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Understanding the mechanism how the skin responses to external stimuli

Research Project

Project/Area Number 15H05790
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKyoto University

Principal Investigator

Kabashima Kenji  京都大学, 医学研究科, 教授 (00362484)

Co-Investigator(Kenkyū-buntansha) 大日 輝記  香川大学, 医学部, 教授 (20423543)
國澤 純  国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, センター長 (80376615)
Project Period (FY) 2015-05-29 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥191,100,000 (Direct Cost: ¥147,000,000、Indirect Cost: ¥44,100,000)
Fiscal Year 2019: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2018: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2017: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2016: ¥60,190,000 (Direct Cost: ¥46,300,000、Indirect Cost: ¥13,890,000)
Fiscal Year 2015: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Keywords皮膚科学 / 免疫学 / アレルギー学 / 皮膚 / 免疫 / アレルギー / アレルギー・ぜんそく / 生体イメージング / 皮膚免疫
Outline of Final Research Achievements

In this study, the system which comprehensively visualized constituent cells and structures of the skin was newly constructed, and the tool which enabled the analysis of cell function which constitutes the skin was developed. Using this tool, we found that lymphotoxin acts on vascular endothelial cells to induce high endothelial venules and plays an important role in the maintenance of iSALT architecture and functional control. Focusing on the post-capillary venules, we identified a kinase pathway that is key to the active transport of antibodies from blood to the skin by vascular endothelial cells in the post-capillary venule region. We have been engaged in the elucidation of the mechanism which induced the pruritus by the external stimulation. We sought to control pruritus by targeting IL -31 receptor. Taken together, we have clarified the mechanism of iSALT formation through the interaction of epithelial cells, immune cells, nerve cells and interstitial cells.

Academic Significance and Societal Importance of the Research Achievements

皮膚を含めた末梢臓器において様々な免疫・アレルギー疾患が誘導されるが、免疫応答は、リンパ節や骨髄、胸腺のようなリンパ器官のみならず、末梢臓器においても精密な調節機構が存在していることが想定される。したがって、iSALTの誘導機序やその意義の解明を軸に、外的刺激に対する皮膚の免疫応答の多様性の誘導機構を解明することの学術的意義は大きく、また、皮膚を超えた他臓器の免疫応答の理解にも繋がりうる。また、本研究成果は、アトピー性皮膚炎や尋常性乾癬の理解のみならず、治療への応用の展開の可能性も有するため、その社会的意義は大きい。

Assessment Rating
Verification Result (Rating)

A+

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2021 Research Progress Assessment (Verification Result) ( PDF )
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (70 results)

All 2021 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (35 results) (of which Int'l Joint Research: 24 results,  Peer Reviewed: 35 results,  Open Access: 10 results,  Acknowledgement Compliant: 9 results) Presentation (26 results) (of which Int'l Joint Research: 15 results,  Invited: 22 results) Book (3 results)

  • [Int'l Joint Research] A*Star(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Mount Sinai University/UCSF/Oregon Health Science Hospital(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] King's College London(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Amsterdam University(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Ottawa(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Journal Article] PD-L1 on mast cells suppresses effector CD8+ T-cell activation in the skin in murine contact hypersensitivity2021

    • Author(s)
      Hirano Tomoko、Honda Tetsuya、Kanameishi Shuto、Honda Yuki、Egawa Gyohei、Kitoh Akihiko、Nakajima Saeko、Otsuka Atsushi、Nomura Takashi、Dainichi Teruki、Yaguchi Tomonori、Inozume Takashi、Kataoka Tatsuki R.、Tamada Koji、Kabashima Kenji
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: in press Issue: 2 Pages: 00178-00178

    • DOI

      10.1016/j.jaci.2020.12.654

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes cutaneous dendritic cell functions in contact hypersensitivity.2021

