| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Transformed cells surrounded by normal cells are eliminated from epithelium. Since the elimination does not occur under the condition of single culture, there should be some cross-talk signals between normal and transformed cells. From microarray analyses, we identified several genes that is up-regulated inside of normal cells. Prostaglandins were the downstream of a gene identified in the microarray analyses. Furthermore, a prostaglandin attenuated the elimination efficiency of transformed cells, indicating that signals from normal cells are also important to regulate the elimination of transformed cells.
|
