Molecular mechanisms that regulates the localization of organelles
| Project/Area Number |
15H06033
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
Niwa Shinsuke 東北大学, 学際科学フロンティア研究所, 助教 (30714985)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 細胞生物学 / 神経科学 / 軸索輸送 / キネシン / IFT / 細胞・組織 / 細胞骨格 |
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| Outline of Final Research Achievements |
I have started to analyze molecular mechanisms that regulate the localization of organelles in neurons. I have obtained following results: (1) I have cloned a new gene called ift-139 that is required for the intraflagellar transport (IFT) (Niwa et al. Scientific reports, 2016) (2) I hace clarified a molecular mechanism of the autoinhibition of the axonal transport motor, UNC-104/KIF1A (Niwa et al., Cell Reports, 2016)
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Report
(3 results)
Research Products
(10 results)
