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Role of VTA-PFC circuit in an animal model of anxiety disorders

Research Project

Project/Area Number 15H05995
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pharmacology in pharmacy
Research InstitutionHokkaido University

Principal Investigator

HITORA Natsuko  北海道大学, 薬学研究院, 助教 (40762191)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経科学 / 記憶・学習 / 不安障害 / 神経回路 / 脳・神経 / 行動薬理学 / 再発 / ドパミン
Outline of Final Research Achievements

We investigated neural basis of fear reinstatement, which was used as an animal model of relapse of anxiety disorders. We found that prefrontal dopamine D1 receptor, but not D2 receptor, is necessary for fear reinstatement. Also, we did anatomical analysis on prefrontal neuronal circuits and found that there is a dense projection from prefrontal cortex (PFC) to periaqueductal gray matter (PAG). Optogenetic activation of PFC-PAG increased locomotor activity. These results contribute to elucidate the mechanism by which animals flexibly regulate behavior according to the environment.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2016

All Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Prevention of fear re-appearance by blockage of dopamine signaling2016

    • Author(s)
      Natsuko Hitora-Imamura, Yuki Miura, Chie Teshirogi, Yuji Ikegaya, Norio Matsuki, Hiroshi Nomura
    • Organizer
      The 46th Annual Meeting of The Society for Neuroscience
    • Place of Presentation
      San Diego (アメリカ)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevention of fear re-appearance by blockage of dopamine signaling2016

    • Author(s)
      Natsuko Hitora-Imamura, Yuki Miura, Chie Teshirogi, Yuji Ikegaya, Norio Matsuki, Hiroshi Nomura
    • Organizer
      The 15th Annual Molecular and Cellular Cognition Society Meeting
    • Place of Presentation
      San Diego (アメリカ)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prefrontal dopamine-dependent plasticity mediates relapse in an animal model of anxiety disorders2016

    • Author(s)
      Natsuko Hitora-Imamura, Yuki Miura, Chie Teshirogi, Yuji Ikegaya, Norio Matsuki, Hiroshi Nomura
    • Organizer
      The 30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      ソウル (韓国)
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 不安障害再発モデルにおける前頭前皮質ドパミンの機能解明2016

    • Author(s)
      人羅(今村)菜津子、三浦友樹、手代木知恵、池谷裕二、松木則夫、野村洋
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      ソウル (韓国)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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