1158/1078-0432.ccr-14-3382
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis.2016

    • Author(s)
      Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
    • Journal Title

      Inflamm Res.

      Volume: 65 Pages: 235-244

    • DOI
      10.1007/s00011-015-0910-1
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae.2016

    • Author(s)
      Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
    • Journal Title

      BMC Immunol.

      Volume: 17 Pages: 1-1

    • DOI
      10.1186/s12865-015-0139-3
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.2015

    • Author(s)
      Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito, H, Taniguchi T, Matsumoto M, Seya T
    • Journal Title

      J Exp Med.

      Volume: 207(12) Pages: 1337-1337

    • DOI
      10.1084/jem.20091573
    • NAID
      120002722561
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response2015

    • Author(s)
      Okazaki T., Higuchi M., Takeda K., Iwatsuki-Horimoto K., Kiso M., Miyagishi M., Yanai H., Kato A., Yoneyama M., Fujita T., Taniguchi T., Kawaoka Y., Ichijo H. and Gotoh Y.
    • Journal Title

      Sci. Signal.

      Volume: 8 Pages: 1-12

    • DOI
      10.1126/scisignal.aab1883
    • NAID
      120006348502
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.2015

    • Author(s)
      Nishio J, et al.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A.

      Volume: 112 Pages: 12770-12775

    • DOI
      10.1073/pnas.1516617112
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetics of rheumatoid arthritis in Asia―present and future2015

    • Author(s)
      Yamamoto K, Okada Y, Suzuki A, Kochi Y.
    • Journal Title

      Nat.Rev.Rheumatol

      Volume: AOP Pages: 375-379

    • DOI
      10.1038/nrrheum.2015.7
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β3-expressing CD4+CD25-LAG3+ regulatory T cells control humoral immune responses2015

    • Author(s)
      Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.
    • Journal Title

      Nat Communications

      Volume: 6 Pages: 1-14

    • DOI
      10.1038/ncomms7329
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization.2015

    • Author(s)
      Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N.
    • Journal Title

      Mucosal Immunol.

      Volume: 8 Pages: 735-745

    • DOI
      10.1038/mi.2014.105
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages.2015

    • Author(s)
      Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, Horai R, Kakuta S, Watanabe T, Iwakura Y.
    • Journal Title

      J. Immunol

      Volume: 194(7) Pages: 3156-3168

    • DOI
      10.4049/jimmunol.1402155
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015

    • Author(s)
      Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.:
    • Journal Title

      Blood

      Volume: 125 Pages: 3014-23

    • DOI
      10.1182/blood-2014-12-615781
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mast cells mediate malignant pleural effusion formation.2015

    • Author(s)
      Giannou, A. D. et al
    • Journal Title

      J. Clin. Invest.

      Volume: 125 Pages: 2317-2334

    • DOI
      10.1172/jci79840
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DCIR maintains bone homeostasis by regulating IFN-g;production in T cells.2015

    • Author(s)
      Maruhashi T*, Kaifu T*, Yabe R, Seno A, Chung SH, Fujikado N, and Iwakura Y
    • Journal Title

      J. Immunol.

      Volume: 194 Pages: 5681-5691

    • DOI
      10.4049/jimmunol.1500273
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD11c+ DCs accelerate the rejection of older cardiac transplants via IL-17A.2015

    • Author(s)
      Oberhuber, R., Heinbokel, T., Cetina Biefer, H. R., Boenisch, O., Hock, K., Bronson, R. T., Wilhelm, M. J., Iwakura, Y., Edtinger, K., Uehara, H., Quante, M., Voskuil, F., Krenzien, F., Slegtenhorst, B., Abdi, R., Pratschke, J., Elkhal, A., and Tullius, S. G.
    • Journal Title

      Circulation

      Volume: 132 Pages: 122-131

    • DOI
      10.1161/circulationaha.114.014917
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like hehavior by aging.2015

    • Author(s)
      Wakabayashi et al.
    • Journal Title

      Neuroscience Letters

      Volume: 599 Pages: 20-25

    • DOI
      10.1016/j.neulet.2015.05.019
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells.2015

    • Author(s)
      Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y.
    • Journal Title

      Nat. Commun.

      Volume: 6 Pages: 7464-7464

    • DOI
      10.1038/ncomms8464
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia2015

    • Author(s)
      Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
    • Journal Title

      Nat. Commun.

      Volume: 10;6 Pages: 7514-7514

    • DOI
      10.1038/ncomms8514
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mouse model for PTPRD associations with WED/RLS and addiction: reduced expansion alters locomotion, sleep behaviors and cocaine-conditioned place preference.2015

    • Author(s)
      Drgonova, J., Walther, D., Wang, K. J., Hartstein, G. L., Lochte, B., Troncoso, J., Uetani, N., Iwakura, Y., and Uhl, G. R.
    • Journal Title

      Mol. Med.

