皮膚を場とする外的刺激に対する生体応答機構の包括的解明

• Project/Area Number: 15H05790
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyoto University
• Principal Investigator: 椛島 健治 京都大学, 医学研究科, 教授 (00362484)
• Co-Investigator(Kenkyū-buntansha): 大日 輝記 京都大学, 医学研究科, 講師 (20423543) ; 國澤 純 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, センター長 (80376615)
• Project Period (FY): 2015-05-29 – 2020-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥191,100,000 (Direct Cost: ¥147,000,000、Indirect Cost: ¥44,100,000); Fiscal Year 2019: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000); Fiscal Year 2018: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000); Fiscal Year 2017: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000); Fiscal Year 2016: ¥60,190,000 (Direct Cost: ¥46,300,000、Indirect Cost: ¥13,890,000); Fiscal Year 2015: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
• Keywords: 皮膚科学 / 皮膚 / 免疫 / アレルギー / 免疫学 / アレルギー・ぜんそく / 生体イメージング / 皮膚免疫

Outline of Annual Research Achievements

申請者は、外的侵襲に対する獲得免疫反応の惹起時に、皮膚内にリンパ様組織構築（Skin-Associated Lymphoid Tissue; SALT）が誘導される事を見出し、本構築をinducible SALT: iSALTと命名した。本研究課題では、外的侵襲に対する皮膚応答機構を理解し、各種皮膚疾患の発症機序を解明する事を目的とする。
本年度は、皮膚の構成細胞・構造物・細胞機能を包括的に可視化する系の確立と、SALT形成の際に重要な役割を果たす後毛細血管静脈の果たす役割の解析を行った。
当初の目的であったマウス皮膚の可視化に関しては、皮膚の構造物、各種皮膚構成細胞と細胞機能の可視化に成功した。また、外的侵襲に対するマウス皮膚の生体応答の解明を目指し、iSALT形成における上皮・免疫・間質細胞の役割を解明した。また、ハプテンのみならずタンパク抗原や自然免疫系シグナルなどの外的刺激に対するiSALTの生理・病態的役割の解明も明らかにした。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

皮膚は、バリア機能、免疫、かゆみを介して、極めて合目的的に外的侵襲の排除に関与する。一方で、アトピー性皮膚炎での「病的な」かゆみの発生は患者の生活の質を著しく低下させる。IL-31はアトピー性皮膚炎の皮膚に局在するT細胞が産生し、神経細胞週末のIL-31受容体に直接作用することでかゆみを生じさせることがマウスで知られていたがヒトでの役割は不明であった。本研究では、アトピー性皮膚炎の患者を対象に、ヒト化抗ヒトIL-31受容体抗体 (nemolizumab) の効果を検証した。抗IL-31受容体抗体の投与群は対照群に比べて有意にかゆみを軽減し、皮疹の重症度も軽減した。以上より、免疫細胞がサイトカイン産生を介して末梢神経に作用してかゆみを誘導し、アトピー性皮膚炎の病態を形成していることを明らかとした。
また、代表者が提案したiSALTの概念がヒトの皮膚感染症や炎症性疾患にも適用されるか否かを検証した。梅毒ではその感染局所において形質細胞の浸潤が早期からみられることから、梅毒の第2期疹でiSALT構造の探索を行った。梅毒の第2期疹では、菌体に近接して、TおよびBリンパ球、高内皮細静脈より構成されるiSALT様の構造を認め、CXCL13陽性線維芽細胞様細胞を豊富に含んでいた。以上より、マウスで観察されたiSALTに相当する構造が皮膚感染症においてヒトでも形成される可能性が示された。現在、エリテマトーデスやメラノーマなどの他の疾患におけるiSALTの存在の確認とその意義の解明を進めている。
したがって、初年度に達成するべき研究成果は十分得られており、概ね順調に進呈していると考える。

Strategy for Future Research Activity

外的侵襲に対するヒト皮膚の生体応答の包括的解明
1) ヒト皮膚構造物・構成細胞の可視化
これまでマウスを中心に確立してきた手法を用い、健常ヒト皮膚の構成細胞や構造物の蛍光可視化を順次試みる。
2) ヒト各種皮膚疾患におけるiSALTと常在菌の意義の検証
三次元でヒト皮膚の病理組織を可視化する技術を確立する。ヒトiSALTの有無と皮膚常在菌のプロファイルを接触皮膚炎、アトピー性皮膚炎や尋常性乾癬などの炎症性皮膚疾患において検証し、病態解明の基盤を形成する。さらに、ex vivoでのリアルタイム生体イメージングシステムの確立を目指す。

