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Identification of genes related to signals from transformed cells

Research Project

Project/Area Number 15H05990
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionHokkaido University

Principal Investigator

Maruyama Takeshi  北海道大学, 遺伝子病制御研究所, 助教 (30613872)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords哺乳類細胞競合 / 細胞死 / がん / 細胞競合
Outline of Final Research Achievements

Transformed cells surrounded by normal cells are eliminated from epithelium. Since the elimination does not occur under the condition of single culture, there should be some cross-talk signals between normal and transformed cells. From microarray analyses, we identified several genes that is up-regulated inside of normal cells. Prostaglandins were the downstream of a gene identified in the microarray analyses. Furthermore, a prostaglandin attenuated the elimination efficiency of transformed cells, indicating that signals from normal cells are also important to regulate the elimination of transformed cells.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells2017

    • Author(s)
      Maruyama T, Saitoh S, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M and Fujita Y
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 114 Issue: 12 Pages: 3157-3162

    • DOI

      10.1073/pnas.1701746114

    • NAID

      120006346108

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant

URL: 

Published: 2015-08-26   Modified: 2018-03-22  

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