      Volume: 21 Pages: 717-725

    • DOI
      10.2119/molmed.2015.00017
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine.2015

    • Author(s)
      Ce Tang, Tomonori Kamiya, Yang Liu, Motohiko Kadoki, Shigeru Kakuta, Kenshiro Oshima, Masahira Hattori, Kozue Takeshita, Takanori Kanai, Shinobu Saijo and Yoichiro Iwakura
    • Journal Title

      Cell Host Microbe

      Volume: 18 Pages: 183-197

    • DOI
      10.1016/j.chom.2015.07.003
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Local IL-17 production exerts a protective role in murine experimental glomerulonephritis.2015

    • Author(s)
      Hamour, S., Gan, P. Y., Pepper, R., Florez Barros, F., Wang, H. H., O'Sullivan, K., Iwakura, Y., Cook, T., Pusey, C., Holdsworth, S., and Salama, A.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI
      10.1371/journal.pone.0136238
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense.2015

    • Author(s)
      Cai, S., Batra, S., Langohr, I., Iwakura, Y., and Jeyaseelan, S.
    • Journal Title

      Mucosal Immunol

      Volume: 9 Pages: 718-29

    • DOI
      10.1038/mi.2015.95
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.2015

    • Author(s)
      Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
    • Journal Title

      Nat. Commun.

      Volume: 6 Pages: 1-12

    • DOI
      10.1038/ncomms9483
    • NAID
      120005672443
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dendritic cell immunoreceptor 1 alters neutrophil response in the development of experimental colitis.2015

    • Author(s)
      Tokieda, S., Komori, M., Ishiguro, Iwakura, Y., Takahara, K.* and Inaba, K.
    • Journal Title

      BMC Immunol

      Volume: 16 Pages: 64-64

    • DOI
      10.1186/s12865-015-0129-5
    • NAID
      120005689211
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interdependence between interleukin-1 and tumor necrosis factor regulates TNF-dependent control of Mycobacterium tuberculosis infection.2015

    • Author(s)
      Di Paolo, N. C., Shafiani, S., Day, T., Papayannoupoulou, T., Russell, D. W., Iwakura, Y., Sherman, D., Urdahl, K., and Shayakhmetov, D. M.
    • Journal Title

      Immunity

      Volume: 43 Pages: 1125-36

    • DOI
      10.1016/j.immuni.2015.11.016
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 炎症性疾患発症におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      第221回日本皮膚科学会熊本地方会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 炎症性疾患および免疫系の恒常性維持におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      ノバルティスTAPの会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腸管免疫の恒常性維持におけるC型レクチンおよびIL-17Fの役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本生物学研究所セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 炎症性疾患および免疫系の恒常性維持におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      乾癬エキスパートミーティング in 関東甲信越
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Immune and Bone Metabolic Abnormalities in Dcir-deficient Mice.2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本骨代謝学会 学会合同シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 炎症性疾患発症におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本炎症再生医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 食品の腸内環境に及ぼす影響と疾病との関連2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      第26回日本臨床環境医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 炎症応答におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      埼玉IL-17Aフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Role of HMGB1 in inflammation and immunity; implication in transplantation2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      2017 Seoul Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Virtue and vice of the immune system: Self-derived molecules and molecular mechanisms that underlie the regulation of inflammation and cancer.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of inflammation and tumor growth by DAMPs.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      2017 SAB Meeting of Tsinghua Institute for Immunology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] From Type I IFN to HMGB1 and other DAMP molecules: Regulators of immunity, inflammation and cancer.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      International Cytokine Interferon Society Meeting (ICIS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] From Qβ to another phage: Regulation of intestinal inflammation by a new bacteriophage.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      The End of the Beginning, Symposium of Molecular Biology Zurich
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DAMPs, inflammation and cancer.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      2017 Changchun Forum on Research of Immunology and Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Innate immune receptors in the regulation of tumor immunity.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      Immuno-Oncology Summit 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HMGB1 and other DAMPs in the regulation of inflammation and cancer.2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      Cancer, Inflammation, and Immunity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of Dectin-1-IL-17F axis in the homeostasis of the intestinal immune system.2017

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      International Cytokine Interferon Society Meeting (ICIS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of Dectin-1-IL-17F axis in the homeostasis of the intestinal immune system. Inner Cosmos of the Body-Immunity, Tumors and Inflammation-2017