Assessment Rating

Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Research Products

• [Journal Article] Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. (2019)
  • Author(s): Chakarov S, Lim HY, Tan L, Lim SY, See P, Lum J, Zhang XM, Foo S, Nakamizo S, Duan K, Kong WT, Gentek R, Balachander A, Carbajo D, Bleriot C, Malleret B, Tam JKC, Baig S, Shabeer M, Toh SES, Schlitzer A, Larbi A, Marichal T, Malissen B, Chen J, Poidinger M, Kabashima K, Bajenoff M, Ng LG, Angeli V, Ginhoux F.
  • Journal Title: Science. Volume: 15
  • DOI: 10.1126/science.aau0964
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antigen presentation and adaptive immune responses in skin. (2019)
  • Author(s): Honda T, Egawa G, Kabashima K.
  • Journal Title: Int Immunol. Volume: 0 Pages: 0-0
  • DOI: 10.1093/intimm/dxz005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Insights into atopic dermatitis gained from genetically defined mouse models. (2019)
  • Author(s): Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Iraoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T.
  • Journal Title: J Allergy Clin Immunol. Volume: 130 Pages: 13-25
  • Peer Reviewed
• [Journal Article] The immunological anatomy of the skin. (2019)
  • Author(s): Kabashima Kenji、Honda Tetsuya、Ginhoux Florent、Egawa Gyohei
  • Journal Title: Nat Rev Immunol. Volume: 19 Pages: 19-30
  • DOI: 10.1038/s41577-018-0084-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis. (2018)
  • Author(s): Dainichi Teruki、Kitoh Akihiko、Otsuka Atsushi、Nakajima Saeko、Nomura Takashi、Kaplan Daniel H.、Kabashima Kenji
  • Journal Title: Nat Immunol. Volume: 19 Pages: 1286-1298
  • DOI: 10.1038/s41590-018-0256-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation. (2018)
  • Author(s): Matsumoto R, Dainichi T, Tsuchiya S, Nomura T, Kitoh A, Hayden MS, Ishii KJ, Tanaka M, Honda T, Egawa G, Otsuka A, Nakajima S, Sakurai K, Nakano Y, Kobayashi T, Sugimoto Y, Kabashima K.
  • Journal Title: JCI Insight. Volume: 9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study. (2018)
  • Author(s): Kabashima K, Furue M, Hanifin JM, Pulka G, Wollenberg A, Galus R, Etoh T, Mihara R, Nakano M, Ruzicka T.
  • Journal Title: J Allergy Clin Immunol. Volume: 142(4)
  • DOI: 10.1016/j.jaci.2018.03.018
  • NAID: 120006601464
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model. (2018)
  • Author(s): Sachiko Ono, Gyohei Egawa, Tetsuya Honda, and Kenji Kabashima
  • Journal Title: J Allergy Clin Immunol. Volume: 印刷中
  • DOI: 10.1016/j.jaci.2017.12.985
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue. (2018)
  • Author(s): Kusuba Nobuhiro、Kitoh Akihiko、Dainichi Teruki、Honda Tetsuya、Otsuka Atsushi、Egawa Gyohei、Nakajima Saeko、Miyachi Yoshiki、Kabashima Kenji
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 141
  • DOI: 10.1016/j.jaci.2017.07.033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Receptor-interacting protein kinase 3 controls keratinocyte activation in a necroptosis-independent manner and promotes psoriatic dermatitis in mice. (2017)
  • Author(s): Tetsuya Honda, Osamu Yamamoto MD, Yu Sawada, Gyohei Egawa, Akihiko Kitoh, Atsushi Otsuka, Teruki Dainichi, Saeko Nakajima, Yoshiki Miyachi, Kenji Kabashima
  • Journal Title: J Allergy Clin Immunol. Volume: 5
  • DOI: 10.1016/j.jaci.2017.02.027
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis. (2017)
  • Author(s): Ruzicka T, Hanifin JM, Furue M, Pulka G, Mlynarczyk I, Wollenberg A, Galus R, Etoh T, Mihara R, Yoshida H, Stewart J, Kabashima K; XCIMA Study Group.
