| Budget Amount *help |
¥191,100,000 (Direct Cost: ¥147,000,000、Indirect Cost: ¥44,100,000)
Fiscal Year 2019: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2018: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2017: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2016: ¥60,190,000 (Direct Cost: ¥46,300,000、Indirect Cost: ¥13,890,000)
Fiscal Year 2015: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
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| Outline of Final Research Achievements |
In this study, the system which comprehensively visualized constituent cells and structures of the skin was newly constructed, and the tool which enabled the analysis of cell function which constitutes the skin was developed. Using this tool, we found that lymphotoxin acts on vascular endothelial cells to induce high endothelial venules and plays an important role in the maintenance of iSALT architecture and functional control. Focusing on the post-capillary venules, we identified a kinase pathway that is key to the active transport of antibodies from blood to the skin by vascular endothelial cells in the post-capillary venule region. We have been engaged in the elucidation of the mechanism which induced the pruritus by the external stimulation. We sought to control pruritus by targeting IL -31 receptor. Taken together, we have clarified the mechanism of iSALT formation through the interaction of epithelial cells, immune cells, nerve cells and interstitial cells.
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