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      International Symposium of the Center for Animal Disease Models 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dectins and IBD Fungi/Dectins and mucosal immunity2017

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      18th International Congress of Mucosal Immunity (ICMI2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel animal models in arthritis Novel Animal Models in Rheumatoid Arthritis2017

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Joint EULAR-APLAR session, EULAR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of C-type lectins in the immune system2017

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      BI/Kyoto University Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DAMPs, Inflammation and Associated Diseases; The End of the Beginning?2017

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      Sanofi China Academy of Medical Science (CAMS) Symposium on Innovative Medicine
    • Place of Presentation
      Jiangsu, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 炎症性腸疾患と食物アレルギーの病態制御におけるDectin-1と短鎖βグルカンの役割の解析2017

    • Author(s)
      唐策、岩倉洋一郎
    • Organizer
      Glyco-Immunology 2017糖鎖免疫研究会
    • Place of Presentation
      東京都 東京医科歯科大学 M&Dタワー
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 炎症性疾患及び免疫系の恒常性維持におけるIL-17の役割2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      第40回皮膚脈管・膠原病研究会
    • Place of Presentation
      福島県 コラッセ福島
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 低分子βグルカンによる腸管免疫の制御2017

    • Author(s)
      岩倉洋一郎
    • Organizer
      第1回千葉プロバイオティックス学術セミナー
    • Place of Presentation
      千葉県 アパホテル&リゾート東京ベイ幕張
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A novel role of Dectin-1 signaling in controlling food antigen-induced mouse intestinal allergy2016

    • Author(s)
      唐策、濱田有史、岩倉洋一郎
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄県 沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of novel IL-17-producing T cell populations, γδ TCR-CD4-CD8- cells, in TCRd -deficient mice.2016

    • Author(s)
      Aoi Akitsu, Yoichiro Iwakura.
    • Organizer
      4th Annual Meeting of the International Cytokine & Interferon Society (ICIS).
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 補体制御因子CTRP6と炎症性疾患2016

    • Author(s)
      村山正承、岩倉洋一郎
    • Organizer
      第3回日本リウマチ学会ベーシックリサーチカンファレンス.
    • Place of Presentation
      東京都 アキバプラザ
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] DCIR-糖鎖間相互作用による骨代謝制御機構.2016

    • Author(s)
      矢部力朗、海部知則、丸橋拓海、西城忍、舘野浩章、平林淳、岩倉洋一郎
    • Organizer
      第35回日本糖質年会
    • Place of Presentation
      高知県 高知市文化プラザ
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillusmediated regulatory T cell expansion in the intestine.2016

    • Author(s)
      Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
    • Organizer
      International Congress of Immunology (ICI) 2016
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells.2016

    • Author(s)
      Aoi Akitsu, Yoichiro Iwakura.
    • Organizer
      International Congress of Immunology (ICI) 2016
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Complement regulator CTRP6 and inflammatory diseases.2016

    • Author(s)
      Masanori A. Murayama, Kenzo Matsuo, Kaori Yoshida, Nanako Katagiri, Yoichiro Iwakura.
    • Organizer
      9th International Conference on Complement Therapeutics. Rhodes, Greece.
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2016-06-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 補体制御因子CTRP6と炎症性疾患2016

    • Author(s)
      村山正承、松尾謙蔵、吉田佳織、片桐菜々子、岩倉洋一郎
    • Organizer
      第81回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      長崎県 長崎大学坂本キャンパス良順会館
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] IL-1Ra KOマウスにおける胸腺T細胞分化の解析2016

    • Author(s)
      秋津葵、 岩倉洋一郎
    • Organizer
      第26回Kyoto T cells conference.
    • Place of Presentation
      京都府 比叡山延暦寺会館
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation of inflammatory responses by self and non-self molecule2016

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      International Symposium on Advanced Immunology
    • Place of Presentation
      大阪府 大阪国際コンベンションセンター
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of intestinal inflammation by SP-D2016

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      The 3rd Symposium Max Planck-The University of Tokyo Center for Integrative Inflammology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NOVEL THERAPEUTIC TARGETS IN AUTOIMMUNITY - TGF-beta3 AS A NOVEL TARGET OF IMMUNOTHERAPY2016

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      10th International Congress on Autoimmunity
    • Place of Presentation
      Germany
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diagnosis and treatment of rheumatoid arthritis2016

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      21st Hong Kong Medical Forum
    • Place of Presentation
      Hong Kong
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genomics and functional genomics of rheumatoid arthritis2016

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      the 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR )
    • Place of Presentation
      Shanghai, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system.2016

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2016
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of C-type lectin receptors in the homeostasis of the intestinal immune system.2016