  • Journal Title: N Engl J Med. Volume: 2;376(9) Pages: 826-835
  • DOI: 10.1056/nejmoa1606490
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Local inflammation exacerbates cutaneous manifestations in a murine autoimmune pemphigus model. (2017)
  • Author(s): S. Ono, G. Egawa, A. Kitoh, T. Dainichi, A. Otsuka, S. Nakajima, T, Honda, K. Kabashima
  • Journal Title: J Allergy Clin Immunol. Volume: 印刷中
  • DOI: 10.1016/j.jaci.2016.12.959
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma (2017)
  • Author(s): Honda Y, Otsuka A, Ono S, Yamamoto Y, Seidel JA, Morita S, Hirata M, Kataoka TR, Takenouchi T, Fujii K, Kanekura T, Okubo Y, Takahashi K, Yanagi T, Hoshina D, Hata H, Abe R, Fujimura T, Funakoshi T, Yoshino K, Masuzawa M, Amoh Y, Tanaka R, Fujisawa Y, Honda T, Kabashima K.
  • Journal Title: OncoImmunology Volume: 6
  • DOI: 10.1080/2162402x.2016.1253657
  • Peer Reviewed / Open Access
• [Journal Article] Increasing Comorbidities Suggest that Atopic Dermatitis?Is?a?Systemic Disorder (2017)
  • Author(s): Brunner Patrick M.、Silverberg Jonathan I.、Guttman-Yassky Emma、Paller Amy S.、Kabashima Kenji、Amagai Masayuki、Luger Thomas A.、Deleuran Mette、Werfel Thomas、Eyerich Kilian、Stingl Georg、Bagot Martine、Hijnen Dirk Jan、Ardern-Jones Michael、Reynolds Nick、Spuls Phyllis、Taieb Alain
  • Journal Title: Journal of Investigative Dermatology Volume: 137 Pages: 18-25
  • DOI: 10.1016/j.jid.2016.08.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling (2017)
  • Author(s): Ewald DA, Noda S, Oliva M, Litman T, Nakajima S, Li X, Xu H, Workman CT, Scheipers P, Svitacheva N, Labuda T, Krueger JG, Suarez-Farias M, Kabashima K, Guttman-Yassky E
  • Journal Title: J Allergy Clin Immunol Volume: 139 Pages: 562-571
  • DOI: 10.1016/j.jaci.2016.08.029
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased Filaggrin Level May Lead to Sweat Duct Obstruction in Filaggrin Mutant Mice (2017)
  • Author(s): Rerknimitr P, Tanizaki H, Yamamoto Y, Amano W, Nakajima S, Nakashima C, Nonomura Y, Wititsuwannakul J, Miyachi Y, Otsuka A, Kabashima K.
  • Journal Title: Journal of Investigative Dermatology Volume: 137(1) Pages: 248-251
  • DOI: 10.1016/j.jid.2016.07.036
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients (2016)
  • Author(s): Nonomura Y, Otsuka A, Nakashima C, Seidel JA, Kitoh A, Dainichi T, Nakajima S, Sawada Y, Matsushita S, Aoki M, Takenouchi T, Fujimura T, Hatta N, Koreeda S, Fukushima S, Honda T, Kabashima K.
  • Journal Title: OncoImmunology Volume: 5(12)
  • DOI: 10.1080/2162402x.2016.1248327
  • Peer Reviewed
• [Journal Article] Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation (2016)
  • Author(s): Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
  • Journal Title: Immunity Volume: 45(6) Pages: 1299-1310
  • DOI: 10.1016/j.immuni.2016.11.010
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Linking air pollution to atopic dermatitis (2016)
  • Author(s): Kabashima Kenji、Otsuka Atsushi、Nomura Takashi
  • Journal Title: Nature Immunology Volume: 18 Pages: 5-6
  • DOI: 10.1038/ni.3615
  • Peer Reviewed
• [Journal Article] JAK inhibitor JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation (2016)
  • Author(s): Amano Wataru、Nakajima Saeko、Yamamoto Yasuo、Tanimoto Atsuo、Matsushita Mutsuyoshi、Miyachi Yoshiki、Kabashima Kenji
  • Journal Title: Journal of Dermatological Science Volume: 84 Pages: 258-265