    • Author(s)
      Yasuo Yamamoto 1, Atsushi Otsuka 2, Yoshihiro Ishida 3, Lai San Wong 4, Judith A Seidel 3, Yumi Nonomura 3, Chisa Nakashima 3, Saeko Nakajima 3, Akihiko Kitoh 3, Takashi Nomura 3, Teruki Dainichi 3, Tetsuya Honda 3, Wataru Amano 1, Noriko Konishi 5, Mikio Hayashi 5, Mutsuyoshi Matsushita 5, Kenji Kabashima 6
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 18;S0091-6749(21) Issue: 3 Pages: 00218-9

    • DOI

      10.1016/j.jaci.2021.02.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus2020

    • Author(s)
      Kabashima K, Matsumura T, Komazaki H, Kawashima M; Nemolizumab-JP01 Study Group.
    • Journal Title

      N Engl J Med.

      Volume: 383 Issue: 2 Pages: 141-150

    • DOI

      10.1056/nejmoa1917006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.2019

    • Author(s)
      Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 144(4) Issue: 4 Pages: 1036-1049

    • DOI

      10.1016/j.jaci.2019.06.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model2019

    • Author(s)
      Ono S, Egawa G, Nomura T, Kitoh A, Dainichi T, Otsuka A, Nakajima S, Amagai M, Matsumoto F, Yamamoto M, Kubota Y, Takai T, Honda T, Kabashima K.
    • Journal Title

      Nat Commun

      Volume: 10(1) Issue: 1 Pages: 4432-4432

    • DOI

      10.1038/s41467-019-12232-3

    • NAID

      120006731596

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches.2019

    • Author(s)
      Chakarov S, Lim HY, Tan L, Lim SY, See P, Lum J, Zhang XM, Foo S, Nakamizo S, Duan K, Kong WT, Gentek R, Balachander A, Carbajo D, Bleriot C, Malleret B, Tam JKC, Baig S, Shabeer M, Toh SES, Schlitzer A, Larbi A, Marichal T, Malissen B, Chen J, Poidinger M, Kabashima K, Bajenoff M, Ng LG, Angeli V, Ginhoux F.
    • Journal Title

      Science.

      Volume: 15 Issue: 6432

    • DOI

      10.1126/science.aau0964

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antigen presentation and adaptive immune responses in skin.2019

    • Author(s)
      Honda T, Egawa G, Kabashima K.
    • Journal Title

      Int Immunol.

      Volume: 0 Issue: 7 Pages: 0-0

    • DOI

      10.1093/intimm/dxz005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Insights into atopic dermatitis gained from genetically defined mouse models.2019

    • Author(s)
      Nakajima S, Nomura T, Common J, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 143(1) Pages: 13-25

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The immunological anatomy of the skin2018

    • Author(s)
      Kabashima Kenji、Honda Tetsuya、Ginhoux Florent、Egawa Gyohei
    • Journal Title

      Nature Reviews Immunology

      Volume: 19 Issue: 1 Pages: 19-30

    • DOI

      10.1038/s41577-018-0084-5

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis2018

    • Author(s)
      Dainichi Teruki、Kitoh Akihiko、Otsuka Atsushi、Nakajima Saeko、Nomura Takashi、Kaplan Daniel H.、Kabashima Kenji
    • Journal Title

      Nature Immunology

      Volume: 19 Issue: 12 Pages: 1286-1298

    • DOI

      10.1038/s41590-018-0256-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.2018

    • Author(s)
      Matsumoto R, Dainichi T, Tsuchiya S, Nomura T, Kitoh A, Hayden MS, Ishii KJ, Tanaka M, Honda T, Egawa G, Otsuka A, Nakajima S, Sakurai K, Nakano Y, Kobayashi T, Sugimoto Y, Kabashima K.
    • Journal Title

      JCI Insight.