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      National Defense Medical Center (Sponsored by Prof. Ann Chen)
    • Place of Presentation
      Taipei, ROC
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of C-type lectins in host defense against pathogens and homeostasis of the immune system.2016

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Genomics Research Center Seminar Series
    • Place of Presentation
      Taipei, ROC
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シンポジウム17「リウマチ性疾患における自己免疫と自然免疫」2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      第60回日本リウマチ学会総会学術集会
    • Place of Presentation
      神奈川県 パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己免疫疾患と感染防御におけるIL-17ファミリーの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      御茶ノ水乾癬勉強会
    • Place of Presentation
      東京都 TKRガーデン・シティー御茶ノ水
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 炎症および感染防御におけるIL-17AとIL-17Fの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      皮膚科学会モーニングセミナー
    • Place of Presentation
      京都府 京都国際会館
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己免疫疾患と感染防御におけるIL-17ファミリーの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      四国4大学皮膚科研究会
    • Place of Presentation
      愛媛県 松山全日空ホテル
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己免疫疾患と感染防御におけるIL-17ファミリーの役割2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      Psoriasis and IL-17A Forum 2016 in Kyushu
    • Place of Presentation
      福岡県 博多エクセルホテル東急
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 短鎖βグルカンによる腸内細菌を介した免疫制御2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      東海大学医学部講演会
    • Place of Presentation
      神奈川県 伊勢原
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 短鎖βグルカンによる腸管免疫恒常性の維持2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本臨床免疫学会シンポジウム1
    • Place of Presentation
      東京都 京王プラザホテル
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自然免疫受容体を介した真菌の認識と免疫系の修飾2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本医真菌学会教育講演3
    • Place of Presentation
      東京都 都立産業貿易センター
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 疾患モデルを用いた自己免疫および感染防御機構の解析と創薬への展開2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      自治医科大学大学院特別講義(医学研究科教育委員会主催)
    • Place of Presentation
      茨城県 自治医科大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 低分子βグルカンによる腸管炎症抑制2016

    • Author(s)
      岩倉洋一郎
    • Organizer
      バイオジャパン
    • Place of Presentation
      神奈川県 パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Pathogenic Mechanisms of Psoriasis: Lessons from Mouse Models2016

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      日本研究皮膚科学会第41回年次学術大会
    • Place of Presentation
      宮城県 仙台国際センター
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DCIR maintains bone homeostasis by regulating IFN-g; production in T cells.2015

    • Author(s)
      Tomonori Kaifu, Takumi Maruhashi, Rikio Yabe, Soo-hyun Chung,N, Yoichiro Iwakura.
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      北海道札幌市 札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine.2015

    • Author(s)
      Ce Tang, Tomonori Kamina, Yoichiro Iwakura.
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS)
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DCIR maintains bone homeostasis by regulating IFN-γ production in T cells.2015

    • Author(s)
      Tomonori Kaifu, Takumi Maruhashi, Rikio Yabe, Soo-hyun Chung, Akimasa Seno, Noriyuki Fujikado, Yoichiro Iwakura.
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS)
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CTRP6, complement regulator, effectively treats induced arthritis.2015

    • Author(s)
      Masanori Murayama, Yoichiro Iwakura.
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS)
    • Place of Presentation
      Bamberg, Germany
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] C型レクチン受容体DCIR欠損マウスで認められた関節強直と骨量増加の病態解析2015

    • Author(s)
      海部知則、丸橋拓海、矢部力朗、鄭琇絢、妹尾彬正、藤門範行、岩倉洋一郎
    • Organizer
      日本リウマチ学会第2回JCRベーシックリサーチカンファレンス
    • Place of Presentation
      東京都 東京大学内(本郷)鉄門記念講堂, 伊藤謝恩ホール
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自己免疫発症における補体第二経路特異的制御因子CTRP6の役割2015

    • Author(s)
      村山正承、吉田佳織、松尾謙蔵、岩倉洋一郎
    • Organizer
      第52回日本補体学会学術集会
    • Place of Presentation
      愛知県名古屋市 名古屋大学医学部附属病院
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] IL-17産生性γδT細胞によるIL-1Ra KOマウスの関節炎発症メカニズム.2015

    • Author(s)
      秋津葵、角田茂、 西城忍、 岩倉洋一郎
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京都 東京工業大学
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新たな補体制御因子CTRP6による補体制御機構および関節リウマチに対する治療効果の検討.2015

    • Author(s)
      村山正承、岩倉洋一郎
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京都 東京工業大学
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大腸炎発症におけるIL-1受容体II型の機能解析2015