  • DOI: 10.1016/j.jdermsci.2016.09.007
  • Peer Reviewed
• [Journal Article] Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation (2016)
  • Author(s): Zhong Franklin L.、Tye Hazel、Roy Keya、Bonnard Carine、Ahl Patricia J.、Jones Leigh Ann、Baker Paul J.、Lacina Lukas、Otsuka Atsushi、Fournie Pierre R.、Malecaze Fran?ois、Lane E. Birgitte、Akiyama Masashi、Kabashima Kenji
  • Journal Title: Cell Volume: 167
  • DOI: 10.1016/j.cell.2016.09.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march (2016)
  • Author(s): Egawa Gyohei、Kabashima Kenji
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 138
  • DOI: 10.1016/j.jaci.2016.06.002
  • Peer Reviewed
• [Journal Article] PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division (2016)
  • Author(s): Dainichi Teruki、Hayden Matthew?S.、Park Sung-Gyoo、Oh Hyunju、Seeley John?J.、Grinberg-Bleyer Yenkel、Beck Kristen?M.、Miyachi Yoshiki、Kabashima Kenji、Hashimoto Takashi、Ghosh Sankar
  • Journal Title: Cell Reports Volume: 15 Pages: 1615-1623
  • DOI: 10.1016/j.celrep.2016.04.051
  • NAID: 120005829374
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Jak1 tyrosine kinase hyperactivation induces stepwise progressive pruritic dermatitis. (2016)
  • Author(s): Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
  • Journal Title: J. Clin. Invest. Volume: 126(6) Pages: 2064-2076
  • DOI: 10.1172/jci82887
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel concept of iSALT (inducible skin-associated lymphoid tissue) in the elicitation of allergic contact dermatitis (2016)
  • Author(s): Honda T, Kabashima K
  • Journal Title: Proc. Jpn. Acad., Ser. B Volume: 92 Issue: 1 Pages: 20-28
  • DOI: 10.2183/pjab.92.20
  • NAID: 130005118554
  • ISSN: 0386-2208
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses (2015)
  • Author(s): Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
  • Journal Title: Journal of Experimental medicine Volume: 212 Pages: 1921-1930
  • DOI: 10.1084/jem.20150381
  • NAID: 120005733188
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia (2015)
  • Author(s): Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M
  • Journal Title: J Exp Med Volume: 212 Pages: 1901-19
  • DOI: 10.1084/jem.20141904
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization (2015)
  • Author(s): Noda S, Suárez-Fariñas M, Ungar B, Kim SJ, de Guzman Strong C, Xu H, Peng X, Estrada YD, Nakajima S, Honda T, Shin JU, Lee H, Krueger JG, Lee KH, Kabashima K, Guttman-Yassky E.
  • Journal Title: J Allergy Clin Immunol Volume: 5 Pages: 1254-1264
  • DOI: 10.1016/j.jaci.2015.08.015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Contribution of Basophils to Cutaneous Immune Reactions and Th2-Mediated Allergic Responses (2015)
  • Author(s): Otsuka A, Kabashima K
  • Journal Title: Front Immunol Volume: 6 Pages: 393-393
  • DOI: 10.3389/fimmu.2015.00393
  • NAID: 120005946999
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling (2015)
  • Author(s): Amano W, Nakajima S, Kunugi H, Numata Y, Kitoh A, Egawa G, Dainichi T, Honda T, Otsuka A, Kimoto Y, Yamamoto Y, Tanimoto A, Matsushita M, Miyachi Y, Kabashima K.
  • Journal Title: J Allergy Clin Immunol Volume: 3 Pages: 667-677
  • DOI: 10.1016/j.jaci.2015.03.051
  • NAID: 40020962725
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Cutaneous immune responses to foreign antigen exposure (2018)
  • Author(s): Kenji Kabashima
  • Organizer: EAACI in Munich
  • Int'l Joint Research / Invited