      Volume: 9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study.2018

    • Author(s)
      Kabashima K, Furue M, Hanifin JM, Pulka G, Wollenberg A, Galus R, Etoh T, Mihara R, Nakano M, Ruzicka T.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 142(4) Issue: 4 Pages: 1121-1130.e7

    • DOI

      10.1016/j.jaci.2018.03.018

    • NAID

      120006601464

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model2018

    • Author(s)
      Sachiko Ono, Gyohei Egawa, Tetsuya Honda, and Kenji Kabashima
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 印刷中 Issue: 6 Pages: 2273-2276.e1

    • DOI

      10.1016/j.jaci.2017.12.985

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of IL-17 committed T cells in a murine psoriasis model by a vitamin D analogue2018

    • Author(s)
      Kusuba Nobuhiro、Kitoh Akihiko、Dainichi Teruki、Honda Tetsuya、Otsuka Atsushi、Egawa Gyohei、Nakajima Saeko、Miyachi Yoshiki、Kabashima Kenji
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 141 Issue: 3 Pages: 972-981.e10

    • DOI

      10.1016/j.jaci.2017.07.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RIPK3 controls keratinocyte activation in a necroptosis-independent manner and promotes psoriatic dermatitis in mice2017

    • Author(s)
      Tetsuya Honda, Osamu Yamamoto MD, Yu Sawada, Gyohei Egawa, Akihiko Kitoh, Atsushi Otsuka, Teruki Dainichi, Saeko Nakajima, Yoshiki Miyachi, Kenji Kabashima
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 5 Issue: 2 Pages: 619-622.e6

    • DOI

      10.1016/j.jaci.2017.02.027

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis.2017

    • Author(s)
      Ruzicka T, Hanifin JM, Furue M, Pulka G, Mlynarczyk I, Wollenberg A, Galus R, Etoh T, Mihara R, Yoshida H, Stewart J, Kabashima K; XCIMA Study Group.
    • Journal Title

      N Engl J Med.

      Volume: 2;376(9) Issue: 9 Pages: 826-835

    • DOI

      10.1056/nejmoa1606490

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Local inflammation exacerbates cutaneous manifestations in a murine autoimmune pemphigus model2017

    • Author(s)
      S. Ono, G. Egawa, A. Kitoh, T. Dainichi, A. Otsuka, S. Nakajima, T, Honda, K. Kabashima
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 印刷中 Issue: 6 Pages: 2026-2028.e5

    • DOI

      10.1016/j.jaci.2016.12.959

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma.2017

    • Author(s)
      Honda Y, Otsuka A, Ono S, Yamamoto Y, Seidel JA, Morita S, Hirata M, Kataoka TR, Takenouchi T, Fujii K, Kanekura T, Okubo Y, Takahashi K, Yanagi T, Hoshina D, Hata H, Abe R, Fujimura T, Funakoshi T, Yoshino K, Masuzawa M, Amoh Y, Tanaka R, Fujisawa Y, Honda T, Kabashima K.
    • Journal Title

      Oncoimmunology.

      Volume: 6 Issue: 1 Pages: e1253657-e1253657

    • DOI

      10.1080/2162402x.2016.1253657

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increasing Comorbidities Suggest that Atopic Dermatitis?Is?a?Systemic Disorder2017

    • Author(s)
      Brunner Patrick M.、Silverberg Jonathan I.、Guttman-Yassky Emma、Paller Amy S.、Kabashima Kenji、Amagai Masayuki、Luger Thomas A.、Deleuran Mette、Werfel Thomas、Eyerich Kilian、Stingl Georg、Bagot Martine、Hijnen Dirk Jan、Ardern-Jones Michael、Reynolds Nick、Spuls Phyllis、Taieb Alain
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 137 Issue: 1 Pages: 18-25

    • DOI

      10.1016/j.jid.2016.08.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling2017

    • Author(s)
      Ewald DA, Noda S, Oliva M, Litman T, Nakajima S, Li X, Xu H, Workman CT, Scheipers P, Svitacheva N, Labuda T, Krueger JG, Suarez-Farias M, Kabashima K, Guttman-Yassky E
    • Journal Title