    • Author(s)
      吉田佳織、清水謙次、村山正承、岩倉洋一郎
    • Organizer
      第80回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      東京都 東京工業大学
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Regulation of anti-tumor immune innate immune responses: implications to cancer therapeutics2015

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      9th Symposium Progress Towards Individualized Cancer Therapeutics
    • Place of Presentation
      Rijeka, Croatia
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recognition of self-derived moleculer inflammation and antitumor immunity2015

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      19th International Fritz-Bender Foundation Symposium on Cancer Biology for Cancer Therapeutics
    • Place of Presentation
      Pisa, Italy
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of inflammation and anti-tumor innate immunity by self-derived molecules2015

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      Tumor Immunology and Immunotherapy, Cold Spring Harbor Asia Conference
    • Place of Presentation
      Suzhou, China
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Innate immune responses in the regulation of tumor development2015

    • Author(s)
      Tadatsugu Taniguchi
    • Organizer
      Third Annual Meeting of the International Cytokine & Interferon Society (ICIS)
    • Place of Presentation
      Bamberg, Germany
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulatory T cells in human diseases2015

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      11th International Congress on Systemic Lupus Erythematosus
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel regulatory T cell subset controlling B cell functions: a combination of therapeutic cytokines2015

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      7th International Forum on Rheumatoid Arthritis (IFRA)
    • Place of Presentation
      Beijing, China
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析と治療への応用2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      第26回日本生体防御学会
    • Place of Presentation
      東京都 台東区生涯学習センターミレミアムホール
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The role of Dectin-1 in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      International Symposium of the Center for Animal Disease Models 2015
    • Place of Presentation
      Tokyo, Tokyo University of Science, Gakushi-kaikan
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Basic Research for Infection, Inflammation, and Immunity Using Gene-Modified Mice2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Dalian Medical University
    • Place of Presentation
      Dalian, China
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CTRP6: A Novel Complement Regulator. International Symposium on Immune Regulation2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      University of Tsukuba
    • Place of Presentation
      千葉県 千葉大学
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      National Defense Medical Center
    • Place of Presentation
      Taipei
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自己免疫疾患および感染防御におけるIL-17A、IL-17Fの役割の解明2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      野口英世記念医学賞受賞記念講演
    • Place of Presentation
      福島県 猪苗代町体験交流館学びいなホール
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 関節リウマチのモデル動物」第9回 in vivo実験医学シンポジウム「免疫疾患における動物モデルを用いた病態解明と治療への応用2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      公益財団法人実験動物中央研究所
    • Place of Presentation
      東京都 学士会館
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Shenzhen Institute of Advanced Technology
    • Place of Presentation
      Shenzhen, China
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The roles of C-type lectin receptors in the homeostasis of the intestinal immune system2015

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Advanced Institute for Medical Sciences, Dalian Medical University
    • Place of Presentation
      Dalian, China
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腸管免疫の恒常性維持に於けるC型レクチンの役割2015

    • Author(s)
      岩倉洋一郎
    • Organizer
      千葉大学真菌医学 研究センターセミナー
    • Place of Presentation
      千葉県 千葉大学真菌医学 研究センター
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] トピックス 「自己免疫疾患に対する新たな治療標的の発見」2017

    • Author(s)
      村山正承、岩倉洋一郎
    • Total Pages
      4
    • Publisher
      理大科学フォーラム
    • Related Report
      2016 Annual Research Report
  • [Book] セミナー室「低分子βグルカン摂取により炎症性腸疾患を予防,改善する」2016

    • Author(s)
      唐策、角田茂、岩倉洋一郎
    • Total Pages
      6
    • Publisher
      日本農芸化学会
    • Related Report
      2016 Annual Research Report
  • [Book] Dendritic Cell Immunoreceptor (DCIR): An ITIM-Harboring C-Type Lectin Receptor.2016

    • Author(s)
      Tomonori Kaifu and Yoichiro Iwakura.
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Book] IL-1ファミリー分子による免疫制御2016

    • Author(s)
      秋津葵、岩倉洋一郎
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2016 Annual Research Report
  • [Book] 自己免疫性関節炎と病原性T細胞2016

    • Author(s)
      秋津葵、岩倉洋一郎
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2016 Annual Research Report
  • [Remarks] UTokyo Research: がんの肝転移を抑える新たなしくみを発見

    • URL
      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/newly-discovered-mechanism-prevents-spread-of-cancer-to-liver.html
    • Related Report
      2017 Annual Research Report
  • [Remarks] UTokyo Research: 死んだ細胞から放出される免疫抑制分子を同定

    • URL
      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/dead-cell-derived-immunosuppressive-molecule-identified.html
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-06-03   Modified: 2019-07-17  

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