• [Presentation] 外的刺激に対する皮膚の生体応答 (2018)
  • Author(s): 椛島健治
  • Organizer: 日本細胞生物学会
  • Invited
• [Presentation] Skin immune responses to external stimuli (2018)
  • Author(s): Kenji Kabashima
  • Organizer: International Symposium Frontiers in Skin Immunity
  • Int'l Joint Research / Invited
• [Presentation] 神経と皮膚免疫の相互作用 サイトカインの観点から (2018)
  • Author(s): 椛島健治
  • Organizer: 第83回 日本サイトカインインターフェロン学会
  • Invited
• [Presentation] Visualization of skin inflammation and resulting immunologic concepts (2018)
  • Author(s): Kenji Kabashima
  • Organizer: ISDS 2018
  • Int'l Joint Research / Invited
• [Presentation] Novel pathogenesis of atopic dermatitis (2017)
  • Author(s): Kenji Kabashima
  • Organizer: The 17th Edition of Dubai World Dermatology and Laser Conference Dubai Derma 2017
  • Int'l Joint Research / Invited
• [Presentation] 乾癬の発症機序と治療のupdate (2017)
  • Author(s): 椛島健治
  • Organizer: 日本リウマチ学会
  • Invited
• [Presentation] Cutaneous biological responses to external stimuli (2017)
  • Author(s): Kenji Kabashima
  • Organizer: 8TH PAN-PACIFIC SKIN BARRIER SYMPOSIUM Portland Oregon
  • Int'l Joint Research / Invited
• [Presentation] Live imaging of the skin immune responses (2017)
  • Author(s): Kenji Kabashima
  • Organizer: The 12th Uehara International Symposium ”Make Life Visible"
  • Int'l Joint Research / Invited
• [Presentation] アトピー性皮膚炎の新しい治療(の可能性） (2017)
  • Author(s): 椛島健治
  • Organizer: 日本皮膚科学会 市民公開講座 「正しく知ろうアトピー」
  • Invited
• [Presentation] Live imaging of skin immune responses (2017)
  • Author(s): Kenji Kabashima
  • Organizer: 26th EADV Congress in Geneva, Switzerland
  • Int'l Joint Research / Invited
• [Presentation] 免疫反応の可視化 (2016)
  • Author(s): 椛島健治
  • Organizer: 第60回 日本リウマチ学会総会・学術集会
  • Invited
• [Presentation] Recent advances in the pathogenesis and treatment of atopic dermatitis (2016)
  • Author(s): Kenji Kabashima
  • Organizer: International Eczema Council at the SID meeting
  • Invited
• [Presentation] Cutaneous immune responses to external antigen (2016)
  • Author(s): Kenji Kabashima
  • Organizer: AAI meeting in Seattle
  • Invited
• [Presentation] Live imaging of skin immune responses (2016)
  • Author(s): Kenji Kabashima
  • Organizer: IgE and Allergy: 50 Years and Onward FASEB Meeting , West Perm Beach, Florida, USA
  • Invited
• [Presentation] Live imaging of skin immune responses (2016)
  • Author(s): Kenji Kabashima
  • Organizer: ADC 2016 Mumbai, India
  • Invited
• [Presentation] Skin inflammation by 3-dimensional imaging (2016)
  • Author(s): Kenji Kabashima
  • Organizer: The 2nd ISDS NYC in USA
  • Invited
• [Presentation] ライブイメージングにより明らかにされた接触皮膚炎の発症機序 (2015)
  • Author(s): Kenji Kabashima
  • Organizer: 第114回 日本皮膚科学会総会,
  • Place of Presentation: 横浜
• [Presentation] Multiphoton Skin Imaging (2015)
  • Author(s): Kenji Kabashima
  • Organizer: 23th World Congress of Dermatology
  • Place of Presentation: Vancouver
  • Int'l Joint Research
• [Presentation] Perivascular leukocyte clusters (inducible skin-associated lymphoid tissue; iSALT) are essential for efficient effector T cell activation in the skin (2015)
  • Author(s): Kenji Kabashima
  • Organizer: FIMSA
  • Place of Presentation: Singapore
  • Int'l Joint Research
• [Presentation] Identification of inducible skin-assocaited lymphoid tissue (iSALT) in the skin (2015)
  • Author(s): Kenji Kabashima
  • Organizer: 14th International Workshop on Langerhans Cells
  • Place of Presentation: kyoto,Japan
  • Int'l Joint Research