      J Allergy Clin Immunol

      Volume: 139 Issue: 2 Pages: 562-572

    • DOI

      10.1016/j.jaci.2016.08.029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decreased Filaggrin Level May Lead to Sweat Duct Obstruction in Filaggrin Mutant Mice.2017

    • Author(s)
      Rerknimitr P, Tanizaki H, Yamamoto Y, Amano W, Nakajima S, Nakashima C, Nonomura Y, Wititsuwannakul J, Miyachi Y, Otsuka A, Kabashima K.
    • Journal Title

      J Invest Dermatol

      Volume: 137(1) Issue: 1 Pages: 248-251

    • DOI

      10.1016/j.jid.2016.07.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients.2016

    • Author(s)
      Nonomura Y, Otsuka A, Nakashima C, Seidel JA, Kitoh A, Dainichi T, Nakajima S, Sawada Y, Matsushita S, Aoki M, Takenouchi T, Fujimura T, Hatta N, Koreeda S, Fukushima S, Honda T, Kabashima K.
    • Journal Title

      Oncoimmunology

      Volume: 5(12) Issue: 12 Pages: e1248327-e1248327

    • DOI

      10.1080/2162402x.2016.1248327

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.2016

    • Author(s)
      Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
    • Journal Title

      Immunity.

      Volume: 45(6) Issue: 6 Pages: 1299-1310

    • DOI

      10.1016/j.immuni.2016.11.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Linking air pollution to atopic dermatitis2016

    • Author(s)
      Kabashima Kenji、Otsuka Atsushi、Nomura Takashi
    • Journal Title

      Nature Immunology

      Volume: 18 Issue: 1 Pages: 5-6

    • DOI

      10.1038/ni.3615

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JAK inhibitor JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation2016

    • Author(s)
      Amano Wataru、Nakajima Saeko、Yamamoto Yasuo、Tanimoto Atsuo、Matsushita Mutsuyoshi、Miyachi Yoshiki、Kabashima Kenji
    • Journal Title

      Journal of Dermatological Science

      Volume: 84 Issue: 3 Pages: 258-265

    • DOI

      10.1016/j.jdermsci.2016.09.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation2016

    • Author(s)
      Zhong Franklin L.、Tye Hazel、Roy Keya、Bonnard Carine、Ahl Patricia J.、Jones Leigh Ann、Baker Paul J.、Lacina Lukas、Otsuka Atsushi、Fournie Pierre R.、Malecaze Fran?ois、Lane E. Birgitte、Akiyama Masashi、Kabashima Kenji
    • Journal Title

      Cell

      Volume: 167 Issue: 1 Pages: 187-202.e17

    • DOI

      10.1016/j.cell.2016.09.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march2016

    • Author(s)
      Egawa Gyohei、Kabashima Kenji
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 138 Issue: 2 Pages: 350-358.e1

    • DOI

      10.1016/j.jaci.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division2016

    • Author(s)
      Dainichi Teruki、Hayden Matthew?S.、Park Sung-Gyoo、Oh Hyunju、Seeley John?J.、Grinberg-Bleyer Yenkel、Beck Kristen?M.、Miyachi Yoshiki、Kabashima Kenji、Hashimoto Takashi、Ghosh Sankar
    • Journal Title

      Cell Reports

      Volume: 15 Issue: 8 Pages: 1615-1623

    • DOI

      10.1016/j.celrep.2016.04.051

    • NAID

      120005829374

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis2016

    • Author(s)
      Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
    • Journal Title

      J. Clin. Invest

      Volume: 126(6) Issue: 6 Pages: 2064-76

    • DOI

      10.1172/jci82887

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Novel concept of iSALT (inducible skin-associated lymphoid tissue) in the elicitation of allergic contact dermatitis2016

