| Project/Area Number |
15H06056
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Akita University |
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Principal Investigator |
Morii Mayako 秋田大学, 医学部, 助教 (10375280)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 短腸症候群 / ω-3系脂肪酸 / 腸管機能不全合併肝障害 / 肝線維化 / 脂肪肝 / 星細胞 / 短調症候群 / ω3系脂肪酸 / 肝障害 / ω３系脂肪酸 / 肝臓星細胞 |
|---|
| Outline of Final Research Achievements |
We performed the lipidmics of two patients successfully treated with the fish oil lipid emulsion (FOLE) to clarify the effective component in the FOLE. The liver biopsy was performed every year, and fibrosis with fatty degeneration was getting worse trough several years. The periportal inflammation and fibrosis with bile ductular proliferation was obvious just before the supplemental FOLE. After the introduction of FOLE (0.5~1 g/kg/day), replacing the same amount of soybean oil emulsion (SOLE), inflammatory cell infiltration was disappeared and furthermore there was a improvement of the hepatic fibrosis. Lipid extraction and measurement of lipid metabolites by LC-MS/MS was performed in the patients and six healthy volunteers. according to the lipidmics, it was revealed that the n－3 fatty acid and metabolites of the patients were approximately 10-times greater than those of healthy volunteers.
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