    • Author(s)
      Honda T, Kabashima K
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 92 Issue: 1 Pages: 20-28

    • DOI

      10.2183/pjab.92.20

    • NAID

      130005118554

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.2015

    • Author(s)
      Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
    • Journal Title

      J Exp Med

      Volume: 212 Issue: 11 Pages: 1921-1930

    • DOI

      10.1084/jem.20150381

    • NAID

      120005733188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of group IIF secreted phospholipase A2 in epidermal homeostasis and hyperplasia.2015

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M
    • Journal Title

      J. Exp. Med.

      Volume: 212 Issue: 11 Pages: 1901-1919

    • DOI

      10.1084/jem.20141904

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization.2015

    • Author(s)
      Noda S, Suárez-Fariñas M, Ungar B, Kim SJ, de Guzman Strong C, Xu H, Peng X, Estrada YD, Nakajima S, Honda T, Shin JU, Lee H, Krueger JG, Lee KH, Kabashima K, Guttman-Yassky E.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 5 Issue: 5 Pages: 1254-1264

    • DOI

      10.1016/j.jaci.2015.08.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Contribution of Basophils to Cutaneous Immune Reactions and Th2-Mediated Allergic Responses2015

    • Author(s)
      Otsuka A, Kabashima K
    • Journal Title

      Front Immunol

      Volume: 6 Pages: 393-393

    • DOI

      10.3389/fimmu.2015.00393

    • NAID

      120005946999

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling.2015

    • Author(s)
      Amano W, Nakajima S, Kunugi H, Numata Y, Kitoh A, Egawa G, Dainichi T, Honda T, Otsuka A, Kimoto Y, Yamamoto Y, Tanimoto A, Matsushita M, Miyachi Y, Kabashima K.
    • Journal Title

      10.1016/j.jaci.2015.03.051.

      Volume: 3 Issue: 3 Pages: 667-677

    • DOI

      10.1016/j.jaci.2015.03.051

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection.2020

    • Author(s)
      Kenji Kabashima
    • Organizer
      World Immune Regulation Meeting XIV 04-07
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Atopic Dermatitis2020

    • Author(s)
      Kenji Kabashima
    • Organizer
      Precision Medicine JSA/WAO Joint Congress in 2020.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of Th2 cytokines in cutaneous immune responses2019

    • Author(s)
      Kenjki Kabashima
    • Organizer
      Cytokines 2019 International Cytokine and Interferon Society (ICIS) Vienna, Austria.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel roles of skin dendritic cells in skin immune responses2019

    • Author(s)
      Kenji Kabashima
    • Organizer
      International Langerhans cell workshop 2019 Mainz, Germany.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IgE passes through placenta but hardly sensitize dermal mast cells in mouse.2019

    • Author(s)
      Kenji Kabashima
    • Organizer
      FASEB meeting The IgE and Allergy Conference Scottsdale, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cutaneous immune responses to foreign antigen exposure2018

    • Author(s)
      Kenji Kabashima
    • Organizer
      EAACI in Munich
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 外的刺激に対する皮膚の生体応答2018

    • Author(s)
      椛島健治
    • Organizer
      日本細胞生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Skin immune responses to external stimuli2018

    • Author(s)
      Kenji Kabashima
    • Organizer
      International Symposium  Frontiers in Skin Immunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経と皮膚免疫の相互作用 サイトカインの観点から2018

    • Author(s)
      椛島健治
    • Organizer
      第83回 日本サイトカインインターフェロン学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Visualization of skin inflammation and resulting immunologic concepts2018

    • Author(s)
      Kenji Kabashima
    • Organizer
      ISDS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel pathogenesis of atopic dermatitis2017

    • Author(s)
      Kenji Kabashima
    • Organizer
      The 17th Edition of Dubai World Dermatology and Laser Conference Dubai Derma 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 乾癬の発症機序と治療のupdate2017

    • Author(s)
      椛島健治
    • Organizer
      日本リウマチ学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Cutaneous biological responses to external stimuli2017

    • Author(s)
      Kenji Kabashima
    • Organizer
      8TH PAN-PACIFIC SKIN BARRIER SYMPOSIUM Portland Oregon
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Live imaging of the skin immune responses2017

    • Author(s)
      Kenji Kabashima
    • Organizer
      The 12th Uehara International Symposium ”Make Life Visible"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アトピー性皮膚炎の新しい治療(の可能性)2017

    • Author(s)
      椛島健治
    • Organizer
      日本皮膚科学会 市民公開講座 「正しく知ろうアトピー」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Live imaging of skin immune responses2017

    • Author(s)
      Kenji Kabashima
    • Organizer
      26th EADV Congress in Geneva, Switzerland
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 免疫反応の可視化2016

    • Author(s)
      椛島健治
    • Organizer
      第60回 日本リウマチ学会総会・学術集会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Recent advances in the pathogenesis and treatment of atopic dermatitis2016

    • Author(s)
      Kenji Kabashima
    • Organizer
      International Eczema Council at the SID meeting
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cutaneous immune responses to external antigen2016

    • Author(s)
      Kenji Kabashima
    • Organizer
      AAI meeting in Seattle
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Live imaging of skin immune responses2016

    • Author(s)
      Kenji Kabashima
    • Organizer
      IgE and Allergy: 50 Years and Onward FASEB Meeting , West Perm Beach, Florida, USA
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Live imaging of skin immune responses2016

    • Author(s)
      Kenji Kabashima
    • Organizer
      ADC 2016 Mumbai, India
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Skin inflammation by 3-dimensional imaging2016

    • Author(s)
      Kenji Kabashima
    • Organizer
      The 2nd ISDS NYC in USA
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ライブイメージングにより明らかにされた接触皮膚炎の発症機序2015

    • Author(s)
      Kenji Kabashima
    • Organizer
      第114回 日本皮膚科学会総会,
    • Place of Presentation
      横浜
    • Related Report
      2015 Annual Research Report
  • [Presentation] Multiphoton Skin Imaging2015

    • Author(s)
      Kenji Kabashima
    • Organizer
      23th World Congress of Dermatology
    • Place of Presentation
      Vancouver
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Perivascular leukocyte clusters (inducible skin-associated lymphoid tissue; iSALT) are essential for efficient effector T cell activation in the skin2015

    • Author(s)
      Kenji Kabashima
    • Organizer
      FIMSA
    • Place of Presentation
      Singapore
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of inducible skin-assocaited lymphoid tissue (iSALT) in the skin2015

    • Author(s)
      Kenji Kabashima
    • Organizer
      14th International Workshop on Langerhans Cells
    • Place of Presentation
      kyoto,Japan
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 実験医学 2083-2088 【線維化 慢性疾患のキープロセス 多彩な間質細胞が織りなす組織リモデリング"fibrosis"の理解】(第3章)各臓器疾患における線維化 全身性強皮症における皮膚線維化(解説/特集)2020

    • Author(s)
      鬼頭昭彦、椛島健治
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report
  • [Book] 実験医学 1084-1091  【臓器連環による生体恒常性の破綻と疾患 すべての医学者・生命科学者に捧ぐ】(第2章)組織・臓器、個体における動的恒常性とその破綻 組織・臓器における動的恒常性とその破綻 皮膚の生体防御の動的恒常性とその破綻(解説/特集)2019

    • Author(s)
      大日輝記、椛島健治
    • Total Pages
      8
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report
  • [Book] 実験医学 2320-2325 【疾患を制御するマクロファージの多様性】皮膚とマクロファージ(解説/特集)2019

    • Author(s)
      中溝聡、江川形平、椛島健治
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report

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Published: 2015-06-03   Modified: 2023-10-16  

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